☆ 4.7 Article

Stylopine: A potential natural metabolite to activate vascular endothelial growth factor receptor 2 (VEGFR2) in osteosarcoma therapy

FRONTIERS IN PHARMACOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Ligand-Based Virtual Screening and Molecular Docking of Benzimidazoles as Potential Inhibitors of Triosephosphate Isomerase Identified New Trypanocidal Agents

Lenci K. Vazquez-Jimenez et al.

Summary: In this study, a ligand-based virtual screening was performed to identify potential TcTIM inhibitors. Molecular docking and molecular dynamics simulation analysis showed a favorable docking score of the BP5 compound on TcTIM, and a lower docking score on human TIM compared to the control ligand. Both BP2 and BP5 compounds exhibited good physicochemical and pharmacokinetic properties as new anti-T. cruzi agents.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Oncology

Osteosarcoma

Bree R. Eaton et al.

Summary: Osteosarcoma requires complex multidisciplinary management, with standard treatment involving chemotherapy and surgical resection, and radiotherapy used primarily for cases that cannot be surgically removed or for cases of incomplete resection.

PEDIATRIC BLOOD & CANCER (2021)

添加到收藏夹

Article Environmental Sciences

Onosma bracteata Wall. induces G0/G1 arrest and apoptosis in MG-63 human osteosarcoma cells via ROS generation and AKT/GSK3β/cyclin E pathway

Ajay Kumar et al.

Summary: The study found that the Obea fraction extracted from O. bracteata exhibits strong antioxidant properties and cytotoxicity, showing significant antiproliferative activity against human osteosarcoma MG-63, human neuroblastoma IMR-32, and human lung cancer A549 cell lines. Antioxidant and cytotoxic potential were attributed to the presence of catechin, kaempferol, onosmin A, and epicatechin in the Obea fraction.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis

Mahshid Ghasemi et al.

Summary: The MTT assay is commonly used in studies of cell toxicity, but it is often misinterpreted. Our research found that the assay measurements are influenced by various factors and require optimization and rational interpretation of the data to avoid misleading conclusions. While the assay can be a powerful tool, it also has limitations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Engineering, Biomedical

Osteosarcoma: a review of current and future therapeutic approaches

Xin Zhao et al.

Summary: Osteosarcoma is a common primary bone malignancy that poses a serious threat to human health globally, characterized by high malignancy and rapid progression. The incidence of osteosarcoma has a bimodal distribution pattern with peaks in different age groups, mainly presenting as single lesions. This article summarizes the types, clinical diagnosis, and treatment methods of osteosarcoma.

BIOMEDICAL ENGINEERING ONLINE (2021)

添加到收藏夹

Article Materials Science, Biomaterials

Development of on-demand thermo-responsive hydrogels for anti-cancer drugs sustained release: Rational design, in silico prediction and in vitro validation in colon cancer models

Gustavo Carreno et al.

Summary: A rational design approach based on Statistical Design of the Experiments (DoE) and Molecular Dynamics Simulations Studies allows the prediction and understanding of thermo-responsive hydrogels, leading to the development of ideal hydrogel formulations for local sustained release of anticancer drugs. The formulation composed of NIPAM and 4-penten-1-ol crosslinked with poly(ethylene glycol) diacrylate (PEGDA) (PNiPenPH) presents a slow release of anticancer drug, demonstrating ideal properties for local sustained drug release applications.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Virtual Screening for Potential Phytobioactives as Therapeutic Leads to Inhibit NQO1 for Selective Anticancer Therapy

Bhargav Shreevatsa et al.

Summary: NQO1 is a multifunctional antioxidant enzyme with both tumor suppression and promotion properties. In this study, the flavone compound Orientin demonstrated a better binding affinity and favorable ADME properties compared to the standard inhibitor Dicumarol in targeting NQO1. Computational simulations showed that Orientin induces a potential conformational change in the substrate-binding site of NQO1, inhibiting substrate accessibility towards the FAD-binding domain. Our findings offer a promising direction for the development of new therapeutic components targeting NQO1.

MOLECULES (2021)

添加到收藏夹

Review Oncology

Stimuli-Responsive Hydrogels for Cancer Treatment: The Role of pH, Light, Ionic Strength and Magnetic Field

Fernanda Andrade et al.

Summary: Cancer remains the second leading cause of death globally, with the major obstacles in treatment being chemotherapy side effects and drug resistance. Research is ongoing to develop new formulations for localized drug delivery at tumor sites to improve treatment outcomes. Stimuli-responsive hydrogels, such as pH-, light-, ionic strength-, and magnetic-responsive hydrogels, show promising results in the localized control and treatment of cancer.

CANCERS (2021)

添加到收藏夹

Review Oncology

Update on Osteosarcoma

Rebekah Belayneh et al.

Summary: In recent years, new surgical techniques and novel forms of chemotherapy are being explored to improve the treatment outcomes of osteosarcoma. Researchers are focusing on precision surgery, inhaled chemotherapy, and novel immunomodulators to block molecular pathways associated with OSA proliferation and metastasis. The goal is to exceed the current plateau in treatment efficacy and improve overall survival rates in the near future.

CURRENT ONCOLOGY REPORTS (2021)

添加到收藏夹

Review Cell Biology

Targeting the VEGF Pathway in Osteosarcoma

Tarek Assi et al.

Summary: Osteosarcoma is the most common primary tumor of the bones in young adults, with poor prognosis in relapsed or metastatic cases. However, advancements in targeted therapy, particularly focusing on angiogenesis, have shown promise in enhancing anti-tumor activity in osteosarcoma patients.

CELLS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Thermo-responsive hydrogels for cancer local therapy: Challenges and state-of-art

Diana Rafael et al.

Summary: Despite extensive efforts from the scientific community, advanced cancer remains incurable. However, thermo-responsive hydrogels have shown promise in improving the efficacy of anticancer drugs and reducing adverse effects, leading to advancements in cancer treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Article Chemistry, Medicinal

Computational Designing and Prediction of ADMET Properties of Four Novel Imidazole-based Drug Candidates Inhibiting Heme Oxygenase-1 Causing Cancers

Mijanur Rahman et al.

Summary: The overexpression of HO-1 is implicated in cancer development, and inhibiting HO-1 with imidazole-based drugs is a potential anticancer strategy. In this study, novel HO-1 inhibiting compounds were designed and showed strong binding affinity with HO-1, along with favorable ADMET data for oral availability.

MOLECULAR INFORMATICS (2021)

添加到收藏夹

Review Oncology

Advancing therapy for osteosarcoma

Jonathan Gill et al.

Summary: Osteosarcoma, the most common primary bone cancer in children and young adults, presents challenges in treatment due to its rarity and molecular heterogeneity. Collaborative efforts in biological discoveries, technologies, and therapeutic approaches are expected to advance osteosarcoma treatment and improve patient outcomes. The increasing feasibility of molecular profiling, along with the creation of robust model systems and large tissue banks, has enhanced understanding of osteosarcoma biology.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

添加到收藏夹

Article Biology

Dieckol exerts anticancer activity in human osteosarcoma (MG-63) cells through the inhibition of PI3K/AKT/mTOR signaling pathway

Shouqiang Zhang et al.

Summary: The study investigated the in vitro anticancer effects of dieckol on human osteosarcoma cells, showing that dieckol could effectively inhibit cell viability and promote apoptosis by blocking the PI3K/AKT/mTOR signaling pathway. This suggests that dieckol may be a promising candidate for osteosarcoma management in the future.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

添加到收藏夹

Review Nanoscience & Nanotechnology

Research Progress of Thermosensitive Hydrogel in Tumor Therapeutic

Nian Ma et al.

Summary: Hydrogel as a drug reservoir system has on-demand drug release and deep tissue penetration ability, enhancing tumor treatment. Thermal therapy is effective for tumor therapy due to its minimal invasiveness and high selectivity, showing significant treatment outcomes.

NANOSCALE RESEARCH LETTERS (2021)

添加到收藏夹

Article Chemistry, Medicinal

Computational Designing and Prediction of ADMET Properties of Four Novel Imidazole-based Drug Candidates Inhibiting Heme Oxygenase-1 Causing Cancers

Mijanur Rahman et al.

Summary: Novel HO-1 inhibiting compounds were designed and showed strong binding affinity in molecular docking studies, with potential for oral absorption and moderate bioactivity. These compounds were found to be non-toxic, non-mutagenic, non-tumorigenic, and non-harmful to the reproductive system, with drug-likeness values indicating their potential as drug candidates.

MOLECULAR INFORMATICS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tumor angiogenesis: causes, consequences, challenges and opportunities

Roberta Lugano et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

添加到收藏夹

Review Oncology

Epidemiology and Risk Factors of Osteosarcoma

Leissan R. Sadykova et al.

CANCER INVESTIGATION (2020)

添加到收藏夹

Review Oncology

Molecular Biology of Osteosarcoma

Anna M. Czarnecka et al.

CANCERS (2020)

添加到收藏夹

Article Oncology

VEGFR2 Promotes Metastasis and PD-L2 Expression of Human Osteosarcoma Cells by Activating the STAT3 and RhoA-ROCK-LIMK2 Pathways

Bingxin Zheng et al.

FRONTIERS IN ONCOLOGY (2020)

添加到收藏夹

Article Oncology

Anlotinib, a novel small molecular tyrosine kinase inhibitor, suppresses growth and metastasis via dual blockade of VEGFR2 and MET in osteosarcoma

Gangyang Wang et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

添加到收藏夹

Article Plant Sciences

Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update

Aparna Singh et al.

PHYTOCHEMISTRY REVIEWS (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Injectable Hydrogels for Localized Cancer Therapy

Dao-yang Fan et al.

FRONTIERS IN CHEMISTRY (2019)

添加到收藏夹

Article Oncology

Dual targeting c-met and VEGFR2 in osteoblasts suppresses growth and osteolysis of prostate cancer bone metastasis

Changki Lee et al.

CANCER LETTERS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Liposomal Treatment of Cancer Cells Modulates Uptake Pathway of Polymeric Nanoparticles by Altering Membrane Stiffness

Shengnan Xiang et al.

SMALL (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells

Abdullah Alshehri et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus

Ivette M. Menendez-Perdomo et al.

MOLECULES (2018)

添加到收藏夹

Article Oncology

Surveillance for lung metastasis from giant cell tumor of bone

Mamer Rosario et al.

JOURNAL OF SURGICAL ONCOLOGY (2017)

添加到收藏夹

Article Cell Biology

Apatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma

Kuisheng Liu et al.

CELL DEATH & DISEASE (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

MTT assay to evaluate the cytotoxic potential of a drug

Ashutosh Bahuguna et al.

BANGLADESH JOURNAL OF PHARMACOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

RANK-RANKL signalling in cancer

Nathalie Renema et al.

BIOSCIENCE REPORTS (2016)

添加到收藏夹

Article Oncology

Clinical and prognostic significance of PD-1 and PD-L1 expression in sarcomas

Semra Paydas et al.

MEDICAL ONCOLOGY (2016)

添加到收藏夹

Article Pathology

Analysis of PD-L1, T-cell infiltrate and HLA expression in chondrosarcoma indicates potential for response to immunotherapy specifically in the dedifferentiated subtype

Marie Kostine et al.

MODERN PATHOLOGY (2016)

添加到收藏夹

Article Oncology

ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib

Jiani Liu et al.

ONCOTARGET (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Inhibition of Chondrosarcoma Growth by mTOR Inhibitor in an In Vivo Syngeneic Rat Model

Jennifer Perez et al.

PLOS ONE (2012)

添加到收藏夹

Article Dentistry, Oral Surgery & Medicine

Cytotoxicity of Portland Cement with Different Radiopacifying Agents: A Cell Death Study

Ana Livia Gomes Cornelio et al.

JOURNAL OF ENDODONTICS (2011)

添加到收藏夹

Article Pediatrics

Therapy for Osteosarcoma

Alexander J Chou et al.

PEDIATRIC DRUGS (2008)

添加到收藏夹

Review Cell Biology

Mechanisms of cancer metastasis to the bone

JJ Yin et al.

CELL RESEARCH (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.