Therapeutic potential of artemisinin and its derivatives in managing kidney diseases

Article Biochemistry & Molecular Biology

Artesunate alleviates diabetic retinopathy by activating autophagy via the regulation of AMPK/SIRT1 pathway

Lihua Li et al.

Summary: Artesunate (ART) has therapeutic potential in the treatment of diabetic retinopathy (DR) by inhibiting vascular and inflammatory reactions caused by diabetes, enhancing autophagy, and protecting the retina from damage.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2023)

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Article Chemistry, Multidisciplinary

Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity

Jia-yi He et al.

Summary: Panax notoginseng, a traditional Chinese medicine, has beneficial effects on diabetic kidney disease (DKD) by alleviating podocyte injury through inhibiting apoptosis and mitochondrial damage. Rb1, the main active ingredient of Panax notoginseng, combines with aldose reductase to effectively mitigate the progression of diabetic kidney disease.

ACTA PHARMACOLOGICA SINICA (2022)

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Review Endocrinology & Metabolism

Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria

Irena Audzeyenka et al.

Summary: This review summarizes the current knowledge about podocyte mitochondrial dynamics in diabetic nephropathy, with a focus on bioenergetic pathways. It highlights key studies in this field and potential opportunities to enhance or protect podocyte mitochondrial function in the treatment of diabetic nephropathy.

ENDOCRINOLOGY (2022)

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Article Cell Biology

Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy

Changjiang Ying et al.

Summary: This study confirms that the binding of RAC1 to NLRP3 is sufficient to activate the NLRP3 inflammasome in the kidney and accelerate the development of diabetic nephropathy (DN). The results elucidate the upstream cellular and molecular mechanisms of NLRP3 inflammasome activation and provide new therapeutic strategies for the treatment of DN.

INFLAMMATION RESEARCH (2022)

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Article Biochemistry & Molecular Biology

The Therapeutic Effects of Dihydroartemisinin on Cisplatin-Resistant Gastric Cancer Cells

Suyun Zhang et al.

Summary: Dihydroartemisinin (DHA) has therapeutic effects on cisplatin-resistant gastric cancer cells by enhancing autophagy, inducing apoptosis, and increasing cisplatin sensitivity.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

METTL3-mediated m6A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy

Ling Jiang et al.

Summary: Epigenetic changes, specifically the N-6-methyladenosine (m6A) modification, play a crucial role in diabetic nephropathy (DN). This study demonstrates that METTL3-mediated m6A modification is an important mechanism in podocyte injury in DN. Elevated METTL3 levels lead to increased inflammation and apoptosis, while METTL3 knockout alleviates these responses. Silencing METTL3 shows therapeutic potential in mitigating kidney injury and albuminuria in diabetic mice. METTL3 modulates Notch signaling through m6A modification of TIMP2, exerting pro-inflammatory and pro-apoptotic effects.

MOLECULAR THERAPY (2022)

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Article Chemistry, Physical

Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment

Qingsi Wu et al.

Summary: The etiology of chronic kidney disease is complex, leading to outcomes such as glomerular sclerosis, endothelial dysfunction, and chronic inflammation. Traditional Chinese herb tripterygium wilfordii has shown efficacy in kidney disease treatment, with active ingredient celastrol being toxic. Targeted delivery systems like peptides coupled CLT-phospholipid lipid nanoparticles offer efficient drug delivery to alleviate inflammation and endothelial damage in CKD.

NANO RESEARCH (2022)

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Article Nanoscience & Nanotechnology

Therapeutic effects of cationic liposomes on lupus-prone MRL/lpr mice are mediated via inhibition of TLR4-triggered B-cell activation

Lu Diao et al.

Summary: This study investigated the therapeutic effects of TAT-CLs-DHA/siRNA on lupus-prone MRL/Ipr mice and its impact on B cell responses. The results showed that TAT-CLs-DHA/siRNA suppressed the proliferation and activation of B cells through the TLR4 signaling pathway and significantly reduced lupus-related symptoms in the mice. Furthermore, the study revealed that TAT-CLs-DHA/siRNA modulated the B-cell intrinsic pathway by downregulating expression of certain molecules.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2022)

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Retraction Cell Biology

撤稿声明: SHP-1 aggravates obesity-related glomerulopathy and palmitic acidinduced podocyte injury via regulating the PI3K/Nrf2/SIRT1 axis (Retraction of Vol 323, Pg C650, 2022)

X. Su et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

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Article Pharmacology & Pharmacy

Dihydroartemisinin and artesunate inhibit aerobic glycolysis via suppressing c-Myc signaling in non-small cell lung cancer

Yuxi Zhang et al.

Summary: In this study, it is shown that dihydroartemisinin (DHA) and artemisinin (AS) inhibit aerobic glycolysis in non-small cell lung cancer (NSCLC) cells through the ERK/c-Myc pathway, leading to the inhibition of tumor growth. This study expands our knowledge of artemisinin derivatives in regulating tumor glucose metabolism and provides a potential strategy for lung cancer therapy.

BIOCHEMICAL PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress

Tongxi Li et al.

Summary: This study demonstrates the effectiveness of Dihydroartemisinin (DHA) in reducing inflammation and liver steatosis in Nonalcoholic Steatohepatitis (NASH). DHA achieves this by inhibiting endoplasmic reticulum stress and reducing the production of reactive oxygen species. The study reveals the potential of DHA as a treatment option for NASH.

BIOORGANIC CHEMISTRY (2022)

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Article Chemistry, Medicinal

Hirudin attenuates puromycin aminonucleoside-induced glomerular podocyte injury by inhibiting MAPK-mediated endoplasmic reticulum stress

Chunli Long et al.

Summary: Hirudin protects against podocyte injury and renal pathology by inhibiting p38 MAPK signaling-mediated ER stress.

DRUG DEVELOPMENT RESEARCH (2022)

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Article Endocrinology & Metabolism

Effect of artemisinin on improving islet function in rats fed with maternal high-fat diet

Yu Chen et al.

Summary: The study suggests that intervention with artemisinin in maternal high-fat diet can improve islet function, reduce islet size, decrease the number of beta cells, and enhance islet microcirculation. Additionally, artemisinin restores islet function through increased expression of PC1/3.

GYNECOLOGICAL ENDOCRINOLOGY (2022)

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Article Biochemistry & Molecular Biology

Artesunate restores mitochondrial fusion-fission dynamics and alleviates neuronal injury in Alzheimer's disease models

Yi-Ren Qin et al.

Summary: The study found that artesunate can alleviate neuroinflammation associated with Alzheimer's disease, regulate mitochondrial function, reduce cell apoptosis, and alleviate pathological features in mouse models, potentially becoming a promising therapeutic for Alzheimer's disease.

JOURNAL OF NEUROCHEMISTRY (2022)

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Review Cell Biology

Protective Effect and Possible Mechanisms of Artemisinin and Its Derivatives for Diabetic Nephropathy: A Systematic Review and Meta-Analysis in Animal Models

Haoyue Feng et al.

Summary: This systematic review evaluated the efficacy and potential mechanisms of artemisinins in reducing diabetic renal injury. The results showed that artemisinins may protect against renal injury by reducing proteinuria and improving kidney function indicators such as blood urea nitrogen and serum creatinine. In addition, artemisinins may lower blood glucose levels but can also lead to weight gain.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Plant Sciences

Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy

Xuansheng Ding et al.

Summary: This study found that ICA can inhibit the activation of NLRP3 inflammasome by increasing Sesn2-induced mitophagy, thus exerting a protective effect.

PHYTOMEDICINE (2022)

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Article Neurosciences

Dihydroartemisinin attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting oxidative stress

Qian Xiong et al.

Summary: DHA can alleviate brain damage caused by hypoxic-ischemic encephalopathy by inhibiting oxidative stress and enhancing antioxidant capacity, and improve cognitive and motor function.

MOLECULAR BRAIN (2022)

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Article Biotechnology & Applied Microbiology

Artemether Alleviates Diabetic Kidney Disease by Modulating Amino Acid Metabolism

Guangli Rong et al.

Summary: This study aimed to investigate the role of artemether in regulating renal amino acid metabolism in T1DM and T2DM mice. The results showed that artemether can lower blood glucose, reduce urinary albumin excretion, and attenuate the deterioration of renal function in DKD, possibly through modulating amino acid metabolism.

BIOMED RESEARCH INTERNATIONAL (2022)

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Review Pharmacology & Pharmacy

Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury

Tianwen Yao et al.

Summary: This paper demonstrates that traditional Chinese medicine can serve as promising auxiliary therapeutic methods for the treatment of podocyte injury, and has protective effects.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Oncology

Discovery and repurposing of artemisinin

Qiaoli Shi et al.

Summary: The discovery of artemisinin, inspired by traditional Chinese medicine, has revolutionized the treatment of malaria and has the potential to be used in the treatment of other diseases as well. It has provided guidance for the development of traditional Chinese medicine.

FRONTIERS OF MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling

Xia Zhao et al.

Summary: The abnormal immune response in Alzheimer's disease can be improved by regulating microglial activation and neuroinflammation using Artemisinin.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Plant Sciences

Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway

Di Jin et al.

Summary: The therapeutic effect of Jiedu Tongluo Baoshen formula (JTBF) on diabetic kidney disease (DKD) was investigated in this study. It was found that JTBF can effectively reduce proteinuria and protect kidney function in a rat model of DKD. The mechanism of action involves the enhancement of podocyte autophagy, which helps alleviate podocyte damage.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Chemistry, Multidisciplinary

The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling

Fang-ming Yang et al.

Summary: Research shows that SM934 has therapeutic potential for dry eye disease, as it increases tear secretion, maintains conjunctival goblet cells, reduces corneal damage, and decreases levels of inflammatory mediators. Additionally, SM934 reduces the accumulation of TLR4-expressing macrophages in the conjunctiva and suppresses the expression of inflammasome components.

ACTA PHARMACOLOGICA SINICA (2021)

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Review Urology & Nephrology

The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease

Yu Sun et al.

Summary: Disorder of podocyte lipid metabolism is closely associated with various proteinuric kidney diseases, excessive lipid accumulation can lead to cellular dysfunction, ultimately resulting in cell hypertrophy, detachment, and death. Targeting podocyte lipid metabolism may represent a novel therapeutic strategy for patients with proteinuric kidney disease.

KIDNEY DISEASES (2021)

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Review Pharmacology & Pharmacy

Artemisinin and artemisinin derivatives as anti- fibrotic therapeutics

David Dolivo et al.

Summary: Fibrosis is a pathological reparative process in most organs, and artemisinin compounds demonstrate anti-fibrotic effects which can be used for treating fibrotic diseases.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Cell Biology

Artesunate induces apoptosis, autophagy and ferroptosis in diffuse large B cell lymphoma cells by impairing STAT3 signaling

Yingying Chen et al.

Summary: The study found that artemisinin inhibited proliferation, induced apoptosis, cell cycle arrest, autophagy, and ferroptosis in diffuse large B cell lymphoma cells. Inhibition of autophagy and ferroptosis alleviated increased apoptosis induced by artemisinin. Furthermore, artemisinin acted through inhibition of STAT3 activation, and genetic knockdown of STAT3 enhanced autophagy and ferroptosis induced by artemisinin.

CELLULAR SIGNALLING (2021)

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Article

Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs

Xiaobo Li et al.

Evidence-based Complementary and Alternative Medicine (2021)

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Article Biology

Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets

Zemin Lin et al.

Summary: This study revealed the etiology and therapeutic mechanism of antiphospholipid syndrome nephropathy and for the first time demonstrated the therapeutic potential of SM934 in treating this condition.

SCIENCE CHINA-LIFE SCIENCES (2021)

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Article Multidisciplinary Sciences

Artemether ameliorates kidney injury by restoring redox imbalance and improving mitochondrial function in Adriamycin nephropathy in mice

Pengxun Han et al.

Summary: The study found that artemether can ameliorate kidney injury in Adriamycin-induced nephropathy in mice by reducing urinary protein excretion, recovering podocyte alterations, attenuating pathological changes, and alleviating renal tubular injury. Artemether also improved mitochondrial function by restoring redox imbalance, downregulating TGF-beta 1 mRNA expression, inhibiting tubular proliferation, and suppressing proliferation-related signalling pathways.

SCIENTIFIC REPORTS (2021)

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Article Pharmacology & Pharmacy

Artesunate Provides Neuroprotection against Cerebral Ischemia-Reperfusion Injury via the TLR-4/NF-κB Pathway in Rats

Yanlin Chen et al.

Summary: Artesunate (ART) exhibits neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury, potentially by attenuating inflammation through the Toll-like receptor-4 (TLR-4)/nuclear factor-kappa B (NF-kappa B) pathway. This study demonstrates that ART can decrease brain water content, improve neurological deficits, reduce infarct size, and suppress inflammatory responses in the ischemic cortex following ischemia-reperfusion injury.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2021)

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Article Urology & Nephrology

Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria

Yangyang Zuo et al.

Summary: Research revealed that MMP-10 could induce podocyte injury by degrading ZO-1, thereby promoting proteinuria and chronic diseases.

KIDNEY INTERNATIONAL (2021)

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Article Medicine, Research & Experimental

Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway

Xinying Zhang et al.

Summary: This study found that the progression of diabetic nephropathy is influenced by the polyamine metabolic pool, particularly the decrease in spermine content. High glucose can lead to increased kidney weight, abnormal kidney function, increased urinary albumin excretion, mesangial thickening, and loss or fusion of podocytes.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Article Pharmacology & Pharmacy

The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice

Shaojie Yin et al.

Summary: Artesunate can protect against ulcerative colitis by inhibiting excessive ER stress, which helps to preserve intestinal barrier integrity and reduce inflammation. This protective effect is achieved through modulation of ER stress signaling pathways.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Physiology

The Study of Angptl4-Modulated Podocyte Injury in IgA Nephropathy

Sha Jia et al.

Summary: Differential gene expression related to podocytes and Angptl4 was found between IgA nephropathy patients and healthy controls. Plasma and urine levels of Angptl4 were closely associated with podocyte damage and urine protein, suggesting a potential tool for assessing the severity of IgAN.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Cell Biology

METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1

Zhihui Lu et al.

Summary: This study revealed that METTL14-dependent RNA m6A modification contributes to podocyte injury through posttranscriptional regulation of Sirt1 mRNA, providing a potential approach for the diagnosis and treatment of podocytopathies.

CELL DEATH & DISEASE (2021)

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Article Chemistry, Medicinal

Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension

Xuanxuan Liu et al.

Summary: Artemisinin treatment has beneficial effects on endothelium-dependent vascular relaxation in SHRs, improving hypertension by regulating eNOS activity and NO release. It can also decrease heart rate and basal vascular tension.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Review Pharmacology & Pharmacy

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Guoyi Tang et al.

Summary: Chinese medicine has shown promising clinical benefits in the treatment and management of diabetic nephropathy, with its multi-target function affecting crucial mechanisms such as glucose/lipid metabolism regulation, antioxidation, anti-inflammation, anti-fibrosis, and podocyte protection. Studies have emphasized the clinical efficacy of Chinese medicines and their bioactive components, with a focus on identifying the underlying mechanisms and molecular targets.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Pharmacology & Pharmacy

Sanqi Oral Solution Mitigates Proteinuria in Rat Passive Heymann Nephritis and Blocks Podocyte Apoptosis via Nrf2/HO-1 Pathway

Xiaowan Wang et al.

Summary: Idiopathic membranous nephropathy (IMN) is the most common pathological type in adult nephrotic syndrome, with podocyte apoptosis mediating the development of proteinuria. Sanqi oral solution (SQ), a clinically effective Chinese herbal preparation for IMN, reduces proteinuria by decreasing podocyte apoptosis via the Nrf2/HO-1 pathway.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Artesunate Combined With Metformin Ameliorate on Diabetes-Induced Xerostomia by Mitigating Superior Salivatory Nucleus and Salivary Glands Injury in Type 2 Diabetic Rats via the PI3K/AKT Pathway

Siqin Zhang et al.

Summary: This study demonstrated that artesunate or metformin alone, as well as the combination of the two, can alleviate a range of symptoms in diabetic rats and mitigate hyposalivation by improving damage to the central SSN and salivary glands under hyperglycemic conditions. These treatments regulate the PI3K/Akt pathway to inhibit apoptosis and autophagy, while also preserving parasympathetic innervation to alleviate diabetes-induced hyposalivation.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Endocrinology & Metabolism

Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy

Ming Wu et al.

Summary: Inhibition of the NLRP3 inflammasome can alleviate glomerular damage in diabetic nephropathy, protecting podocytes from injury by suppressing lipid accumulation.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Article Endocrinology & Metabolism

Emodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway

Hong Liu et al.

Summary: Emodin effectively improves renal tissue damage and reduces proteinuria in diabetic nephropathy rats by regulating the AMPK/mTOR-autophagy signaling pathway, suppressing cell apoptosis and enhancing podocyte autophagy.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

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Article Cell Biology

Artesunate relieves acute kidney injury through inhibiting macrophagic Mincle-mediated necroptosis and inflammation to tubular epithelial cell

Xian-Ying Lei et al.

Summary: Artesunate has significant renoprotective and anti-inflammatory effects on acute kidney injury in mice, potentially through inhibition of Mincle-mediated macrophage inflammation to reduce damage and necroptosis in tubular cells.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Urology & Nephrology

Receptor activator of NF-κB mediates podocyte injury in diabetic nephropathy

Guibao Ke et al.

Summary: The expression of Receptor activator of NF-kappa B (RANK) is increased in podocytes of patients with diabetic nephropathy. Mouse models of podocyte-specific RANK depletion and overexpression showed that RANK depletion alleviated the development of kidney diseases, while RANK overexpression aggravated the condition. The findings suggest that RANK mediates the development of diabetic nephropathy by promoting glomerular oxidative stress and proinflammatory cytokine production.

KIDNEY INTERNATIONAL (2021)

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Article Cell Biology

Artesunate Restrains Maturation of Dendritic Cells and Ameliorates Heart Transplantation-Induced Acute Rejection in Mice through the PERK/ATF4/CHOP Signaling Pathway

Yuanyang Chen et al.

Summary: This study demonstrated that ART treatment prolonged the survival time of mice in the HT group, reduced inflammatory cell infiltration in heart tissue, and lowered CD4+CD8+ T cell proportions in spleen and lymph nodes. Additionally, ART treatment inhibited oxidative stress damage in heart tissue and myocardial apoptosis. In cell experiments, ART slowed down BMDC development and maturation by inhibiting endoplasmic reticulum stress-related protein expression.

MEDIATORS OF INFLAMMATION (2021)

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Article Biochemistry & Molecular Biology

Protective Effects of Purple Rice Husk against Diabetic Nephropathy by Modulating PGC-lα/SIRT3/SOD2 Signaling and Maintaining Mitochondrial Redox Equilibrium in Rats

Orawan Wongmekiat et al.

Summary: The study demonstrated that purple rice husk extract has a protective effect against diabetic kidney injury by improving mitochondrial function and reducing oxidative damage. This finding opens up possibilities for developing agricultural waste into useful products for diabetes health.

BIOMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Sirt6-mediated Nrf2/HO-1 activation alleviates angiotensin II-induced DNA DSBs and apoptosis in podocytes

Yanqin Fan et al.

Summary: Recent studies have shown the association between DNA double-strand breaks and chronic kidney disease, and the key role of Sirtuin6 (Sirt6) in protecting against Ang II-induced oxidative DNA damage and podocyte injury through the Sirt6-Nrf2-HO-1 pathway has been demonstrated. This pathway involves inhibiting ROS generation and DNA damage, as well as enhancing Nrf2 and HO-1 gene expressions to provide cell protection against Ang II-induced apoptosis.

FOOD & FUNCTION (2021)

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Article Medicine, General & Internal

Acute kidney injury secondary to severe delayed haemolysis in intravenous artesunate use for severe malaria

Kai Wen Leong et al.

Summary: The use of artemisinin derivatives for malaria treatment is recommended for its rapid parasite clearance and safety, but delayed haemolysis can be a complication that is often overlooked. This can lead to severe acute kidney injury, highlighting the importance of close patient monitoring for timely recognition and management of this phenomenon.

BMJ CASE REPORTS (2021)

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Article Medicine, Research & Experimental

GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPK alpha activity

Jian Lu et al.

Summary: The study showed that GPR43 expression was increased in kidney samples of DN patients, diabetic animal models, and high glucose-stimulated podocytes, with deletion of GPR43 alleviating albuminuria and renal injury in diabetic mice. Antibiotic treatment and fecal microbiota transplantation improved podocyte insulin sensitivity and attenuated glomerular injury in diabetic rats by downregulating GPR43 expression and reducing serum acetate levels.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

Guo-Qing Chen et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Biochemistry & Molecular Biology

Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells

Ljubica Vucicevic et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

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Article Cell Biology

Podocytes maintain high basal levels of autophagy independent of mtor signaling

Tillmann Bork et al.

AUTOPHAGY (2020)

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Article Biochemistry & Molecular Biology

Orientin Protects Podocytes from High Glucose Induced Apoptosis through Mitophagy

Zi-Li Kong et al.

CHEMISTRY & BIODIVERSITY (2020)

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Review Endocrinology & Metabolism

The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells

Irina X. Zhang et al.

ENDOCRINOLOGY (2020)

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Article Oncology

Dopamine 1 receptor activation protects mouse diabetic podocytes injury via regulating the PKA/NOX-5/p38 MAPK axis

Xiaoting Shao et al.

EXPERIMENTAL CELL RESEARCH (2020)

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Article Immunology

Dihydroartemisinin inhibits the proliferation of IgAN mesangial cells through the mTOR signaling pathway

Ming Xia et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Artemisinin Attenuated Atherosclerosis in High-Fat Diet-Fed ApoE-/- Mice by Promoting Macrophage Autophagy Through the AMPK/mTOR/ULK1 Pathway

Qian Cao et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

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Editorial Material Biochemistry & Molecular Biology

Heme-Oxygenase-1

Maria M. Facchinetti

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Article Biotechnology & Applied Microbiology

Psoriasis-Like Inflammation Induced Renal Dysfunction through the TLR/NF-κB Signal Pathway

Fang Ren et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Endocrinology & Metabolism

Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease

Qian Shi et al.

MOLECULAR METABOLISM (2020)

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Review Urology & Nephrology

Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors

Milton Packer

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

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Review Pharmacology & Pharmacy

The Therapeutic Effect of Artemisinin and Its Derivatives in Kidney Disease

Ming Xia et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet

Shichen Pu et al.

MOLECULES (2020)

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Article Endocrinology & Metabolism

Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice

Wei Fu et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

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Review Pharmacology & Pharmacy

Emerging drugs for treatment of focal segmental glomerulosclerosis

Howard Trachtman

EXPERT OPINION ON EMERGING DRUGS (2020)

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Article Biochemistry & Molecular Biology

Curcumin attenuates angiotensin II-induced podocyte injury and apoptosis by inhibiting endoplasmic reticulum stress

Nan Yu et al.

FEBS OPEN BIO (2020)

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Review Urology & Nephrology

Autophagy in diabetic nephropathy: a review

Elias A. T. Koch et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2020)

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Article Urology & Nephrology

Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome

Xiaochen Liu et al.

KIDNEY INTERNATIONAL (2020)

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Article Cell Biology

Artemisinin suppresses myocardial ischemia-reperfusion injury via NLRP3 inflammasome mechanism

Fengyue Wang et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)

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Review Pharmacology & Pharmacy

Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases

Dorothy H. J. Cheong et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Pharmacology & Pharmacy

The birth of artemisinin

Nan Ma et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Article Pharmacology & Pharmacy

Artesunate inhibits atherosclerosis by upregulating vascular smooth muscle cells-derived LPL expression via the KLF2/NRF2/TCF7L2 pathway

Lin-Hao He et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Artemisinin attenuates early renal damage on diabetic nephropathy rats through suppressing TGF-beta 1 regulator and activating the Nrf2 signaling pathway

Haishan Zhang et al.

LIFE SCIENCES (2020)

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