Enhanced Bacterial-Infected Wound Healing by Nitric Oxide-Releasing Topological Supramolecular Nanocarriers with Self-Optimized Cooperative Multi-Point Anchoring

Polymeric systems that provide cationic charges or biocide-release therapeutics are used to treat the bacteria-infected wound. However, most antibacterial polymers based on topologies with restricted molecular dynamics still do not satisfy the clinical requirements due to their limited antibacterial efficacy at safe concentrations in vivo. Here a NO-releasing topological supramolecular nanocarrier with rotatable and slidable molecular entities is reported to provide conformational freedom to promote the interactions between the carrier and the pathogenic microbes, hence greatly improving the antibacterial performance. With improved contacting-killing and efficient delivery of NO biocide from the molecularly dynamic cationic ligand design, the NO-loaded topological nanocarrier achieves excellent antibacterial and anti-biofilm effects via destroying the bacterial membrane and DNA. MRSA-infected rat model is also brought out to demonstrate its wound-healing effect with neglectable toxicity in vivo. Introducing flexible molecular motions into therapeutic polymeric systems is a general design to enhance the healing of a range of diseases.

Automated summary

A topological supramolecular nanocarrier that releases NO is reported to greatly improve antibacterial performance by providing conformational freedom for interactions between the carrier and pathogenic microbes. The NO-loaded topological nanocarrier achieves excellent antibacterial and anti-biofilm effects through destroying the bacterial membrane and DNA. The nanocarrier also demonstrates wound-healing effects in an MRSA-infected rat model with negligible toxicity. Introducing flexible molecular motions into therapeutic polymeric systems is a general design approach to enhance the healing of various diseases.