4.8 Article

Modulation of Autophagy Direction to Enhance Antitumor Effect of Endoplasmic-Reticulum-Targeted Therapy: Left or Right?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Redirecting Chemotherapeutics to the Endoplasmic Reticulum Increases Tumor Immunogenicity and Potentiates Anti-PD-L1 Therapy

Yucheng Xiang et al.

Summary: ER-targeted delivery of doxorubicin (DOX) attenuates its original cytotoxic effect while increasing the ability to induce immunogenic cell death; High ER-targeting efficiency correlates with greater ER stress, leading to a shift in the mode of action of DOX from nuclear DNA damage to ER stress-mediated effects; Combining naive and ER-targeted DOX for in vivo application results in tumor regression through a dual mechanism of direct killing and ICD-associated immunity, enhanced by simultaneous inhibition of adaptive PD-L1 enrichment.
Article Chemistry, Multidisciplinary

Split bullets loaded nanoparticles for amplified immunotherapy

Chendong Liu et al.

Summary: A split bullets loaded nanoplatform is developed to enhance the function of dendritic cells (DCs) in adaptive antitumor immunity by bidirectionally damaging the mitochondria and endoplasmic reticulum of tumor cells.

JOURNAL OF CONTROLLED RELEASE (2022)

Review Pharmacology & Pharmacy

Nanodrugs Manipulating Endoplasmic Reticulum Stress for Highly Effective Antitumor Therapy

Yuting Xiang et al.

Summary: This article summarizes the latest developments in using nanodrugs to manipulate ER stress for cancer treatment. The prospects of nanodrugs enhancing ER stress for cancer treatment are discussed, providing insights for novel therapeutic approaches and the design of nanodrugs.

FRONTIERS IN PHARMACOLOGY (2022)

Review Cell Biology

The pleiotropic functions of autophagy in metastasis

Timothy Marsh et al.

Summary: Autophagy plays complex roles in cancer metastasis, affecting therapeutic approaches. It can both promote tumor growth and drug resistance, as well as inhibit the proliferation of disseminated tumor cells to form metastases.

JOURNAL OF CELL SCIENCE (2021)

Review Pharmacology & Pharmacy

Endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity may be therapeutically targeted by natural and chemical compounds: A review

Fatemeh Yarmohammadi et al.

Summary: Doxorubicin is a chemotherapeutic agent with dose-dependent cardiotoxicity, which can lead to arrhythmia and heart failure. Studies have shown that induction of endoplasmic reticulum stress signaling pathways may contribute to cardiac complications induced by Doxorubicin.

PHARMACOLOGICAL RESEARCH (2021)

Review Cell Biology

mTORC2: The other mTOR in autophagy regulation

Josue Ballesteros-Alvarez et al.

Summary: mTOR is a crucial kinase with two core complexes, mTORC1 and mTORC2, which regulate cell responses through different pathways. While mTORC1 is known for negatively regulating endosomal biogenesis and autophagy, the role of mTORC2 in autophagy regulation is less studied but potentially complementary to mTORC1.

AGING CELL (2021)

Review Biochemistry & Molecular Biology

Autophagy Modulators in Cancer Therapy

Kamila Buzun et al.

Summary: Autophagy is a self-degradation process that plays a crucial role in cell survival under stressful conditions. Recent research has focused on understanding the different types and mechanisms of autophagy, as well as the relationship between autophagy and apoptosis. Intensive studies have identified novel compounds with anticancer activity that can modulate autophagy pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Endoplasmic reticulum stress signals in the tumour and its microenvironment

Xi Chen et al.

Summary: This review explores how ER stress in the tumor microenvironment can influence the functions of cancer cells and immune cells, leading to vulnerabilities that could be targeted by emerging therapeutic strategies. The tightly regulated processes of protein handling, modification, and folding in the ER determine cell function and survival, and disruptions in ER homeostasis can result in a state of persistent ER stress with pro-tumoral effects in cancer cells and immunomodulatory effects in immune cells.

NATURE REVIEWS CANCER (2021)

Article Chemistry, Multidisciplinary

Inducing endoplasmic reticulum stress in cancer cells using graphene oxide-based nanoparticles

Shalini Pandey et al.

NANOSCALE ADVANCES (2020)

Article Nanoscience & Nanotechnology

Lipid Nanoparticle-Mediated Induction of Endoplasmic Reticulum Stress in Cancer Cells

Chandramouli Ghosh et al.

ACS APPLIED BIO MATERIALS (2019)

Review Biochemistry & Molecular Biology

Autophagy in cancer metastasis

E. E. Mowers et al.

ONCOGENE (2017)

Article Biochemistry & Molecular Biology

Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemosensitization towards oxaliplatin through inducing pro-death autophagy

Shengchao Lin et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)

Review Cell Biology

Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

Shuling Song et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

Article Chemistry, Multidisciplinary

Bioinspired butyrate-functionalized nanovehicles for targeted oral delivery of biomacromolecular drugs

Lei Wu et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Review Biotechnology & Applied Microbiology

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Lorenzo Galluzzi et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Review Cell Biology

Autophagy in natural and therapy-driven anticancer immunosurveillance

Federico Pietrocola et al.

AUTOPHAGY (2017)

Review Biochemistry & Molecular Biology

Emerging Biological Principles of Metastasis

Arthur W. Lambert et al.

Review Biochemistry & Molecular Biology

Autophagy inhibitors

Benoit Pasquier

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Review Biochemistry & Molecular Biology

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

Zhenyu Zhong et al.

Review Pathology

The Role of Endoplasmic Reticulum Stress in Human Pathology

Scott A. Oakes et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 10 (2015)

Review Pharmacology & Pharmacy

Current treatment strategies for inhibiting mTOR in cancer

Francesca Chiarini et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2015)

Article Medicine, Research & Experimental

Autophagy modulates endoplasmic reticulum stress-induced cell death in podocytes: A protective role

Yu-Chi Cheng et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2015)

Review Cell Biology

Molecular mechanisms of epithelial-mesenchymal transition

Samy Lamouille et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Review Pharmacology & Pharmacy

'How can I halt thee?' The puzzles involved in autophagic inhibition

V. Vinod et al.

PHARMACOLOGICAL RESEARCH (2014)

Review Pharmacology & Pharmacy

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

Ken Inoki et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 (2012)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth Control and Disease

Mathieu Laplante et al.

Article Biochemistry & Molecular Biology

Functional Cooperation between Snail1 and Twist in the Regulation of ZEB1 Expression during Epithelial to Mesenchymal Transition

Natlia Dave et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β, and Bcl-2

Maria Hoyer-Hansen et al.

MOLECULAR CELL (2007)