4.6 Article

Prenatal Environmental Stressors and DNA Methylation Levels in Placenta and Peripheral Tissues of Mothers and Neonates Evaluated by Applying Artificial Neural Networks

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Public, Environmental & Occupational Health

Select Early-Life Environmental Exposures and DNA Methylation in the Placenta

Michael Mortillo et al.

Summary: The purpose of this review is to summarize recent literature on the effects of early-life environmental exposures on placental DNA methylation, identify how variation in placental methylation is regulated in an exposure-specific manner, and encourage further research in this area. Multiple studies have found associations between prenatal environmental exposures and placental methylation at both gene-specific and epigenome-wide levels. Different exposures lead to unique patterns of methylation, and cross-exposure assessments have identified certain genes that consistently show differential placental methylation. Studies focusing on exposures such as air pollution, maternal smoking, environmental contaminants, and trace metals are more abundant, while studies on socioeconomic adversity and circadian disruption are scarce but show significant effects. Understanding the impacts of early-life environmental exposures on placental methylation is crucial for establishing the link between the maternal environment, epigenetic variation, and long-term health. Future studies should incorporate repeated measures of exposure throughout pregnancy to determine critical windows of heavy placental methylation effects. Methylation-based scores and sequencing technology could provide insights into epigenetic gestational age and identify more genomic regions affected by methylation. Studies on the impact of other exposures such as pesticides, alcohol, and other chemicals are also necessary.

CURRENT ENVIRONMENTAL HEALTH REPORTS (2023)

Article Cell Biology

Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure

Benjamin Laufer et al.

Summary: The study found that prenatal exposure to PCBs affects the DNA methylation profiles of mouse placenta and fetal brain. PCB-associated methylation regions are related to neurodevelopment and cellular signaling, and are enriched in bivalent chromatin regions. The overlapping PCB methylation regions in the placenta and fetal brain are associated with genes related to Wnt signaling, Slit/Robo signaling, and NDD. The findings demonstrate the potential harm of PCBs on fetal development.

CELL REPORTS (2022)

Article Genetics & Heredity

Extend mixed models to multilayer neural networks for genomic prediction including intermediate omics data

Tianjing Zhao et al.

Summary: With the increasing amount and diversity of intermediate omics data, there is a need to develop methods to incorporate them into genomic evaluation. The researchers developed a new method called NN-MM, which models the multiple layers of regulation from genotypes to intermediate omics features using a multilayer neural network. Compared to the recently proposed single-step approach, NN-MM provides better prediction performance for genomic prediction with intermediate omics data.

GENETICS (2022)

Article Biochemistry & Molecular Biology

Genomic map of candidate human imprint control regions: the imprintome

Dereje D. Jima et al.

Summary: This study identified potential imprint control regions (ICRs) in the human genome using whole-genome bisulphite sequencing. The researchers found that the methylation patterns of these regions are similar across different cell types and are located in known binding sites and hypersensitive regions. This research is of great importance for studying the mechanisms underlying human diseases and developmental and behavioral disorders.

EPIGENETICS (2022)

Article Genetics & Heredity

Artificial neural networks reveal sex differences in gene methylation, and connections between maternal risk factors and symptom severity in autism spectrum disorder

Andrea Stoccoro et al.

Summary: This study used artificial neural networks to examine the connections among blood gene methylation levels, sex, maternal risk factors, and symptom severity in children with autism spectrum disorder (ASD). The results showed that the methylation levels of MECP2, HTR1A, and OXTR genes were associated with females, while the methylation levels of EN2, BCL2, and RELN genes were associated with males. High gestational weight gain, lack of folic acid supplements, advanced maternal age, preterm birth, low birthweight, and living in a rural context were the best predictors of a high ADOS-2 score.

EPIGENOMICS (2022)

Article Public, Environmental & Occupational Health

Prenatal Maternal Smoke, DNA Methylation, and Multi-omics of Tissues and Child Health

Marta Cosin-Tomas et al.

Summary: Studies have shown that maternal smoking during pregnancy leads to changes in offspring's DNA methylation, with effects potentially lasting for years depending on the length and dosage of exposure. DNA methylation scores have been developed as biomarkers to estimate past exposure to maternal smoking during pregnancy.

CURRENT ENVIRONMENTAL HEALTH REPORTS (2022)

Review Public, Environmental & Occupational Health

The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis

Samantha Lapehn et al.

Summary: Placental epigenomics provides insights into the developmental origins of health and disease hypothesis by evaluating the impact of prenatal exposures on gene expression and DNA methylation in the placenta. Recent studies have connected various prenatal exposures to placental epigenetic changes, as well as health outcomes in infants and children.

CURRENT ENVIRONMENTAL HEALTH REPORTS (2022)

Article Environmental Sciences

Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort

Paulina Jedynak et al.

Summary: In utero exposure to synthetic phenols may lead to alterations in placental DNA methylation, with significant DMRs identified in genes related to important cellular functions and imprinted genes. Placental cell heterogeneity may mediate the effects of exposure on DNA methylation, suggesting potential mechanisms for how certain exposures can impact fetal development.

ENVIRONMENTAL POLLUTION (2021)

Article Multidisciplinary Sciences

Artificial neural network, predictor variables and sensitivity threshold for DNA methylation-based age prediction using blood samples

Zhonghui Thong et al.

Summary: Regression models and artificial neural network (ANN) models were evaluated for age prediction based on methylation patterns, with the ANN model showing higher accuracy. Ethnicity and sex had minimal impact on age prediction among local samples, and a one locus-based ANN model was effective in reducing DNA usage.

SCIENTIFIC REPORTS (2021)

Article Oncology

DNA methylation mediates the effect of maternal smoking on offspring birthweight: a birth cohort study of multi-ethnic US mother-newborn pairs

Richard Xu et al.

Summary: This study in a predominantly urban, low-income multi-ethnic birth cohort in the US found that maternal smoking significantly affects newborn birthweight, and fetal DNA methylation may play an important mediating role in the impact of maternal smoking on newborn birthweight.

CLINICAL EPIGENETICS (2021)

Article Biochemistry & Molecular Biology

Integrative Predictive Modeling of Metastasis in Melanoma Cancer Based on MicroRNA, mRNA, and DNA Methylation Data

Aysegul Kutlay et al.

Summary: This study focused on identifying the regulatory impact of genetic biomarkers for monitoring metastatic molecular signatures of melanoma by investigating the consolidated effect of miRNA, mRNA, and DNA methylation. Through integrating miRNA, mRNA, and DNA methylation markers, the study found that miRNA regulation plays a significant role in metastatic melanoma, and the integrated evaluation of miRNA with mRNA and methylation biomarkers increases the model's predictive power.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Review Health Care Sciences & Services

Salivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part II: A Cancer Risk Meta-Analysis

Oscar Rapado-Gonzalez et al.

Summary: Salivary gene promoter methylation plays an important role in the pathogenesis of head and neck cancer (HNC), with significantly higher frequency in HNC patients compared to healthy controls. Specific tumor-related genes such as p16, MGMT, DAPK, TIMP3, and RASSF1A were found to have a significant association with HNC risk. Therefore, detection of promoter DNA methylation in saliva could serve as a potential biomarker for predicting HNC risk.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Review Obstetrics & Gynecology

Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review

M. Dolores Gomez-Roig et al.

Summary: Preconception and prenatal exposure to environmental contaminants can have long-term effects on health, particularly during pregnancy, neonatal period, and childhood. Substances like alcohol and smoking can lead to fetal abnormalities and developmental issues, while endocrine-disrupting chemicals and heavy metals in food may alter hormone levels and impact fetal health. The growing evidence on the negative effects of air pollutants on pregnancy highlights the importance of considering environmental exposures as a major public health issue during pregnancy and breastfeeding.

FETAL DIAGNOSIS AND THERAPY (2021)

Article Biochemistry & Molecular Biology

Tissue and sex-specific programming of DNA methylation by perinatal lead exposure: implications for environmental epigenetics studies

Laurie K. Svoboda et al.

Summary: This study explores the sex-specific effects of perinatal exposure to Pb on DNA methylation in mice, finding thousands of differentially methylated cytosines, including imprinted loci, in both liver and blood tissues. Furthermore, a subset of Pb-altered genes exhibit basal sex differences in gene expression in the mouse liver, providing potential molecular targets for Pb-induced metabolic diseases and informing the design of more robust human environmental epigenomics studies.

EPIGENETICS (2021)

Article Pediatrics

Pediatric Acute-Onset Neuropsychiatric Syndrome: A Data Mining Approach to a Very Specific Constellation of Clinical Variables

Antonella Gagliano et al.

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY (2020)

Article Obstetrics & Gynecology

Expression level of long noncoding RNA H19 of normotensive placentas in late pregnancy relates to the fetal growth restriction

Youhei Tsunoda et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2020)

Article Genetics & Heredity

Maternal environmental exposure to bisphenols and epigenome-wide DNA methylation in infant cord blood

Carolyn F. McCabe et al.

ENVIRONMENTAL EPIGENETICS (2020)

Review Multidisciplinary Sciences

Advances in epigenetics link genetics to the environment and disease

Giacomo Cavalli et al.

NATURE (2019)

Review Biology

Genomic imprinting, growth and maternal-fetal interactions

Fearon C. Cassidy et al.

JOURNAL OF EXPERIMENTAL BIOLOGY (2018)

Review Developmental Biology

Involvement of leptin in the molecular physiology of the placenta

Malena Schanton et al.

REPRODUCTION (2018)

Article Environmental Sciences

High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study

Jennifer A. Rusiecki et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2017)

Review Nutrition & Dietetics

Developmental origins of health and disease: current knowledge and potential mechanisms

Daniel J. Hoffman et al.

NUTRITION REVIEWS (2017)

Article Biotechnology & Applied Microbiology

MGMT hypomethylation is associated with DNA damage in workers exposed to low-dose benzene

Jie Li et al.

BIOMARKERS (2017)

Article Genetics & Heredity

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Bonnie R. Joubert et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2016)

Review Obstetrics & Gynecology

Genomic imprinting in the human placenta

David Monk

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2015)

Article Environmental Sciences

Placental DNA Methylation Related to Both Infant Toenail Mercury and Adverse Neurobehavioral Outcomes

Jennifer Z. J. Maccani et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2015)

Article Biochemistry & Molecular Biology

Placental 5-methylcytosine and 5-hydroxymethylcytosine patterns associate with size at birth

Chinthika Piyasena et al.

EPIGENETICS (2015)

Article Biochemistry & Molecular Biology

Maternal prenatal depressive symptoms predict infant NR3C1 1F and BDNF IV DNA methylation

E. C. Braithwaite et al.

EPIGENETICS (2015)

Article Biochemistry & Molecular Biology

Placental expression profile of imprinted genes impacts birth weight

Maya A. Kappil et al.

EPIGENETICS (2015)

Article Endocrinology & Metabolism

IGF-II expression and methylation in small for gestational age infants

Shulian Zhang et al.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2015)

Article Obstetrics & Gynecology

Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation

Corina Lesseur et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2014)

Review Biochemistry & Molecular Biology

Imprinted and X-linked non-coding RNAs as potential regulators of human placental function

Sam Buckberry et al.

EPIGENETICS (2014)

Article Environmental Sciences

450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy

Bonnie R. Joubert et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2012)

Article Biochemistry & Molecular Biology

IGF2 DNA methylation is a modulator of newborn's fetal growth and development

Julie St-Pierre et al.

EPIGENETICS (2012)

Review Genetics & Heredity

Epigenetics and the environment: emerging patterns and implications

Robert Feil et al.

NATURE REVIEWS GENETICS (2012)

Article Clinical Neurology

Auto-Contractive Maps: An Artificial Adaptive System for Data Mining. An Application to Alzheimer Disease

Massimo Buscema et al.

CURRENT ALZHEIMER RESEARCH (2008)

Review Genetics & Heredity

Environmental epigenomics and disease susceptibility

Randy L. Jirtle et al.

NATURE REVIEWS GENETICS (2007)