Safety and immunogenicity of heterologous boosting with orally aerosolised or intramuscular Ad5-nCoV vaccine and homologous boosting with inactivated vaccines (BBIBP-CorV or CoronaVac) in children and adolescents: a randomised, open-label, parallel-c...

Article Multidisciplinary Sciences

Local and systemic responses to SARS-CoV-2 infection in children and adults

Masahiro Yoshida et al.

Summary: Higher innate interferon responses in children may restrict viral replication and disease progression, while the response to SARS-CoV-2 infection differs between children and adults.

NATURE (2022)

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Article Medicine, General & Internal

Covid-19 Vaccine Effectiveness in New York State

Eli S. Rosenberg et al.

Summary: The effectiveness of the BNT162b2, mRNA-1273, and Ad26.COV2.S vaccines in New York State from May to August 2021 was assessed. Initial protection was high, but there was a modest decline in effectiveness after the surge of the delta variant, especially among recipients aged 65 and older. However, protection against hospitalization remained high.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Letter Immunology

Safety, mucosal and systemic immunopotency of an aerosolized adenovirus-vectored vaccine against SARS-CoV-2 in rhesus macaques

Fang Xu et al.

Summary: The study examined the safety and immunogenicity of a vaccine administered through nebulization inhalation in rhesus macaques. The results showed that this method effectively induced immune responses against SARS-CoV-2 and had minimal adverse effects. This study highlights the potential importance of vaccination through nebulization inhalation for controlling SARS-CoV-2.

EMERGING MICROBES & INFECTIONS (2022)

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Article Multidisciplinary Sciences

High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection

Eva-Maria Jacobsen et al.

Summary: The severity and immune response of SARS-CoV-2 infection differ in adults and children. Children show a plasmablast-driven initial response, enhanced specific antibody response, and lower but detectable specific B and T cell responses compared to their parents. After one year, children exhibit an increase in S1-specific IgA class switch and enhanced T cell maturation.

NATURE COMMUNICATIONS (2022)

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Article Critical Care Medicine

Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: a randomised, open-label, single-centre trial

Jing-Xin Li et al.

Summary: In a randomized controlled trial, researchers found that heterologous boost immunization with an orally administered aerosolized adenovirus-based COVID-19 vaccine is safe and highly immunogenic in adults previously primed with two doses of an inactivated COVID-19 vaccine.

LANCET RESPIRATORY MEDICINE (2022)

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Article Multidisciplinary Sciences

Immunogenicity and efficacy of heterologous ChAdOx1-BNT162b2 vaccination

Bruno Pozzetto et al.

Summary: The study found that a heterologous vaccination regimen using ChAdOx1-S-nCoV-19 and BNT162b2 can provide better protection against SARS-CoV-2 infection with stronger neutralizing activity. This approach can activate memory B cells that recognize SARS-CoV-2, making it suitable for immunocompromised individuals.

NATURE (2021)

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Review Infectious Diseases

Mucosal immunity to severe acute respiratory syndrome coronavirus 2 infection

Janeri Froberg et al.

Summary: Mucosal immune responses play a crucial role in early restriction of viral replication and clearance of SARS-CoV-2, with strong correlations observed between mucosal antibody responses and virus neutralization. Further studies are needed to understand how systemic immunological endpoints measured in vaccination studies translate to mucosal protection against SARS-CoV-2 infection.

CURRENT OPINION IN INFECTIOUS DISEASES (2021)

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Review Virology

Safety and effectiveness of SARS-CoV-2 vaccines: A systematic review and meta-analysis

Yunzhi Ling et al.

Summary: The study found that the incidence of adverse reactions of SARS-CoV-2 vaccines currently undergoing clinical trials is high, with common adverse reactions being pain, swelling, and fever at the injection site. From the perspective of effectiveness and safety, RNA vaccines perform the best among the three types of vaccines.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Medicine, General & Internal

Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial

Xinxue Liu et al.

Summary: Heterologous prime-boost COVID-19 vaccine schedules could facilitate mass immunisation, with ChAd/BNT showing non-inferior immunogenicity compared to ChAd/ChAd, but BNT/ChAd did not demonstrate non-inferiority to BNT/BNT. The results support flexibility in using heterologous prime-boost vaccination with ChAd and BNT COVID-19 vaccines.

LANCET (2021)

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Article Infectious Diseases

Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial

Shipo Wu et al.

Summary: The study evaluated the safety and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine in adults without COVID-19 from China. It found that the aerosol vaccine was well tolerated, and two doses elicited neutralising antibody responses similar to one dose of intramuscular injection. An aerosolised booster vaccination at 28 days after the first intramuscular injection induced strong IgG and neutralising antibody responses. The efficacy and cost-effectiveness of aerosol vaccination should be evaluated in future studies.

LANCET INFECTIOUS DISEASES (2021)

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Article Biochemistry & Molecular Biology

Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination

Tina Schmidt et al.

Summary: In healthy adults, vaccination with an mRNA vaccine as a booster, regardless of the initial vaccine, resulted in higher levels of spike-specific antibodies and T cells compared to booster vaccination with ChAdOx1 nCov-19. Heterologous vaccination with ChAdOx1 nCoV-19 followed by an mRNA vaccine induced strong immune responses with acceptable reactogenicity, showing similar or better effects than homologous mRNA vaccine regimens.

NATURE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Joana Barros-Martins et al.

Summary: A study found that booster vaccination with BNT162b2 in healthcare professionals previously vaccinated with ChAdOx-1 nCoV-19 elicited more neutralizing antibodies and higher frequencies of virus-specific T cells. Additionally, BNT162b2 induced high titers of neutralizing antibodies against variants of concern, such as B.1.1.7, B.1.351, and P.1.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Effectiveness of mRNA Covid-19 Vaccine among US Health Care Personnel

T. Pilishvili et al.

Summary: The BNT162b2 and mRNA-1273 vaccines were highly effective in preventing symptomatic Covid-19 in U.S. health care personnel, with vaccine effectiveness of 77.6% to 96.3%. The effectiveness was consistent across different subgroups defined by age, race and ethnic group, underlying conditions, and patient contact levels, indicating the vaccines were effective for preventing Covid-19 in those at risk and in disproportionately affected groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel

Yinon M. Bar-On et al.

Summary: After receiving a third dose of the BNT162b2 mRNA vaccine, Israeli residents aged 60 and above who had previously received two doses of the vaccine saw significantly lower rates of confirmed Covid-19 infection and severe illness compared to those who did not receive a booster shot, indicating the effectiveness of the booster dose in reducing infection and severe illness.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Hematology

Are We Forgetting About IgA? A Re-examination of Coronavirus Disease 2019 Convalescent Plasma

Hans Verkerke et al.

Summary: The study found that increased IgA anti-SARS-CoV-2 antibody levels correlated with clinical improvement and viral clearance in an infant with COVID-19. IgA levels showed significant heterogeneity among CP donors and hospitalized patients, weakly correlated with IgG levels or commonly employed serological tests.

TRANSFUSION (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection

Carolyn A. Cohen et al.

Summary: This study shows that infected children have lower CD4(+) and CD8(+) T cell responses to SARS-CoV-2 proteins compared to infected adults. Children also have reduced CD4(+) T cell effector memory but comparable T cell polyfunctionality.

NATURE COMMUNICATIONS (2021)

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Article Public, Environmental & Occupational Health

Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021

Catherine M. Brown et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Cell Biology

Immune system development varies according to age, location, and anemia in African children

Danika L. Hill et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Medicine, General & Internal

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

Feng-Cai Zhu et al.

LANCET (2020)

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Review Pharmacology & Pharmacy

The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation

Jieliang Wang et al.

AAPS PHARMSCITECH (2020)

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Article Cell Biology

Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

Carl A. Pierce et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Multidisciplinary Sciences

Differences in the influenza-specific CD4 T cell immunodominance hierarchy and functional potential between children and young adults

Ian Shannon et al.

SCIENTIFIC REPORTS (2019)

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Article Biochemistry & Molecular Biology

The Unexplored Roles of Human Serum IgA

Ka Wai Leong et al.

DNA AND CELL BIOLOGY (2014)

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Article Immunology

FcαRI-Mediated Inhibition of IL-12 Production and Priming by IFN-γ of Human Monocytes and Dendritic Cells

Marylene Lecocq et al.

JOURNAL OF IMMUNOLOGY (2013)

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Safety and immunogenicity of heterologous boosting with orally aerosolised or intramuscular Ad5-nCoV vaccine and homologous boosting with inactivated vaccines (BBIBP-CorV or CoronaVac) in children and adolescents: a randomised, open-label, parallel-controlled, non- inferiority, single-centre study

相关参考文献

Local and systemic responses to SARS-CoV-2 infection in children and adults

Covid-19 Vaccine Effectiveness in New York State

Safety, mucosal and systemic immunopotency of an aerosolized adenovirus-vectored vaccine against SARS-CoV-2 in rhesus macaques

High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection

Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: a randomised, open-label, single-centre trial

Immunogenicity and efficacy of heterologous ChAdOx1-BNT162b2 vaccination

Mucosal immunity to severe acute respiratory syndrome coronavirus 2 infection

Safety and effectiveness of SARS-CoV-2 vaccines: A systematic review and meta-analysis

Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial

Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial

Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination

Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Effectiveness of mRNA Covid-19 Vaccine among US Health Care Personnel

Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel

Are We Forgetting About IgA? A Re-examination of Coronavirus Disease 2019 Convalescent Plasma

SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection

Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021

Immune system development varies according to age, location, and anemia in African children

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation

Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

Differences in the influenza-specific CD4 T cell immunodominance hierarchy and functional potential between children and young adults

The Unexplored Roles of Human Serum IgA

FcαRI-Mediated Inhibition of IL-12 Production and Priming by IFN-γ of Human Monocytes and Dendritic Cells

Safety and immunogenicity of heterologous boosting with orally aerosolised or intramuscular Ad5-nCoV vaccine and homologous boosting with inactivated vaccines (BBIBP-CorV or CoronaVac) in children and adolescents: a randomised, open-label, parallel-controlled, non- inferiority, single-centre study

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