期刊
FRONTIERS IN PHARMACOLOGY
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2023.1081334
关键词
non-alcoholic fatty liver diseases; non-alcoholic steatohepatitis; inflammation; peroxisome proliferator-activated receptor- gamma (PPAR-gamma); insulin resistance
Non-alcoholic fatty liver disease (NAFLD) is a common chronic metabolic liver disorder characterized by fat accumulation in the liver. Inflammation is a significant mechanism that can lead to cell death and tissue injury in NAFLD. Inhibition of inflammation improves NAFLD by reducing fat content, inducing hepato-protective autophagy, overexpressing peroxisome proliferator-activated receptor- gamma (PPAR-gamma), and increasing insulin sensitivity. Understanding the molecular mechanisms and signaling pathways in NAFLD is crucial for its prevention and treatment.
Non-alcoholic fatty liver disease (NAFLD) is common chronic metabolic liver disorder which is associated with fat accumulation in the liver. It causes a wide range of pathological effects such as insulin resistance, obesity, hypertension, diabetes, non-alcoholic steatohepatitis (NASH) and cirrhosis, cardiovascular diseases. The molecular mechanisms that cause the initiation and progression of NAFLD remain fully unclear. Inflammation is regarded as a significant mechanism which could result in cell death and tissue injury. Accumulation of leukocytes and hepatic inflammation are important contributors in NAFLD. Excessive inflammatory response can deteriorate the tissue injury in NAFLD. Thus, inhibition of inflammation improves NAFLD by reducing intrahepatic fat content, increasing beta-oxidation of fatty acids, inducing hepato-protective autophagy, overexpressing peroxisome proliferator-activated receptor- gamma (PPAR-gamma), as well as attenuating hepatocyte apoptosis and increasing insulin sensitivity. Therefore, understanding the molecules and signaling pathways suggests us valuable information about NAFLD progression. This review aimed to evaluate the inflammation in NAFLD and the molecular mechanism on NAFLD.
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