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Article
Oncology
Jian Zhan et al.
Summary: This study investigates the effective mechanism of HNF4G on pancreatic cancer cell functions through the IGF2BP2 transcription. HNF4G and IGF2BP2 expressions were up-regulated in pancreatic cancer. Interfering with HNF4G inhibited cell proliferative, invasive and migratory behaviors, and decreased PCNA and MMP2 expression. Mechanistically, HNF4G as a transcription factor binds to IGF2BP2 and promotes its expression. In vivo findings showed that interfering with HNF4G expression retarded the tumorigenic ability of pancreatic cancer cells.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lu Chen et al.
Summary: The hepatocyte nuclear factor 4 gamma (HNF4G) is up-regulated in colorectal cancer and is associated with worse prognosis. Inhibition of HNF4G expression significantly suppresses cell proliferation and promotes apoptosis. HNF4G is involved in colorectal cancer cell apoptosis through the caspase-dependent intrinsic pathway. Knockdown of HNF4G expression attenuates colorectal cancer growth and promotes apoptosis in an animal model.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jaime A. Castro-Mondragon et al.
Summary: JASPAR is an open-access database containing manually curated, non-redundant transcription factor binding profiles across six taxonomic groups. The latest release introduces new profiles for plants, vertebrates, urochordates, and insects, as well as new tools for TFBS enrichment analysis and data access. The database can be accessed through various platforms, including the JASPAR website, RESTful API, R/Bioconductor data package, and a new Python package pyJASPAR.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Romain Girard et al.
Summary: The transcription factor HNF4A plays a key role in controlling the metabolic features of several endodermal epithelia. This study reveals that intestinal HNF4A is not required for intestinal lipid metabolism, but unexpectedly influences whole-body energy expenditure in diet-induced obesity. Intestinal HNF4A is crucial for the fat-induced release of GIP, which regulates energy expenditure and plays a non-redundant role in whole-body lipid homeostasis. This research provides new insights into the regulatory circuit for body-fat management.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Jiaqi Liang et al.
Summary: This study used single-cell transcriptomic data to analyze the malignant-cell-specific genes in lung adenocarcinoma. Seventy genes involved in tumor biology were identified, and a predictive model with an accuracy of 96.1% was constructed. Further experiments confirmed the upregulation of IRX2, SPINK13, and CAPN8 in lung adenocarcinoma, suggesting their potential as therapeutic targets.
Article
Biotechnology & Applied Microbiology
Xin-Xin He et al.
Summary: The study demonstrates that HNF4G plays a crucial role in CRC progression by promoting cell proliferation via the PI3K/AKT pathway, and miR-766-3p inhibits cell proliferation by targeting HNF4G both in vitro and in vivo. Therapies targeting the miR-766-3p/HNF4G axis may provide new treatment options for CRC.
CANCER GENE THERAPY
(2022)
Article
Medicine, Research & Experimental
Qihai Sui et al.
Summary: This study aimed to investigate the causes of resistance to cisplatin, especially in lung adenocarcinoma, and provide guidance for treatment decisions in clinical practice. By analyzing data from Cancer Cell Line Encyclopedia, The Cancer Genome Atlas, and Zhongshan hospital affiliated to Fudan University, the study found that cisplatin resistance was associated with somatic mutations, mRNA expressions, miRNA expressions, metabolites, and methylation. The models created in this study can be used to predict the response and prognosis of patients receiving platinum-based chemotherapies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Guoshu Bi et al.
Summary: The study identified miR-6077 as a key driver of cisplatin/pemetrexed resistance in lung adenocarcinoma (LUAD). Overexpression of miR-6077 desensitized LUAD cells to cisplatin/pemetrexed by affecting cell cycle and ferroptosis, leading to cell death. This research provides a novel therapeutic strategy for overcoming chemoresistance in clinical practice.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Oncology
Lei Zhou et al.
Summary: Insulin-like growth factor I receptor (IGF1R) is frequently upregulated in breast cancer, and its aberrant activation can enhance tumor cell proliferation, cancer stemness, tumor relapse, metastasis, and chemotherapy resistance. This study identified long non-coding RNA (lncRNA) HULC as a key regulator of IGF1R in breast cancer cells. HULC activates the IGF1R signaling pathway by binding to the intragenic regulatory elements of the gene, promoting intra-chromosomal interactions and histone acetylation. Activation of the HULC-IGF1R/PI3K/AKT pathway leads to tumor resistance to cisplatin through increased expression of cancer stemness markers. In immunodeficient mice, stimulation of the HULC-IGF1R pathway promotes tumor metastasis.
Article
Immunology
Xuqiu Lei et al.
Summary: The expression of HNF4A in intestinal epithelial cells (IECs) is essential for the proper development and composition of the intraepithelial lymphocyte (IEL) compartment, as it regulates the expression of immune signaling molecules and shapes the IEL compartment to maintain intestinal homeostasis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Mengjun Zhang et al.
Summary: This study demonstrates the anti-tumor effects of polyethylenimine-caged platinum nanoclusters on cisplatin-resistant ovarian cancer cells, inhibiting proliferation and migration while promoting apoptosis. The study also validates the role of these nanoclusters in regulating autophagy through the PI3K-AKT-mTOR signaling pathway. These findings suggest the promising potential of platinum nanoclusters as a novel chemotherapeutic agent for cisplatin-resistant ovarian cancer.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Chengcheng Wang et al.
Summary: In PDAC, overexpression of HNF4G due to SMAD4 deficiency plays a critical oncogenic role in progression and metastasis, but may be a druggable target for Metformin treatment.
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Medicine, General & Internal
Meagan Miller et al.
Summary: Lung cancer remains a leading cause of cancer-related mortality worldwide, with non-small cell lung cancer being incurable for most patients. The optimal treatment for locally advanced NSCLC includes chemoradiation, while immunotherapy can be added for unresectable cases post-chemoradiation. Advances in targeted therapies and immunotherapy have transformed the landscape of NSCLC treatment.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Oncology
Yu-Shui Ma et al.
Summary: miR-320b suppresses lung cancer growth and angiogenesis by inhibiting HNF4G, IGF2BP2 and TK1.
Article
Multidisciplinary Sciences
Qinbo Cai et al.
Summary: The study revealed that MAPK6 activates AKT independently of mTORC2, potentially providing a major resistance pathway in cancer. Inhibiting MAPK6 sensitized cancer cells to mTOR kinase inhibitors. Overexpression of MAPK6 is associated with decreased overall survival in various cancer patients.
Review
Biochemistry & Molecular Biology
Panpan Lv et al.
Summary: Platinum resistance is a challenge in lung cancer treatment, and understanding its molecular mechanisms, identifying predictive markers, and developing more effective and less toxic agents are crucial. Addressing this issue could lead to the development of improved treatment for refractory lung cancer in the future.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Biochemistry & Molecular Biology
Balazs Gyorffy
Summary: This study presents a ranking of all survival-related genes in chemotherapy treated basal and estrogen positive/HER2 negative breast cancer, providing a reference for future biomarker research. By analyzing hazard rates and p values of genes, the most promising prognostic genes can be identified, helping to focus research on candidates with the most clinical significance.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Lei Chen et al.
Article
Biochemistry & Molecular Biology
Yunhai Luo et al.
NUCLEIC ACIDS RESEARCH
(2020)
Article
Genetics & Heredity
Lei Chen et al.
Article
Oncology
Tao Lu et al.
CANCER MANAGEMENT AND RESEARCH
(2019)
Review
Oncology
Zhengyang Hu et al.
TRANSLATIONAL LUNG CANCER RESEARCH
(2019)
Article
Medicine, General & Internal
Claudia Allemani et al.
Article
Biochemistry & Molecular Biology
Zefang Tang et al.
NUCLEIC ACIDS RESEARCH
(2017)
Article
Jingyu Wang et al.
Article
Biochemistry & Molecular Biology
Matthew G. Rees et al.
NATURE CHEMICAL BIOLOGY
(2016)
Article
Multidisciplinary Sciences
Jordi Barretina et al.
