4.8 Article

Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia

Hannah J. Uckelmann et al.

Summary: The dysregulation of developmental and stem cell-associated genes is a common phenomenon during cancer development. Most patients with acute myeloid leukemia (AML) express high levels of HOXA cluster genes and MEIS1, with an NPM1 mutation (NPM1c) being common in these cases. This study reveals that NPM1c directly binds to specific chromatin targets, collaborates with the MLL1 complex, and directly regulates oncogenic gene expression in AML.

CANCER DISCOVERY (2023)

Article Oncology

3-Ketodihydrosphingosine reductase maintains ER homeostasis and unfolded protein response in leukemia

Qiao Liu et al.

Summary: The study identified KDSR as essential for leukemia cell maintenance, with its loss causing apoptosis, cell cycle arrest, and aberrant ER structure. Transcriptomic analysis revealed the crucial role of KDSR in maintaining the unfolded protein response in ER. Mechanistically, depletion of KDSR led to dysregulation of UPR checkpoint proteins and accumulation of 3-ketodihydrosphingosine, pointing to the therapeutic potential of targeting sphingolipid metabolism and ER homeostasis in leukemia treatment.

LEUKEMIA (2022)

Article Multidisciplinary Sciences

ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner

Xiaobao Xu et al.

Summary: Epigenetic dysregulation of cell cycle is a characteristic of tumorigenesis in various cancers, including hepatocellular carcinoma. The study identified ACTR5 as an essential component for HCC tumor progression. Suppression of ACTR5 affected cell cycle signaling and inhibited HCC tumor growth. The study also revealed a distinct usage of ACTR5 and IES6 in HCC compared to other INO80 complex members, suggesting a unique mechanism for ACTR5/IES6 in supporting HCC proliferation. The findings suggest that targeting ACTR5/IES6 in combination with CDK inhibition may be a promising approach for HCC therapy.

SCIENCE ADVANCES (2022)

Review Biochemistry & Molecular Biology

Epigenetic and Transcriptional Signaling in Ewing Sarcoma-Disease Etiology and Therapeutic Opportunities

Mingli Li et al.

Summary: This review discusses the epigenetic and transcriptional alterations in Ewing sarcoma and summarizes the relevant screening studies conducted to develop novel therapies.

BIOMEDICINES (2022)

Article Oncology

The Clinical and Prognostic Characteristics of Primary Salivary Gland-Type Carcinoma in the Lung: A Population-Based Study

Lei-Lei Wu et al.

Summary: This study explores the clinical and prognostic characteristics of primary salivary gland-type carcinoma (SGC). The findings show that SGC has the best prognosis among different histological types of lung cancer, and lobectomy can further improve the survival of SGC patients. The study provides important insights into the understanding and management of SGC.

CANCERS (2022)

Article Medicine, Research & Experimental

Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells

Rob S. Sellar et al.

Summary: Targeted protein degradation, specifically degrading GSPT1, shows promise in cancer treatment, particularly acute myeloid leukemia. The study reveals the mechanism of GSPT1 degradation leading to impaired translation termination, activation of the integrated stress response, and cell death. The identification of key amino acids preventing GSPT1 degradation in mice and the efficacy of GSPT1-degrading drugs in vivo highlight the potential for cancer therapy.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Review Medicine, General & Internal

Ewing's Sarcoma

Nicolo Riggi et al.

Summary: Ewing's sarcoma is an aggressive cancer that primarily affects children and young adults. In 85 to 90% of cases, a t(11;22) translocation is present. Treatment typically involves surgery, radiotherapy, and chemotherapy, with a 5-year survival rate of around 70%.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Genetics & Heredity

A first-generation pediatric cancer dependency map

Neekesh Dharia et al.

Summary: A pediatric cancer dependency map was created using genome-scale CRISPR-Cas9 loss-of-function screens in 82 pediatric cancer cell lines, revealing genetic dependencies across various tumor types. Contrary to the belief that pediatric cancers have fewer mutations, it was found that genetic dependencies in pediatric cancer cell lines are similarly complex as in adult models, indicating new therapeutic targets for childhood cancers.

NATURE GENETICS (2021)

Article Oncology

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma

Bo Kyung A. Seong et al.

Summary: Fusion-transcription factors (fusion-TFs) are difficult to therapeutically target, but recent research has discovered TRIM8 as a selective E3 ubiquitin ligase for degrading a driver fusion-TF in Ewing sarcoma. Knocking out TRIM8 leads to increased levels of the fusion TF, EWS/FLI, providing a potential strategy for exploiting oncogene overdose in Ewing sarcoma and other fusion-TF driven cancers.

CANCER CELL (2021)

Article Multidisciplinary Sciences

High-resolution characterization of gene function using single-cell CRISPR tiling screen

Lu Yang et al.

Summary: The authors introduce a new single-cell high-density CRISPR screening method, sc-Tiling, to identify functional domains and genetic regulatory mechanisms. This approach allows for the identification of regulatory mechanisms within a gene-coding region that dictate gene activity and therapeutic response.

NATURE COMMUNICATIONS (2021)

Review Oncology

MYC protein interactors in gene transcription and cancer

Corey Lourenco et al.

Summary: The transcription factor and oncoprotein MYC plays a critical role in many human cancers, with its ability to interact with multiple proteins enabling it to regulate key control points of gene transcription. This 'coalition model' of protein interactions allows MYC to function as a potent oncoprotein, and provides a potential therapeutic target for impeding MYC oncogenesis.

NATURE REVIEWS CANCER (2021)

Article Multidisciplinary Sciences

Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia

Hannah J. Uckelmann et al.

SCIENCE (2020)

Review Cell Biology

Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions

Anthony K. N. Chan et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Multidisciplinary Sciences

De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens

Wei He et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity

Victoria A. Assimon et al.

ACS CHEMICAL BIOLOGY (2019)

Article Multidisciplinary Sciences

TIP60/KAT5 is required for neuronal viability in hippocampal CA1

Inga Urban et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis

Shuo Liu et al.

Article Biochemistry & Molecular Biology

Cryo-EM structures of the human INO80 chromatin-remodeling complex

Ricardo J. Aramayo et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Cryo-EM structures of the human INO80 chromatin-remodeling complex

Ricardo J. Aramayo et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Oncology

EWS/ETS-Driven Ewing Sarcoma Requires BET Bromodomain Proteins

Paradesi Naidu Gollavilli et al.

CANCER RESEARCH (2018)

Review Cell Biology

Roadblocks and resolutions in eukaryotic translation

Anthony P. Schuller et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex

Xuejuan Wang et al.

NATURE COMMUNICATIONS (2018)

Article Medicine, General & Internal

Ewing sarcoma

Thomas G. P. Gruenewald et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Article Biotechnology & Applied Microbiology

CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis

Vivien A. C. Schoonenberg et al.

GENOME BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Targeting oncogenic Myc as a strategy for cancer treatment

Hui Chen et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2018)

Review Biochemistry & Molecular Biology

CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine

Martin Kampmann

ACS CHEMICAL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma

Nathan C. Sheffield et al.

NATURE MEDICINE (2017)

Article Biochemistry & Molecular Biology

Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain

Gaylor Boulay et al.

Article Biochemistry & Molecular Biology

Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes

Sichen Shao et al.

Article Biochemistry & Molecular Biology

The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism

Peng Xu et al.

MOLECULAR CELL (2016)

Article Biotechnology & Applied Microbiology

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench et al.

NATURE BIOTECHNOLOGY (2016)

Article Multidisciplinary Sciences

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Matthew C. Canver et al.

NATURE (2015)

Article Biotechnology & Applied Microbiology

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

Junwei Shi et al.

NATURE BIOTECHNOLOGY (2015)

Review Oncology

MYC, Metabolism, and Cancer

Zachary E. Stine et al.

CANCER DISCOVERY (2015)

Article Oncology

Oncogenic Protein MTBP Interacts with MYC to Promote Tumorigenesis

Brian C. Grieb et al.

CANCER RESEARCH (2014)

Letter Biochemical Research Methods

Improved vectors and genome-wide libraries for CRISPR screening

Neville E. Sanjana et al.

NATURE METHODS (2014)

Article Biochemistry & Molecular Biology

Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases

Eeson Rajendra et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Oncology

The Genomic Landscape of Pediatric Ewing Sarcoma

Brian D. Crompton et al.

CANCER DISCOVERY (2014)

Article Biotechnology & Applied Microbiology

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Wei Li et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Biochemistry & Molecular Biology

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Jakob Loven et al.

Article Biochemistry & Molecular Biology

Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer

Sven Bilke et al.

GENOME RESEARCH (2013)

Article Biochemical Research Methods

CRISPR interference (CRISPRi) for sequence-specific control of gene expression

Matthew H. Larson et al.

NATURE PROTOCOLS (2013)

Review Biology

Chaperone-like activity of the AAA+ proteins Rvb1 and Rvb2 in the assembly of various complexes

Nardin Nano et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2013)

Article Oncology

c-Myc and Cancer Metabolism

Donald M. Miller et al.

CLINICAL CANCER RESEARCH (2012)

Article Multidisciplinary Sciences

Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer

Kelly Coffey et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber et al.

NATURE (2011)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Biochemical Research Methods

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

Brendan MacLean et al.

BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

AAA plus Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay

Natsuko Izumi et al.

SCIENCE SIGNALING (2010)

Review Biochemistry & Molecular Biology

RVB1/RVB2: Running Rings around Molecular Biology

Sudhakar Jha et al.

MOLECULAR CELL (2009)

Article Multidisciplinary Sciences

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

Guenther H. S. Richter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biotechnology & Applied Microbiology

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Ben Langmead et al.

GENOME BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

Andrew S. Venteicher et al.

Article Multidisciplinary Sciences

Microsatellites as EWIS/FLI response elements in Ewing's sarcoma

Kunal Gangwal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Cell Biology

Control of transcription by pontin and reptin

Peter Gallant

TRENDS IN CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

c-Myc over-expression in Ramos Burkitt's lymphoma cell line predisposes to iron homeostasis disruption in vitro

ME Habel et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development

P Bellosta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans

Y Doyon et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

MYC recruits the TIP60 histone acetyltransferase complex to chromatin

SR Frank et al.

EMBO REPORTS (2003)

Article Biochemistry & Molecular Biology

TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis

KA Dugan et al.

ONCOGENE (2002)

Article Biochemistry & Molecular Biology

Myc requires distinct E2F activities to induce S phase and apoptosis

G Leone et al.

MOLECULAR CELL (2001)

Article Biochemistry & Molecular Biology

An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc

MA Wood et al.

MOLECULAR CELL (2000)