期刊
LANCET NEUROLOGY
卷 15, 期 3, 页码 332-342出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(15)00380-4
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资金
- ForeFront
- National Health and Medical Research Council of Australia (NHMRC) [1037746, 1003139]
- Australian Research Council Centre of Excellence in Cognition and its Disorders Memory Node [CE110001021]
- ARC Discovery Early Career Researcher Award [DE130100463]
- NHMRC Career Development Research Fellowship [1022684]
- Medical Research Council [MC_UU_12012/5/B] Funding Source: researchfish
Metabolic changes incorporating fluctuations in weight, insulin resistance, and cholesterol concentrations have been identified in several neurodegenerative disorders. Whether these changes result from the neurodegenerative process affecting brain regions necessary for metabolic regulation or whether they drive the degenerative process is unknown. Emerging evidence from epidemiological, clinical, pathological, and experimental studies emphasises a range of changes in eating behaviours and metabolism in amyotrophic lateral sderosis (ALS) and frontotemporal dementia (FTD). In ALS, metabolic changes have been linked to disease progression and prognosis. Furthermore, changes in eating behaviour that affect metabolism have been incorporated into the diagnostic criteria for FTD, which has some clinical and pathological overlap with ALS. Whether the distinct and shared metabolic and eating changes represent a component of the proposed spectrum of the two diseases is an intriguing possibility. Moreover, future research should aim to unravel the complex connections between eating, metabolism, and neurodegeneration in ALS and FTD, and aim to understand the potential for targeting modifiable risk factors in disease development and progression.
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