期刊
CHEMCATCHEM
卷 7, 期 8, 页码 1275-1279出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201403019
关键词
allylamines; arenes; direct arylation; palladium; regioselectivity
资金
- National Natural Science Foundation of China [21072225, 21172258, 21372258, 91127039]
The Pd(OAc)(2)-catalyzed direct C-H bond olefination of unreactive arenes with allylamines in the presence of AgOAc was developed. A variety of allylamines including beta-substituted substrates underwent smooth coupling reactions with various arenes to give exclusively the terminal arylation products in high yields with excellent regioselectivities and stereoselectivities. The reaction is compatible with a range of functional groups in both coupling partners. The carbonyl group in the allylamine substrates is critical to catalysis, and the high regio- and stereocontrol observed is attributed to coordination between the carbonyl O and Pd atoms.
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