期刊
MULTIPLE SCLEROSIS AND RELATED DISORDERS
卷 71, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.msard.2023.104579
关键词
Language; Multiple sclerosis; Naming; Neuropsychological assessment; Word finding
The prevalence of naming impairment in patients with multiple sclerosis (pwMS) was examined using a measure of confrontation naming, and correlates with neuroimaging were identified. The results showed that naming difficulties are common in pwMS and are more strongly associated with neuroimaging of MS brain pathology.
Background: Naming difficulty is commonly reported by patients with multiple sclerosis (pwMS). Though many cognitive batteries recommended for pwMS include fluency tasks, they do not include naming tasks. The aim of this study was to examine the prevalence of naming impairment in pwMS by using a measure of confrontation naming and to identify correlates with neuroimaging.Methods: One-hundred-eighty-five pwMS (Mage = 48.75 +/- 11.23) completed neuropsychological testing and fifty had brain MRI scans within one year of neuropsychological testing. Controlling for demographic variables, partial correlations and hierarchical regressions with language tests as the outcome variables and neuroimaging variables as predictors were performed.Results: Performance on language tasks ranged within low average to average, with impairment most frequently found on a measure of confrontation naming (Boston Naming Test [BNT];27.6%), followed by a measure of phonemic fluency (Controlled Oral Word Association Test [COWAT]; 24.3%) and semantic fluency (animals [AF]; 18.3%). In the subset of patients with neuroimaging, thalamic volume had the strongest relationship with language variables, followed by white matter volume and T2 lesion volume. Language variables had no asso-ciation with fractional gray matter volume. Of the language measures, BNT demonstrated the strongest rela-tionship with MRI variables, followed by AF. There were no significant associations between neuroimaging variables and COWAT. Regression results revealed that fractional thalamic volume significantly contributed to BNT scores after adjusting for demographics, while T2 lesion volume predicted AF and no neuroimaging vari-ables emerged as predictors for COWAT after controlling for demographics.Conclusions: Objective naming impairment is common in pwMS and are more strongly associated with neuro-imaging of MS brain pathology than verbal fluency tasks that are commonly used in cognitive batteries for pwMS. Continued research on language (especially naming) deficits and neuroimaging correlates (particularly thalamic involvement) in pwMS is needed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据