期刊
ADVANCED SCIENCE
卷 10, 期 14, 页码 -出版社
WILEY
DOI: 10.1002/advs.202300504
关键词
bioresorbable materials; multichannel electrophysiology mapping; neural interfaces; organic electrochemical transistor; transient electronics
In this study, a thin, lightweight, soft, and multichannel neural interface based on an organic-electrochemical-transistor (OECT) network is presented. It offers continuous high-fidelity mapping of neural signals and autonomous degradation after stable operation. This technology has the potential to be widely used in neural interfaces and play an important role in the treatment and diagnosis of neurological disorders.
A critical challenge lies in the development of the next-generation neural interface, in mechanically tissue-compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradation after stable operation. Here, an ultrathin, lightweight, soft and multichannel neural interface is presented based on organic-electrochemical-transistor-(OECT)-based network, with capabilities of continuous high-fidelity mapping of neural signals and biosafety active degrading after performing functions. Such platform yields a high spatiotemporal resolution of 1.42 ms and 20 mu m, with signal-to-noise ratio up to approximate to 37 dB. The implantable OECT arrays can well establish stable functional neural interfaces, designed as fully biodegradable electronic platforms in vivo. Demonstrated applications of such OECT implants include real-time monitoring of electrical activities from the cortical surface of rats under various conditions (e.g., narcosis, epileptic seizure, and electric stimuli) and electrocorticography mapping from 100 channels. This technology offers general applicability in neural interfaces, with great potential utility in treatment/diagnosis of neurological disorders.
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