In silico analysis of the solute carrier (SLC) family in cancer indicates a link among DNA methylation, metabolic adaptation, drug response, and immune reactivity

Article Pathology

SLC34A2 promotes cancer proliferation and cell cycle progression by targeting TMPRSS3 in colorectal cancer

Yi Yang et al.

Summary: SLC34A2 was found to be overexpressed in colorectal cancer, promoting cell proliferation and cell cycle progression by targeting TMPRSS3.

PATHOLOGY RESEARCH AND PRACTICE (2022)

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Article Cell Biology

Amino Acid Metabolism in Cancer Drug Resistance

Hee-Chan Yoo et al.

Summary: This review highlights the crucial roles of amino acid metabolism in driving drug resistance in cancer cells. Amino acids support cancer cells in countering therapies and also impact anticancer immune responses.

CELLS (2022)

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Article Biochemistry & Molecular Biology

Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer

Bradley K. Schniers et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a dire need for better therapeutic targets. This study reveals that up-regulation of amino acid transporter SLC6A14 affects overall patient survival in PDAC. Pharmacological inhibition of SLC6A14 attenuates PDAC growth by inducing amino acid deprivation and inhibiting the mTORC1 signaling pathway.

BIOCHEMICAL JOURNAL (2022)

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Article Oncology

SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway

Zelin Liu et al.

Summary: This study found that SLC4A4 plays a promoting role in prostate cancer and is involved in the development and progression of PCa through regulating the AKT pathway. The overexpression of SLC4A4 is significantly correlated with disease progression in PCa. Knockdown of SLC4A4 inhibits cell proliferation, migration, and invasion in PCa, while promoting apoptosis.

CANCER CELL INTERNATIONAL (2022)

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Article Dermatology

Ablation of Proton/Glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis

Ye Liu et al.

Summary: Sequence variation in SLC45A2 is associated with oculocutaneous albinism type 4 and melanoma susceptibility. The study reveals that SLC45A2 plays a critical role in melanogenesis and melanoma metastasis. Slc45a2-deficient melanocytes have impaired activity of the key melanogenic enzyme tyrosinase due to the acidified cellular environment. SLC45A2 is identified as a proton/glucose exporter in melanosomes, and its deficiency leads to increased acidification of melanosomal pH through enhanced glycolysis. Additionally, Slc45a2 deficiency upregulates glycolytic enzymes and PI3K/AKT signaling, promoting glycolysis-dependent survival and metastasis of melanoma cells.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Review Cell Biology

Solute carrier transporters: emerging central players in tumour immunotherapy

Ruiqun Chen et al.

Summary: This review examines the emerging roles of solute carrier transporters (SLCs) in immunity, focusing on the impact of nutrient-related transporters on immune cell metabolism and effector functions. The potential strategies for targeting SLCs to enhance tumor immunotherapy are also discussed.

TRENDS IN CELL BIOLOGY (2022)

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Article Oncology

Defective expression of C20orf54 in esophageal dysplasia: a possible biomarker of esophageal carcinoma for early detection

Man Li et al.

Summary: This study provides the first evidence of defective expression of C20orf54 in esophageal squamous cell carcinoma (ESCC) and precancerous lesions, indicating its potential role in tumor progression and metastasis. C20orf54 could be used as a potential biomarker for early detection of ESCC.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2022)

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Review Oncology

The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer

Nidhi Jyotsana et al.

Summary: SLC7A11 is an antiporter that mediates the exchange of extracellular cystine for intracellular glutamate. It plays diverse functional roles in maintaining redox homeostasis and immune system function, and is associated with the development and drug resistance of diseases such as cancer. In this review, the focus is on discussing its molecular functions and therapeutic strategies in gastrointestinal cancers.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Blockade of the amino acid transporter SLC6A14 suppresses tumor growth in colorectal Cancer

Ying Lu et al.

Summary: SLC6A14 is upregulated in colorectal cancer (CRC) and promotes tumor progression by activating the Akt-mTOR signaling pathway. Inhibition of SLC6A14 reduces cell proliferation and migration in vitro and inhibits xenograft tumor growth in vivo. The findings suggest that SLC6A14 may serve as an effective molecular target for the treatment of CRC.

BMC CANCER (2022)

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Review Biochemistry & Molecular Biology

Methyl Group Metabolism in Differentiation, Aging, and Cancer

Lars Erichsen et al.

Summary: Methyl group metabolism plays a crucial role in cellular methylation reactions and DNA methylation, which are essential for various cellular functions. Stable and proper metabolic processes are important to prevent deficiencies and erosion of the methylome, as alterations can lead to epigenetic and genetic perturbations causing diverse disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Immunology

Integrated analysis of necroptosis-related genes for evaluating immune infiltration and colon cancer prognosis

Wei Yang et al.

Summary: This study constructed a prognostic model for colorectal cancer based on necroptosis-related genes. The model accurately predicted the survival rate of colorectal cancer patients and identified relevant biological processes, pathways, and potential therapeutic targets.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Revisiting the Warburg Effect with Focus on Lactate

Eva Kocianova et al.

Summary: This review discusses the role and significance of lactate in cancer, as well as recent findings on lactate metabolism and signaling pathways in cancer.

CANCERS (2022)

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Review Biochemistry & Molecular Biology

SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer

Jaewang Lee et al.

Summary: SLC7A11 is a cell transmembrane protein that plays a critical role in maintaining redox homeostasis and has implications in cancer development and treatment. Further understanding of its functions could lead to novel cancer therapeutics.

ANTIOXIDANTS (2022)

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Article Biotechnology & Applied Microbiology

SLC6A14 Depletion Contributes to Amino Acid Starvation to Suppress EMT-Induced Metastasis in Gastric Cancer by Perturbing the PI3K/AKT/mTORC1 Pathway

Qie Guo et al.

Summary: Metastasis is a major challenge in the treatment of gastric cancer. The SLC6A14 gene plays a crucial role in the migration and invasion of gastric cancer cells, and targeting SLC6A14 shows promise for the treatment of metastatic gastric cancer.

BIOMED RESEARCH INTERNATIONAL (2022)

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Article Cell Biology

Up-regulation of SLC27A2 suppresses the proliferation and invasion of renal cancer by down-regulating CDK3-mediated EMT

Ning Xu et al.

Summary: SLC27A2 downregulation is associated with poor prognosis in clear cell renal cell carcinoma (ccRCC). Upregulation of SLC27A2 inhibits proliferation, migration, and invasion of renal cancer cell lines, and affects the progression and metastasis of ccRCC.

CELL DEATH DISCOVERY (2022)

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Article Oncology

Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

Federica Cappellesso et al.

Summary: SLC4A4 inhibition in pancreatic ductal adenocarcinoma (PDAC) improves the acidic tumor microenvironment, enhances T cell-mediated immune response, and suppresses tumor growth and metastasis.

NATURE CANCER (2022)

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Letter Medicine, Research & Experimental

Genome-wide methylation profiling reveals differentially methylated genes in blood DNA of small-cell lung cancer patients

Yanqi He et al.

PRECISION CLINICAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

A guide to plasma membrane solute carrier proteins

Mattia D. Pizzagalli et al.

Summary: This review provides an overview of the SLC superfamily of transporter proteins and their roles in regulating metabolism and environmental conditions at the cell surface, with a focus on their involvement in cancer development and progression.

FEBS JOURNAL (2021)

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Review Medicine, General & Internal

Deciphering the role of epigenetic modifications in fatty liver disease: A systematic review

Xiaofang Zhang et al.

Summary: Fatty liver disease, particularly nonalcoholic fatty liver disease, is associated with epigenetic modifications, such as DNA methylation and miRNAs. Some studies suggest that certain miRNAs may serve as biomarkers for FLD. Further research is needed to explore how these epigenetic markers regulate FLD and the potential role of histone modifications in FLD.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Biotechnology & Applied Microbiology

Aberrant SLC6A14 Expression Promotes Proliferation and Metastasis of Colorectal Cancer via Enhancing the JAK2/STAT3 Pathway

Hongli Mao et al.

Summary: The study revealed that high levels of SLC6A14 expression in colorectal cancer patients were associated with advanced tumor stage, lymph node metastasis, and poor prognosis. SLC6A14 promoted cell proliferation, inhibited apoptosis, and enhanced cell migration and invasion in CRC through activation of the JAK2/STAT3 signaling pathway. These findings suggest that targeting the SLC6A14/JAK2/STAT3 axis may be a potential therapeutic strategy for CRC patients.

ONCOTARGETS AND THERAPY (2021)

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Article Medicine, General & Internal

SLC12A8 plays a key role in bladder cancer progression and EMT

Shun-Lai Li et al.

Summary: This study investigated the prognostic value and biological function of SLC12A8 in bladder cancer, revealing its close correlation with the oncogenesis and progression of bladder cancer, making it a potential biomarker for early diagnosis and treatment of the disease.

OPEN MEDICINE (2021)

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Article Multidisciplinary Sciences

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

McLane J. Watson et al.

Summary: T-reg cells exhibit broad heterogeneity in glucose metabolism within normal and transformed tissues, utilizing an alternative metabolic pathway to maintain their suppressive function and proliferation. Glucose uptake is correlated with poorer suppressive function and long-term instability, while high-glucose conditions impair T-reg cell function and stability. Additionally, T-reg cells upregulate pathways involved in the metabolism of lactic acid, with lactate uptake being dispensable for peripheral T-reg cells but required intratumorally for slowed tumor growth and increased response to immunotherapy.

NATURE (2021)

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Article Oncology

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

George Sharbeen et al.

Summary: High expression of SLC7A11 in human PDAC tumor stroma, independently prognostic of poorer overall survival. The study demonstrates that PDAC-derived CAFs are highly dependent on SLC7A11 for cystine uptake and glutathione synthesis. Inhibition of SLC7A11 decreases CAF proliferation, reduces their resistance to oxidative stress, and inhibits their ability to support PDAC cell growth.

CANCER RESEARCH (2021)

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Review Pharmacology & Pharmacy

Solute carriers as potential oncodrivers or suppressors: their key functions in malignant tumor formation

Khalid Rashid et al.

Summary: Solute carrier (SLC) transporters play diverse roles in tumor modulation, not only through influx/efflux mechanisms but also by activating signaling network cascades that drive metastatic tumor formation. However, further research is needed to fully understand the implications of these proteins in cancer pathogenesis.

DRUG DISCOVERY TODAY (2021)

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Article Oncology

Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor

Junryo Rii et al.

Summary: LAT3 is abundantly expressed in prostate cancer cells and plays a crucial role in cancer progression by affecting cell proliferation, migration, and invasion. Its high expression is associated with poor prognosis and advanced disease stage in prostate cancer.

CANCER SCIENCE (2021)

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Review Genetics & Heredity

Navigating the DNA methylation landscape of cancer

Atsuya Nishiyama et al.

Summary: DNA methylation is a chemical modification that defines cell type and lineage through controlling gene expression and genome stability. Aberrant DNA methylation in cancer cells targets CpG islands in gene expression regulatory elements. Recent studies suggest that the classical model of DNA hypermethylation in cancer needs to be reevaluated.

TRENDS IN GENETICS (2021)

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Review Oncology

Contemporary Perspectives on the Warburg Effect Inhibition in Cancer Therapy

Karolina Kozal et al.

Summary: This review summarizes the current state of knowledge regarding inhibitors of cancer glucose metabolism and their clinical potential. Research shows that the altered metabolic phenotype of cancer cells enables them to grow and proliferate while surviving in hypoxic conditions. Targeting energy metabolism of cancer cells for therapy might improve conventional anti-cancer methods.

CANCER CONTROL (2021)

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Article Biotechnology & Applied Microbiology

Solute carrier family 12 member 8 (SLC12A8) is a potential biomarker and related to tumor immune cell infiltration in bladder cancer

Qian Zhang et al.

Summary: The study found that SLC12A8 is significantly overexpressed in bladder cancer tissues, leading to a shorter overall survival time and serving as an unfavorable prognostic biomarker. Additionally, SLC12A8 is associated with tumor-infiltrating immune cells and crucial immune checkpoint molecules in bladder cancer.

BIOENGINEERED (2021)

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Article Chemistry, Multidisciplinary

Optoproteomics elucidates the interactome of L-type amino acid transporter 3 (LAT3)

Liquan Wang et al.

Summary: The study applied genetic code expansion in combination with photo-crosslinking chemistry, termed optoproteomics, to identify proteins interacting with the human L-type membrane amino acid transporter 3 (LAT3). The site-specifically incorporated photo-cross-linker AzF enabled the capture of weak and transient partners of LAT3 in living cells, revealing insights into the LAT3 protein-protein interaction network currently unavailable.

CHEMICAL COMMUNICATIONS (2021)

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Article Biotechnology & Applied Microbiology

Solute carrier family 12 member 8 impacts the biological behaviors of breast carcinoma cells by activating TLR/NLR signaling pathway

LinWei Li et al.

Summary: The study showed that SLC12A8 is upregulated in breast carcinoma, with high levels associated with a poorer prognosis and a positive correlation with the TLR/NLR signaling pathway. Functional experiments revealed that SLC12A8 promotes cell viability, invasiveness, and motility in breast carcinoma cells by activating the TLR/NLR signaling pathway.

CYTOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Identification of Genes Related to Clinicopathological Characteristics and Prognosis of Patients with Colorectal Cancer

Xueren Gao et al.

DNA AND CELL BIOLOGY (2020)

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Article Pharmacology & Pharmacy

Endocytosis of ATB0,+(SLC6A14)-targeted liposomes for drug delivery and its therapeutic application for pancreatic cancer

Longfa Kou et al.

EXPERT OPINION ON DRUG DELIVERY (2020)

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Article Biochemistry & Molecular Biology

SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms

Jing He et al.

ONCOGENE (2020)

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Review Pharmacology & Pharmacy

Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease

Melanie A. Felmlee et al.

PHARMACOLOGICAL REVIEWS (2020)

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Article Multidisciplinary Sciences

Analysis of DNA methylation associates the cystine-glutamate antiporter SLC7A11 with risk of Parkinson's disease

Costanza L. Vallerga et al.

NATURE COMMUNICATIONS (2020)

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Article Cell Biology

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Xiaoguang Liu et al.

NATURE CELL BIOLOGY (2020)

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Review Oncology

Uptake Transporters of the SLC21, SLC22A, and SLC15A Families in Anticancer Therapy-Modulators of Cellular Entry or Pharmacokinetics?

Karin Brecht et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy

Weimin Wang et al.

MOLECULAR CELL (2020)

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Review Endocrinology & Metabolism

Shaping of Dendritic Cell Function by the Metabolic Micro-Environment

Eline Constance Brombacher et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Review Pharmacology & Pharmacy

FATP2-targeted therapies - A role beyond fatty liver disease

Peishan Qiu et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Cell Biology

Intracellular Transport in Cancer Metabolic Reprogramming

Marte Sneeggen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Oncology

Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil

Larissa B. Reis et al.

BMC CANCER (2020)

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Article Medicine, Research & Experimental

Prognostic Value of SLC4A4 and its Correlation with Immune Infiltration in Colon Adenocarcinoma

Xiaoli Chen et al.

MEDICAL SCIENCE MONITOR (2020)

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Article Oncology

Down-regulated Solute Carrier Family 4 Member 4 Predicts Poor Progression in Colorectal Cancer

Hong Yang et al.

JOURNAL OF CANCER (2020)

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Article Oncology

Cellular localization of the K+-dependent Na+-Ca2+ exchanger NCKX5 and the role of the cytoplasmic loop in its distribution in pigmented cells

Tatiana P. Rogasevskaia et al.

PIGMENT CELL & MELANOMA RESEARCH (2019)

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Article Oncology

LOX and ACSL5 as potential relapse markers for pancreatic cancer patients

Weidong Ma et al.

CANCER BIOLOGY & THERAPY (2019)

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Article Oncology

A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer

Deaglan McHugh et al.

INVESTIGATIONAL NEW DRUGS (2019)

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Article Immunology

Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

Liangliang Ji et al.

IMMUNITY (2019)

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Review Cell Biology

The diverse roles of DNA methylation in mammalian development and disease

Maxim V. C. Greenberg et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Article Cell Biology

T Cell Activation Depends on Extracellular Alanine

Noga Ron-Harel et al.

CELL REPORTS (2019)

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Review Genetics & Heredity

The Impact of One Carbon Metabolism on Histone Methylation

Magdalini Serefidou et al.

FRONTIERS IN GENETICS (2019)

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Review Cell Biology

The SLC transporter in nutrient and metabolic sensing, regulation, and drug development

Yong Zhang et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2019)

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Review Immunology

Metabolic interventions in the immune response to cancer

David O'Sullivan et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Endocrinology & Metabolism

Slc12a8 is a nicotinamide mononucleotide transporter

Alessia Grozio et al.

NATURE METABOLISM (2019)

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Article Oncology

The Expression of Riboflavin Transporters in Human Colorectal Cancer

Valeria Tutino et al.

ANTICANCER RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

Pierre-Benoit Ancey et al.

FEBS JOURNAL (2018)

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Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

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Article Biochemistry & Molecular Biology

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

Xiangming Ji et al.

ONCOGENE (2018)

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Article Multidisciplinary Sciences

CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1

Kevin W. Huynh et al.

NATURE COMMUNICATIONS (2018)

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Article Medicine, Research & Experimental

Genome-wide methylation analysis identifies novel prognostic methylation markers in colon adenocarcinoma

Weinan Xue et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Pharmacology & Pharmacy

In silico Prioritization of Transporter-Drug Relationships From Drug Sensitivity Screens

Adrian Cesar-Razquin et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Food Science & Technology

Riboflavin and health: A review of recent human research

Kiran Thakur et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

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Article Gastroenterology & Hepatology

Epigenome-Wide Association Study Identifies Methylation Sites Associated With Liver Enzymes and Hepatic Steatosis

Jana Nano et al.

GASTROENTEROLOGY (2017)

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Article Cell Biology

Overexpression of SLC34A2 is an independent prognostic indicator in bladder cancer and its depletion suppresses tumor growth via decreasing c-Myc expression and transcriptional activity

Wen Ye et al.

CELL DEATH & DISEASE (2017)

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Review Pharmacology & Pharmacy

Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition

Fanfan Zhou et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

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Review Biochemistry & Molecular Biology

SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms

Yangzom D. Bhutia et al.

BIOCHEMICAL JOURNAL (2016)

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Article Oncology

The Discovery and Preclinical Development of ASG-5ME, an Antibody-Drug Conjugate Targeting SLC44A4-Positive Epithelial Tumors Including Pancreatic and Prostate Cancer

Michael Mattie et al.

MOLECULAR CANCER THERAPEUTICS (2016)

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Article Biochemistry & Molecular Biology

Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer

Ellappan Babu et al.

BIOCHEMICAL JOURNAL (2015)

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Article Cell Biology

The effects and mechanisms of SLC34A2 in tumorigenesis and progression of human non-small cell lung cancer

Yu Wang et al.

JOURNAL OF BIOMEDICAL SCIENCE (2015)

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Article Biochemistry & Molecular Biology

DNA methylation reprogramming in cancer: Does it act by re-configuring the binding landscape of Polycomb repressive complexes?

James P. Reddington et al.

BIOESSAYS (2014)

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Article Biochemistry & Molecular Biology

Molecular Identification and Functional Characterization of the Human Colonic Thiamine Pyrophosphate Transporter

Svetlana M. Nabokina et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Review Physiology

The SLC34 family of sodium-dependent phosphate transporters

Carsten A. Wagner et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2014)

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Review Pharmacology & Pharmacy

The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy

Yangzom D. Bhutia et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

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Article Biochemistry & Molecular Biology

Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis

Pingfang Song et al.

JOURNAL OF NEUROCHEMISTRY (2013)

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Review Biochemistry & Molecular Biology

Novel riboflavin transporter family RFVT/SLC52: Identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52

Atsushi Yonezawa et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

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Article Biochemistry & Molecular Biology

Association of the plasma riboflavin levels and riboflavin transporter (C20orf54) gene statuses in Kazak esophageal squamous cell carcinoma patients

Julaiti Ainiwaer et al.

MOLECULAR BIOLOGY REPORTS (2013)

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Review Oncology

Serine, glycine and one-carbon units: cancer metabolism in full circle

Jason W. Locasale

NATURE REVIEWS CANCER (2013)

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Review Pharmacology & Pharmacy

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

Megan Roth et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Article Biochemistry & Molecular Biology

Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma

Christopher J. Ricketts et al.

EPIGENETICS (2012)

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Article Multidisciplinary Sciences

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

Pierre Sonveaux et al.

PLOS ONE (2012)

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Article Biotechnology & Applied Microbiology

Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel

Uchenna O. Njiaju et al.

PHARMACOGENETICS AND GENOMICS (2012)

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Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

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Article Endocrinology & Metabolism

FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase

Alaric Falcon et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)

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Article Immunology

The Cystine/Glutamate Antiporter Regulates Dendritic Cell Differentiation and Antigen Presentation

June A. D'Angelo et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Multidisciplinary Sciences

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Ralph J. DeBerardinis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Hematology

Inhibitory effect of tumor cell-derived lactic acid on human T cells

Karin Fischer et al.

BLOOD (2007)

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Review Oncology

Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells

Ying Huang et al.

CANCER LETTERS (2006)

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Article Oncology

Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix

N Gupta et al.

GYNECOLOGIC ONCOLOGY (2006)

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Review Oncology

Multidrug resistance in cancer: Role of ATP-dependent transporters

MM Gottesman et al.

NATURE REVIEWS CANCER (2002)

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In silico analysis of the solute carrier (SLC) family in cancer indicates a link among DNA methylation, metabolic adaptation, drug response, and immune reactivity

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