Antibacterial Activity of Lysimachia nummularia L. in Oro-Dental Diseases

The aim is to evaluate the antibacterial and antifungal properties of the extracts obtained from Lysimachia nummularia L. in order to be able to introduce these extracts into pharmaceutical products and obtain useful products in the infectious and antifungal pathology of the oro-dental cavity. Extracts from different parts of the studied species have been obtained and chemically characterized: the total polyphenols in 40% ethanolic extracts have been determined and the caffeic and chlorogenic acids and trans-resveratrol, bioactive compounds involved in the antimicrobial properties of the studied species, have been identified, separated, and quantitatively determined. The antibacterial and antifungal activities of the extract of Lisymachia nummularia L. were determined using the diffusion method against a set of bacteria isolated from samples from different patients with diseases of the oro-dental cavity. The extract of Lisymachia nummularia L. exhibited antimicrobial activity against Gram-positive bacteria more than Gram-negative, where the effect was weaker; however, it had no antifungal effects on Candida albicans. Another aspect that must be emphasized is that the best antibacterial results were obtained from the aerial segment of the plant, the part where the highest concentration of polyphenols was identified in the studies presented. These results indicate that the pharmacological effects of the studied bacterial species support the use of extracts in obtaining pharmaceutical products that can be used to optimize treatment schemes in oro-dental diseases.

Automated summary

The aim of this study was to evaluate the antibacterial and antifungal properties of extracts from Lysimachia nummularia L. for pharmaceutical product development in the treatment of infectious and antifungal oral diseases. Different extracts from the plant were obtained and chemically characterized. The extracts exhibited antimicrobial activity against Gram-positive bacteria, but had weaker effects on Gram-negative bacteria and no antifungal effects on Candida albicans. The aerial parts of the plant had the highest concentration of polyphenols and showed the best antibacterial results.