期刊
APPLIED SCIENCES-BASEL
卷 13, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/app13116616
关键词
multicomponent reaction; Mannich reaction; 1-amidoalkyl-2-naphthol; bioactivity; aminoalkyl naphthol; oxazine
Currently, there is growing interest in 1-amidoalkyl-2-naphthol derivatives due to their biological activities and potential use in the synthesis of other important bioactive molecules. One-pot multicomponent Mannich reactions are commonly employed for the synthesis of the 1-amidoalkyl-2-naphthol moiety. This review summarizes recent advances in the preparation of 1-amidoalkyl-2-naphthols using different catalysts and provides an overview of published data from the past 3 years. It also highlights the structure, synthetic transformation, and biological importance of this class of products.
Currently, 1-amidoalkyl-2-naphthol derivatives are of increasing interest due to their biological activities and further use in the preparation of other important bioactive molecules, such as aminoalkyl naphthols and oxazines. The synthesis of 1-amidoalkyl-2-naphthol moiety is usually achieved by employing one-pot multicomponent Mannich reactions. This review covers the recent reports on 1-amidoalkyl-2-naphthols' preparation with the use of different catalysts and summarizes the available published data for the period of the last 3 years. It also puts emphasis on the structure, synthetic transformation and biological importance of this class of products.
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