4.8 Article

Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pathology

Pathogenesis of Triple-Negative Breast Cancer

Fatemeh Derakhshan et al.

Summary: This article introduces the heterogeneity of triple-negative breast cancer (TNBC) and discusses its histologic, molecular classifications, and genomic alterations. The article also explores the role of the tumor microenvironment in TNBC and its potential impact on therapeutic response. Understanding the biology of each TNBC subtype is essential for delivering personalized medicine to patients.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

Review Oncology

Treatment landscape of triple-negative breast cancer - expanded options, evolving needs

Giampaolo Bianchini et al.

Summary: Recent advances in omics technologies have improved our understanding of the heterogeneity and microenvironment of triple-negative breast cancers (TNBCs), supporting a view of this breast cancer subtype as an ecosystem that encompasses both intrinsic and extrinsic features of cancer cells. The authors of this Review describe the current and upcoming therapeutic landscape of TNBC and discuss how an integrated view of the TNBC ecosystem can provide improved opportunities for tailoring treatment.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

Article Chemistry, Multidisciplinary

Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple-Negative Breast Cancer

Zitong Zhao et al.

Summary: In this study, walking dead TNBC cells were developed by conjugating anti-PD-1 and doxorubicin-loaded liposomes onto cell corpses for temporal chemo-immunotherapy against lung metastasis. The walking dead TNBC cells improved drug accumulation and local retention in the lungs, reprogrammed the lung microenvironment, and prolonged overall survival in mice with lung metastasis.

ADVANCED MATERIALS (2022)

Article Oncology

ZEB1 induces N-cadherin expression in human glioblastoma and may alter patient survival

Hanna Goett et al.

Summary: The present study investigated the expression of EMT-related factors and cell cycle modulating kinase in GBM, and found that their expression levels were significantly higher in GBM compared to normal brain tissue. However, these expression levels were not associated with patient survival.

MOLECULAR AND CLINICAL ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

TPX2 mediates prostate cancer epithelial-mesenchymal transition through CDK1 regulated phosphorylation of ERK/GSK3β/SNAIL pathway

Boya Zhang et al.

Summary: High expression of TPX2 in high-grade prostate cancer is associated with poor prognosis and metastasis. Depletion of TPX2 can inhibit tumor growth and migration, making it a potential target for anti-tumor metastasis therapy.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

USP29 coordinates MYC and HIF1α stabilization to promote tumor metabolism and progression

Rongfu Tu et al.

Summary: The study identified that deubiquitinase USP29 plays a key role in stabilizing MYC and HIF1 alpha, essential for metabolic adaptation of tumor cells in different oxygen levels, highlighting it as a potential therapeutic target for cancer treatment.

ONCOGENE (2021)

Review Medicine, General & Internal

Breast cancer

Sibylle Loibl et al.

Summary: Breast cancer diagnosis and treatment have become increasingly complex, incorporating various biomarkers and neoadjuvant therapies, with de-escalation schemes for radiotherapy now becoming standard practice.

LANCET (2021)

Article Biochemistry & Molecular Biology

Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis

Arun Pandian Chandrasekaran et al.

Summary: USP29 stabilizes Cdc25A protein expression in cancer cells, promoting cell proliferation and invasion, while knockdown of USP29 results in cell cycle arrest and reduced tumor size.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration

Yixin Tong et al.

Summary: DPP3 plays an oncogene-like role in the development and progression of CRC by targeting CDK1, which is correlated with lymphatic metastasis, pathological stage, and number of positive lymph nodes. Downregulation of DPP3 inhibits cell proliferation, migration and promotes apoptosis by upregulating multiple apoptosis-related genes.

CELL DEATH & DISEASE (2021)

Letter Biochemistry & Molecular Biology

Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization

Yan-Hong Cui et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Multidisciplinary Sciences

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

Mami Yasukawa et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1

Yuekun Zhu et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Medicine, General & Internal

Breast Cancer Treatment A Review

Adrienne G. Waks et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Article Oncology

Breast cancer statistics, 2019

Carol E. DeSantis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Review Cell Biology

New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer

Anushka Dongre et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Cell Biology

EMT Transition States during Tumor Progression and Metastasis

Ievgenia Pastushenko et al.

TRENDS IN CELL BIOLOGY (2019)

Article Oncology

CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma

Dinoop Ravindran Menon et al.

CANCER RESEARCH (2018)

Article Medicine, General & Internal

Molecular alterations in triple-negative breast cancer-the road to new treatment strategies

Carsten Denkert et al.

LANCET (2017)

Article Multidisciplinary Sciences

Structure of PINK1 in complex with its substrate ubiquitin

Alexander F. Schubert et al.

NATURE (2017)

Article Multidisciplinary Sciences

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Tongzheng Liu et al.

NATURE COMMUNICATIONS (2017)

Review Biochemistry & Molecular Biology

EMT: 2016

M. Angela Nieto et al.

Article Biochemistry & Molecular Biology

The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation

Hong-Jen Lee et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

Devon A. Lawson et al.

NATURE (2015)

Review Cell Biology

Molecular mechanisms of epithelial-mesenchymal transition

Samy Lamouille et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions

Yuji Tokunaga et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Review Oncology

WNT signalling pathways as therapeutic targets in cancer

Jamie N. Anastas et al.

NATURE REVIEWS CANCER (2013)

Article Biochemistry & Molecular Biology

Phosphorylation-dependent activity of the deubiquitinase DUBA

Oscar W. Huang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Oncology

Cancer stem cells: an evolving concept

Long V. Nguyen et al.

NATURE REVIEWS CANCER (2012)

Article Oncology

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis

Mark A. Eckert et al.

CANCER CELL (2011)

Review Oncology

Triple-negative breast cancer: disease entity or title of convenience?

Lisa Carey et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

Review Oncology

The regulatory crosstalk between kinases and proteases in cancer

Carlos Lopez-Otin et al.

NATURE REVIEWS CANCER (2010)

Article Biochemistry & Molecular Biology

The epithelial-mesenchymal transition generates cells with properties of stem cells

Sendurai A. Mani et al.

Review Biochemistry & Molecular Biology

Wnt/β-catenin signaling in development and disease

Hans Clevers