4.6 Editorial Material

Vitamin D and fractures

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Article Endocrinology & Metabolism

The effect of monthly vitamin D supplementation on fractures: a tertiary outcome from the population-based, double-blind, randomised, placebo-controlled D-Health trial

Mary Waterhouse et al.

Summary: This study investigated whether supplementing Australian adults with monthly doses of 60,000 IU vitamin D3 for up to 5 years altered the rate of fractures. The results showed that vitamin D supplementation did not increase fracture risk, and long-term supplementation might reduce the incidence of total fractures. However, further research is needed to confirm this effect.

LANCET DIABETES & ENDOCRINOLOGY (2023)

Article Medicine, General & Internal

Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults

Meryl S. LeBoff et al.

Summary: The study found that supplementing with vitamin D3 does not significantly reduce the risk of fractures in generally healthy middle-aged and older adults, regardless of total, nonvertebral, or hip fractures.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Endocrinology & Metabolism

25-Hydroxyvitamin D Threshold for the Effects of Vitamin D Supplements on Bone Density: Secondary Analysis of a Randomized Controlled Trial

Helen M. Macdonald et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)