The Ethical Status of Germline Gene Editing in Future Space Missions: The Special Case of Positive Selection on Earth for Future Space Missions

Review Immunology

CCR5 as a Coreceptor for Human Immunodeficiency Virus and Simian Immunodeficiency Viruses: A Prototypic Love-Hate Affair

Anna J. Jasinska et al.

Summary: CCR5 is a chemokine receptor that plays a central role in immune responses and inflammation. It is involved in the pathogenesis of various health conditions, including HIV infection. Natural loss-of-function mutations of CCR5 can render individuals resistant to HIV. In addition, many African nonhuman primate species have developed strategies to minimize the effects of SIV infection by modulating CCR5 activity.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Ethics

Reproductive Embryo Editing: Attending to Justice

Inmaculada De Melo-Martin

Summary: This article argues that accepting the goal of using embryonic genome editing tools for ensuring healthy and genetically related children commits one to rejecting the use of social resources for further development of embryo editing for reproductive purposes, as there are safer and more effective means available.

HASTINGS CENTER REPORT (2022)

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Review Astronomy & Astrophysics

Android Noahs and embryo Arks: ectogenesis in global catastrophe survival and space colonization

Matthew R. Edwards

Summary: Successful development of AU systems in the short term will provide new avenues for clinical assistance and reproductive choices for prospective parents; in the long term, combining embryos and androids could partly or completely replace adult crew members in space colonization, advancing humanity's re-settlement in the universe.

INTERNATIONAL JOURNAL OF ASTROBIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Heritable human genome editing: Research progress, ethical considerations, and hurdles to clinical practice

Jenna Turocy et al.

Summary: Our genome at conception determines much of our health as an adult, with most diseases having a heritable component that may be preventable through heritable genome editing. While preventing disease from the beginning of life is a commendable goal, there are significant hurdles that must be overcome before translating these technologies into clinical practice.

CELL (2021)

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Article Economics

Future space missions and human enhancement: Medical and ethical challenges

Konrad Szocik et al.

Summary: Future human space missions to Mars and beyond may be realized for various reasons, requiring the development of effective countermeasures due to the hazardous environment of space. This paper discusses the prospects of human enhancement through gene editing, synthetic biology, or implants for the purpose of long-term space exploration, presenting ethical arguments in favor of such enhancements.

FUTURES (2021)

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Editorial Material Biochemistry & Molecular Biology