☆ 4.7 Review

Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: A review

FRONTIERS IN PHARMACOLOGY (2023)

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Review Biochemistry & Molecular Biology

EGFR pathway targeting drugs in head and neck cancer in the era of immunotherapy

James J. Kang et al.

Summary: Receptor tyrosine kinases (RTKs) are cell surface receptors that bind growth factor ligands and initiate cellular signaling. Among the 20 classes of RTKs, 7 classes are linked to head and neck cancers (HNCs). The epidermal growth factor receptor (EGFR) is the most studied class of RTK, with overexpression observed in 20% of tumors and a variant III expression seen in 15% of aggressive chemoradiotherapy resistant HNCs. Current treatments include EGFR monoclonal antibodies and inhibitors targeting the EGFR, MAPK, and mTOR pathways, with immunotherapy showing effectiveness in a subset of patients with HNC. Combination therapy of immunotherapy and EGFR monoclonal antibodies is being explored to overcome EGFR resistance.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2023)

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Review Biochemistry & Molecular Biology

Polysaccharides from Chinese materia medica: Perspective towards cancer management

Mengqin Qiang et al.

Summary: Cancer has always been a global concern, and the challenges of treatment and prognosis have troubled humanity. Conventional chemotherapeutics often come with adverse effects and drug resistance, making the search for safe and effective drugs necessary. Natural compounds, particularly polysaccharides from Chinese materia medica, have shown potential in fighting cancer. This review explores the chemical composition, biological activity, absorption, and clinical application of these polysaccharides, as well as their anticancer mechanisms. It also discusses the limitations of current research and future perspectives in utilizing Chinese materia medica polysaccharides for cancer treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Review Oncology

Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Devesh Tewari et al.

Summary: This article emphasizes the role of the PI3K-Akt-mTOR signaling pathway in different cancer conditions and the importance of natural products as potential targets for cancer therapy. Additionally, it summarizes and analyzes various preclinical and clinical studies on bioactive compounds derived from natural products that target the PI3K-Akt-mTOR pathway.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Plant Sciences

Polyphyllin D induces apoptosis and protective autophagy in breast cancer cells through JNK1-Bcl-2 pathway

Jiazhe Liu et al.

Summary: The study found that Polyphyllin D (PD) can induce autophagy in breast cancer cells through activation of the JNK1/Bcl-2 pathway, and increase PD-induced cell apoptosis by inhibiting autophagy, thus achieving anti-tumor effects.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway

Xiaojing Zhang et al.

Summary: TBSE activates the Bax/Bcl2 and caspase-9/caspase-3 cascade to induce apoptosis of human colon cancer cells in a dose-dependent manner, which is closely linked to the inhibition of the PI3K/Akt/mTOR signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

The anti-tumor effect of OP-B on ovarian cancer in vitro and in vivo, and its mechanism: An investigation using network pharmacology-based analysis

Shuang Yuan et al.

Summary: This study explored the potential molecular mechanisms of Ophiopogonin B (OP-B) in treating ovarian cancer (OC) through network pharmacology. In vivo and in vitro experiments confirmed that OP-B can suppress OC cell proliferation, migration, induce apoptosis, and cause cell cycle arrest mainly through the regulation of the STAT3 signaling pathway. The results provide a promising alternative to chemotherapy in ovarian cancer treatment.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Plant Sciences

Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research

Fabiolla Rocha Santos Passos et al.

Summary: This review summarizes preclinical studies on the anti-inflammatory activity of steroidal saponins through the modulation of inflammatory cytokines. The results show that steroidal saponins and sapogenins have anti-inflammatory, antinociceptive, and antioxidant effects, and they mainly modulate inflammatory cytokines through the Nf-Kappa B, TLR4, and MAPKs pathways.

PHYTOMEDICINE (2022)

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Article Oncology

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019

Jonathan M. Kocarnik et al.

Summary: The global burden of cancer is substantial and growing, with differences in burden based on Sociodemographic Index (SDI). The largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles from 2010 to 2019.

JAMA ONCOLOGY (2022)

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Article Cell Biology

Targeting AMPK signaling in ischemic/reperfusion injury: From molecular mechanism to pharmacological interventions

Mahshid Deldar Abad Paskeh et al.

Summary: Ischemia is a pathological process that temporarily interrupts blood supply to an organ, leading to cellular and tissue damage. Ischemia/reperfusion (I/R) injury exacerbates oxidative stress-mediated damage. This article discusses the role of AMP-activated protein kinase (AMPK) in I/R and its signaling pathways and therapeutic applications.

CELLULAR SIGNALLING (2022)

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Article Ophthalmology

Panax notoginseng saponins induce apoptosis in retinoblastoma Y79 cells via the PI3K/AKT signalling pathway

Jingchen Liu et al.

Summary: The study showed that Panax notoginseng saponins (PNS) effectively inhibited the proliferation and promoted the apoptosis of retinoblastoma Y79 cells. The apoptosis-promoting effect of PNS may involve the inhibition of the PI3K/AKT signaling pathway, which subsequently regulates the expression of apoptosis-related genes.

EXPERIMENTAL EYE RESEARCH (2022)

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Review Genetics & Heredity

The Interaction Between Autophagy and JAK/STAT3 Signaling Pathway in Tumors

Jiangyan Xu et al.

Summary: This article reviews the recent advances in autophagy and its interaction with the JAK/STAT3 signaling pathway in the pathogenesis, prevention, diagnosis, and treatment of tumors. The JAK/STAT3 pathway plays a key role in regulating cell proliferation, apoptosis, and vascular neogenesis, while autophagy is a fundamental metabolic mechanism for intracellular degradation. Both pathways may have different roles at various stages of tumor development.

FRONTIERS IN GENETICS (2022)

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Review Pharmacology & Pharmacy

Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions

Akansha Chauhan et al.

Summary: Nuclear factor kappa B (NF-κB) is a crucial regulator of signalome and plays a pivotal role in cell functions and cancer progression. Various phytochemicals have been found to modulate NF-κB signaling pathways, providing new insights for cancer-directed interventions.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2022)

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Review Oncology

The Signaling Pathways Associated With Breast Cancer Bone Metastasis

Xuelian Song et al.

Summary: Breast cancer bone metastasis is a complex process involving multiple signaling pathways. This review explores the interactions between these pathways and the role of surface markers and receptors in breast tumors and bone microenvironment, providing a theoretical foundation for understanding the mechanism of BC bone metastasis and developing targeted therapies.

FRONTIERS IN ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Steroidal saponin components and their cancer cell cytotoxicity from Paris rugosa

Ling-Ling Yu et al.

Summary: In this study, the chemical components and availability of Paris rugosa were investigated for the first time using a new analytical method. Eleven novel compounds and ten known compounds were identified, and their structures were confirmed. Furthermore, the cytotoxicity of three compounds against human cancer cell lines was evaluated.

PHYTOCHEMISTRY (2022)

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Article Oncology

Key signal transduction pathways and crosstalk in cancer: Biological and therapeutic opportunities

Dongliao Fu et al.

Summary: This review summarizes recent studies on key signal transduction pathways altered in cancer cells and highlights their potential as novel therapeutic targets.

TRANSLATIONAL ONCOLOGY (2022)

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Review Food Science & Technology

A review of ultrasound-assisted extraction for plant bioactive compounds: Phenolics, flavonoids, thymols, saponins and proteins

Ida Madiha Yusoff et al.

Summary: Plant bioactive compounds are valuable resources for the development of various products such as food, nutraceuticals, cosmetics, and pharmaceuticals. Ultrasound-assisted extraction has emerged as a promising method for extracting these compounds due to its high efficiency, low solvent and time consumption, and suitability for thermo-sensitive compounds. This paper reviews recent advancements in ultrasound-assisted extraction, with a focus on the extraction of compounds such as phenolics, flavonoids, thymols, saponins, and proteins. The paper discusses the mechanism and advantages of ultrasound-assisted extraction, as well as the optimization of extraction variables and the potential for combining ultrasound technology with other processing techniques to enhance food quality and safety. Overall, ultrasound-assisted extraction is an effective method for recovering bioactive compounds from plant materials and improving food processing.

FOOD RESEARCH INTERNATIONAL (2022)

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Miao Zeng et al.

Summary: This review summarizes the mechanisms of various saponins in relieving cerebral ischemia-reperfusion injury (CIRI) and provides valuable information for researchers to design and develop new drugs using saponins to treat CIRI-related conditions.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Biochemistry & Molecular Biology

The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival

Nora Dieguez-Martinez et al.

Summary: Endometrial cancer is the most common gynecologic cancer in developed countries, and its overall survival rate is poor. This study suggests that inhibiting the ERK5/NF-kB pathway can suppress cell proliferation and survival in endometrial cancer and enhance the efficacy of chemotherapy.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Article Biochemistry & Molecular Biology

In addition to its endosomal escape effect, platycodin D also synergizes with ribosomal inactivation protein to induce apoptosis in hepatoma cells through AKT and MAPK signaling pathways

Jin Lei et al.

Summary: This study demonstrates that certain triterpenoid saponins enhance the anti-tumor therapeutic effect of protein toxins by promoting endosomal escape of the proteins and modulating cholesterol metabolism. Additionally, these saponins synergize with the protein toxins to induce caspase-dependent apoptosis by inhibiting Akt and ERK1/2 signaling pathways and activating JNK and p38 MAPK signaling pathways.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Immunology

Gitogenin suppresses lung cancer progression by inducing apoptosis and autophagy initiation through the activation of AMPK signaling

Ting Liu et al.

Summary: Lung cancer is a major cause of tumor-associated death worldwide. This study investigated the effects of GIT, a saponin derived from Tribulus longipetalus, on lung cancer progression. The results showed that GIT inhibited cell proliferation, induced apoptosis, and affected autophagy in lung cancer cells. Moreover, GIT treatment increased reactive oxygen species production and showed no toxicity in vivo. These findings suggest that GIT may be an effective strategy for lung cancer treatment.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Improving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways

Zhi Zhu et al.

Summary: Oncolytic viruses (OVs) are a new class of multi-modal immunotherapies for cancer, with the key to their effectiveness being the immune response they elicit. However, the clinical effectiveness of OV as a monotherapy is limited, leading researchers to explore combinations with other anti-cancer agents. The signaling pathways in cancer and immune cells offer promising targets for rational cancer therapy design. Small molecule modulators of these pathways have shown potential in enhancing anti-tumor immunity.

MOLECULAR CANCER (2022)

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Review Pharmacology & Pharmacy

A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics

Juhaer Anjum et al.

Summary: Abnormalities in the MAPK signaling pathway contribute to carcinogenesis, while polyphenols can modulate this pathway to inhibit cancer cell growth and metastasis.

PHARMACOLOGICAL RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Phytochemical and biological diversity of triterpenoid saponins from family Sapotaceae: A comprehensive review

Mostafa H. Baky et al.

Summary: This review focuses on the phytochemical and biological diversity of triterpenoid saponins in the Sapotaceae family. It highlights the rich content of protobassic acid, 16-alpha-hydroxyprotobassic acid, bayogenin, and oleanolic acid derivatives in Sapotaceae plants. These saponins have been found to exhibit various pharmacological effects and health benefits, including anti-inflammatory, antiulcer, antimicrobial, cytotoxic, anti-hypercholesterolemic, antioxidant, and immunomodulatory activities. The review aims to provide a comprehensive compilation of research on triterpenoid saponins from the Sapotaceae family and suggest future research perspectives.

PHYTOCHEMISTRY (2022)

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Article Medicine, Research & Experimental

Protodioscin inhibits bladder cancer cell migration and growth, and promotes apoptosis through activating JNK and p38 signaling pathways

Yuan-Ru Chen et al.

Summary: This study found that Protodioscin has inhibitory effects on cell proliferation, migration, invasion, and EMT in bladder cancer cells. Moreover, Protodioscin can induce cell apoptosis and arrest cell cycle progression, and it exerts its anti-cancer effects through regulating the MAPK and PI3K/AKT/mTOR signaling pathways.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Medicine, Research & Experimental

Ginsenosides in cancer: A focus on the regulation of cell metabolism

Wang Yao et al.

Summary: Metabolic alterations play a crucial role in tumor initiation and progression, making them a potential target for cancer treatment. Ginsenosides, as traditional Chinese medicines, have shown antitumor effects in addition to their other benefits. Recent research has focused on how ginsenosides regulate cancer cell metabolism. This review summarizes the structural characteristics, classification, antitumor mechanisms, and recent progress of ginsenoside research in modulating cancer cell metabolism.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Oncology

Current and future burden of breast cancer: Global statistics for 2020 and 2040

Melina Arnold et al.

Summary: Breast cancer is the most commonly diagnosed cancer worldwide, with over 2.3 million new cases and 685,000 deaths in 2020. There is significant geographic variation in incidence rates, with lower rates in some Asian and African countries and higher rates in countries like Australia, New Zealand, Northern America, and parts of Europe. Mortality rates show less variation, but transitioning countries still bear a disproportionate burden of breast cancer deaths. By 2040, the burden of breast cancer is predicted to increase further due to population growth and ageing. Global efforts are needed to address this growing burden, especially in transitioning countries where incidence rates are rising rapidly and mortality rates remain high.

BREAST (2022)

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Review Cell Biology

The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?

Marine Jacquet et al.

Summary: Atg8-family proteins, including GABARAP and LC3, play crucial roles in autophagy and cancer. While downregulation of GABARAPs is associated with cancer progression, the expression of LC3s does not correlate with specific tumor types or stages. The exact role of Atg8-family proteins in cancer remains unclear, but it seems to be related to their involvement in selective protein degradation through autophagy.

AUTOPHAGY (2021)

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Article Biochemistry & Molecular Biology

Natural STAT3 inhibitors: A mini perspective

Zhuo Wang et al.

Summary: This review emphasizes the importance of STAT3 in cancer and as a therapeutic target, and details the development of natural STAT3 inhibitors and the current state of research in this area.

BIOORGANIC CHEMISTRY (2021)

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Review Chemistry, Medicinal

Pyrimidine-based EGFR TK inhibitors in targeted cancer therapy

Adileh Ayati et al.

Summary: Despite advancements in cancer treatment, EGFR inhibitors have shown significant improvement in targeted therapy. However, the emergence of epigenetic mutation and resistance issues have limited their effectiveness, leading to the need for further research in this field. Recent studies have focused on genetic alterations in the EGFR tyrosine kinase domain, resulting in the development of more selective and effective inhibitors.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Plant Sciences

Total saponins from Tupistra chinensis baker inhibits growth of human gastric cancer cells in vitro and in vivo

Zhe Wang et al.

Summary: This study aimed to investigate the potential anti-proliferative activity and anti-tumor mechanism of Tupistra chinensis Baker (TCS) on gastric cancer. The results showed that TCS exhibited significant anti-gastric cancer effects in both in vitro and in vivo experiments.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Plant Sciences

Antiproliferative and antitumour activity of saponins from Astragalus glycyphyllos on myeloid Graffi tumour

Ani Georgieva et al.

Summary: The study evaluated the anti-proliferative/anti-tumour activity of a purified saponins' mixture (PSM) obtained from Astragalus glycyphyllos L. The PSM showed significant decrease in viability/proliferation of Graffi tumour cells, with effects connected to induction of apoptosis. In vivo study demonstrated reduction in tumour weight and pathomorphological changes in hamsters treated with PSM.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration

Sajad Fakhri et al.

Summary: Natural products derived from plants exhibit promising potential in managing and treating various neuronal disorders by targeting the PI3K/Akt/mTOR signaling pathway. Recent studies have highlighted the multi-target nature of these compounds, showcasing their diverse pharmacological and biological activities for combating neurodegenerative diseases effectively. The exploration of plant-derived secondary metabolites in neuroprotection through the PI3K/Akt/mTOR pathway represents an innovative strategy for developing novel therapeutic agents.

PHYTOMEDICINE (2021)

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Article Pharmacology & Pharmacy

KP-10/Gpr54 attenuates rheumatic arthritis through inactivating NF-κB and MAPK signaling in macrophages

Dongsheng Wang et al.

Summary: The upregulation of GPR54 in RA patient tissue is associated with disease severity, while KP-10/GPR54 may have therapeutic effects and can serve as a novel treatment target for RA.

PHARMACOLOGICAL RESEARCH (2021)

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Article Food Science & Technology

Jujuboside B induces mitochondrial-dependent apoptosis in colorectal cancer through ROS-mediated PI3K/Akt pathway in vitro and in vivo

Xiaoling Li et al.

Summary: Jujuboside B (JUB) induces apoptosis of colorectal cancer cells by promoting ROS generation and inactivating the PI3K/Akt signaling pathway, leading to tumor growth inhibition.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Article Plant Sciences

Mechanism of gypenosides of Gynostemma pentaphyllum inducing apoptosis of renal cell carcinoma by PI3K/AKT/mTOR pathway

Hui Liu et al.

Summary: Gypenosides from G. pentaphyllum induced apoptosis of RCC cells by modulating the PI3K/Akt/mTOR signaling pathway. The active compounds and potential targets of G. pentaphyllum in RCC treatment were identified through network pharmacology and in vitro experiments.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Targeting autophagy using saponins as a therapeutic and preventive strategy against human diseases

Bing Han et al.

Summary: Autophagy is a common mechanism for maintaining cellular homeostasis by degrading proteins, protein aggregates, and organelles, and dysfunction of autophagy is observed in many diseases. Saponins, natural compounds with autophagy-modulating effects, may have therapeutic and preventive effects on autophagy-related diseases.

PHARMACOLOGICAL RESEARCH (2021)

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Article Cell Biology

Saikosaponin-A induces apoptosis of cervical cancer through mitochondria- and endoplasmic reticulum stress-dependent pathway in vitro and in vivo: involvement of PI3K/AKT signaling pathway

Jikun Du et al.

Summary: Saikosaponin-A induces apoptosis in cervical cancer cells through both mitochondrial pathway and ER stress pathway, while inhibiting the PI3K/Akt signaling pathway, showing potential as a promising therapeutic agent for cervical cancer patients.

CELL CYCLE (2021)

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Article Pharmacology & Pharmacy

Calunduloside E inhibits HepG2 cell proliferation and migration via p38/JNK-HMGB1 signalling axis

Shengnan Wang et al.

Summary: This study demonstrated that Calenduloside E reduced proliferation and migration of HepG2 cells through the p38/JNK-HMGB1 signaling axis, providing a new perspective on the anti-tumor molecular mechanism of CE in Hepatocellular carcinoma.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)

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Milad Ashrafizadeh et al.

Summary: Lung cancer is a major cause of death worldwide, with various risk factors such as genetics, epigenetics, and environmental factors playing a role in its development. The AMP-activated protein kinase (AMPK) signaling pathway is crucial in lung cancer progression, influencing metastasis, proliferation, and response to treatments like chemotherapy and radiotherapy. AMPK activation can both enhance and suppress lung cancer progression, indicating its complex and dual role in cancer cells.

LIFE SCIENCES (2021)

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Natural deep eutectic solvent enhanced pulse-ultrasonication assisted extraction as a multi-stability protective and efficient green strategy to extract anthocyanin from blueberry pomace

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LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Raddeanin A induced apoptosis of non-small cell lung cancer cells by promoting ROS-mediated STAT3 inactivation

Liang Li et al.

Summary: Raddeanin A inhibits proliferation and induces apoptosis of NSCLC cells by promoting ROS-mediated STAT3 inactivation.

TISSUE & CELL (2021)

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Article Biotechnology & Applied Microbiology

Antitumor Effect of Saikosaponin A on Human Neuroblastoma Cells

Tan Cheng et al.

Summary: The study found that SSA has an inhibitory effect on SK-N-AS cells, and its proapoptotic activity is positively correlated with the Bax/Bcl-2/caspase-9/caspase-7/PARP pathway. SSA also inhibited the invasion and migration of SK-N-AS cells by regulating the angiogenesis-related VEGFR2/Src/Akt pathway and EMT-related protein expression.

BIOMED RESEARCH INTERNATIONAL (2021)

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Ziyuglycoside II inhibits the growth of digestive system cancer cells through multiple mechanisms

Zhong Ying et al.

Summary: The study demonstrated that Ziyuglycoside II (ZYG II) has anti-cancer effects on digestive system cancer cells, inducing cell cycle arrest, oxidative stress, and mitochondrial apoptosis. It also showed synergistic inhibitory effects with chemotherapy on cancer cell growth. Network pharmacology analysis predicted UBC, EGFR, and IKBKG as targets of ZYG II, with EGFR signaling identified as a critical pathway for its anti-cancer effects. Further research is needed to evaluate the anti-cancer activities and underlying mechanisms of ZYG II for the development of novel therapeutic strategies for digestive system cancers.

CHINESE JOURNAL OF NATURAL MEDICINES (2021)

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Article Plant Sciences

Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng

Guangfei Wei et al.

JOURNAL OF GINSENG RESEARCH (2020)

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MicroRNA-301a promotes pancreatic cancer invasion and metastasis through the JAK/STAT3 signaling pathway by targeting SOCS5

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Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway

Li Rong et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Anti-cancer effects of Polyphyllin I: An update in 5 years

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CHEMICO-BIOLOGICAL INTERACTIONS (2020)

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Impact of EGFR-TKI Treatment on the Tumor Immune Microenvironment in EGFR Mutation-Positive Non-Small Cell Lung Cancer

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CLINICAL CANCER RESEARCH (2020)

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Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer

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GENE (2020)

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Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF-κB pathways in A549 human lung cancer cells

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Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

Yanyan Zhu et al.

PHARMACOLOGICAL RESEARCH (2020)

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Oncogenic signaling pathways associated with immune evasion and resistance to immune checkpoint inhibitors in cancer

Yoshie Kobayashi et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Targeting the PI3K/Akt/mTOR pathway in non-small cell lung cancer (NSCLC)

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THORACIC CANCER (2020)

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The p38 Pathway: From Biology to Cancer Therapy

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation

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A steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma

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Jujuboside B promotes the death of acute leukemia cell in a RIPK1/RIPK3/MLKL pathway-dependent manner

Miao-Miao Jia et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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The Fire Within: NF-κB Involvement in Non-Small Cell Lung Cancer

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CANCER RESEARCH (2020)

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The Wnt Signalling Pathway: A Tailored Target in Cancer

Malvina Koni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Therapeutic potential of triterpenoid saponin anemoside B4 from Pulsatilla chinensis

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PHARMACOLOGICAL RESEARCH (2020)

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A review of saponin intervention in metabolic syndrome suggests further study on intestinal microbiota

Zichen Luo et al.

PHARMACOLOGICAL RESEARCH (2020)

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S-allylmercaptocysteine inhibits mucin overexpression and inflammation via MAPKs and PI3K-Akt signaling pathways in acute respiratory distress syndrome

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PHARMACOLOGICAL RESEARCH (2020)

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Targeting the Wnt/β-catenin signaling pathway in cancer

Ya Zhang et al.

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A spirostanol saponin isolated from Tupistra chinensis Baker simultaneously induces apoptosis and autophagy by regulating the JNK pathway in human gastric cancer cells

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STEROIDS (2020)

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Inhibitory effects of Paris saponin I, II, VI and VII on HUVEC cells through regulation of VEGFR2, PI3K/AKT/mTOR, Src/eNOS, PLCγ/ERK/MERK, and JAK2-STAT3 pathways

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Review Chemistry, Medicinal

Mitogen-Activated Protein Kinase Inhibitors and T-Cell-Dependent Immunotherapy in Cancer

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PHARMACEUTICALS (2020)

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Apoptosis and G2/M cell cycle arrest induced by a timosaponin A3 from Anemarrhena asphodeloides Bunge on AsPC-1 pancreatic cancer cells

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PHYTOMEDICINE (2019)

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DT-13 inhibited the proliferation of colorectal cancer via glycolytic metabolism and AMPK/mTOR signaling pathway

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PHYTOMEDICINE (2019)

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Polysaccharides as potential anticancer agents-A review of their progress

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CARBOHYDRATE POLYMERS (2019)

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Korean Red ginseng extract inhibits glioblastoma propagation by blocking the Wnt signaling pathway

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JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Systematic screening and characterization of prototype constituents and metabolites of triterpenoid saponins of Caulopphyllum robustum Maxim using UPLC-LTQ Orbitrap MS after oral administration in rats

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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2019)

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Review Oncology

Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance

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SEMINARS IN CANCER BIOLOGY (2019)

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Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways

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VETERINARY MICROBIOLOGY (2019)

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Review Endocrinology & Metabolism

The MAPK Pathway-Based Drug Therapeutic Targets in Pituitary Adenomas

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FRONTIERS IN ENDOCRINOLOGY (2019)

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Application of Herbal Medicines with Heat-Clearing Property to Anti-Microinflammation in the Treatment of Diabetic Kidney Disease

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Paris saponin VII extracted from trillium tschonoskii suppresses proliferation and induces apoptosis of human colorectal cancer cells

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JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

Recent Advances in Biotransformation of Saponins

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MOLECULES (2019)

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Saponins regulate intestinal inflammation in colon cancer and IBD

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PHARMACOLOGICAL RESEARCH (2019)

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Timosaponin AIII, a steroidal saponin, exhibits anti-tumor effect on taxol-resistant cells in vitro and in vivo

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Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells

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Review Chemistry, Medicinal

Natural products as multidrug resistance modulators in cancer

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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NF-κB Signaling in Ovarian Cancer

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CANCERS (2019)

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NF-κB Dependent Chemokine Signaling in Pancreatic Cancer

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Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway

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PHARMACOLOGICAL RESEARCH (2019)

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DT-13 suppresses breast cancer metastasis by modulating PLOD2 in the adipocytes microenvironment

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PHYTOMEDICINE (2019)

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Optimization of saponin extracts using microwave-assisted extraction as a sustainable biopesticide to reduce Pomacea canaliculata population in paddy cultivation

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Panax notoginseng Saponins Ameliorate Leukocyte Adherence and Cerebrovascular Endothelial Barrier Breakdown upon Ischemia-Reperfusion in Mice

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JOURNAL OF VASCULAR RESEARCH (2019)

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Review Oncology

Role of chemotherapy and targeted therapy in early-stage non-small cell lung cancer

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EXPERT REVIEW OF ANTICANCER THERAPY (2018)

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Lycium barbarum polysaccharide protects against oxygen glucose deprivation/reoxygenation-induced apoptosis and autophagic cell death via the PI3K/Akt/mTOR signaling pathway in primary cultured hippocampal neurons

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Pharmacology & Pharmacy

Ginsenoside Rh4 induces apoptosis and autophagic cell death through activation of the ROS/JNK/p53 pathway in colorectal cancer cells

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BIOCHEMICAL PHARMACOLOGY (2018)

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Article Medicine, Research & Experimental

Astragaloside IV inhibits cell migration and viability of hepatocellular carcinoma cells via suppressing long noncoding RNA ATB

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BIOMEDICINE & PHARMACOTHERAPY (2018)

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α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells

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BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Cell Biology

Protodioscin Induces Apoptosis Through ROS-Mediated Endoplasmic Reticulum Stress via the JNK/p38 Activation Pathways in Human Cervical Cancer Cells

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CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Review Oncology

Elaborating the Role of Natural Products on the Regulation of Autophagy and their Potentials in Breast Cancer Therapy

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CURRENT CANCER DRUG TARGETS (2018)

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Molecular mechanism and inhibitory targets of dioscin in HepG2 cells

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Ultrasound-assisted extraction and bioaccessibility of saponins from edible seeds: quinoa, lentil, fenugreek, soybean and lupin

Joaquin Navarro del Hierro et al.

FOOD RESEARCH INTERNATIONAL (2018)

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Article Oncology

Nuclear factor-kappa B as potential therapeutic target in human colon cancer

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miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a

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JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Review Oncology

Wnt signaling in multiple myeloma: a central player in disease with therapeutic potential

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JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Article Chemistry, Analytical

Metabolic analysis of Panax notoginseng saponins with gut microbiota-mediated biotransformation by HPLC-DAD-Q-TOF-MS/MS

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Article Medicine, Research & Experimental

Raddeanin A inhibits growth and induces apoptosis in human colorectal cancer through downregulating the Wnt/β-catenin and NF-κB signaling pathway

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LIFE SCIENCES (2018)

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Raddeanin A, a natural triterpenoid saponin compound, exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-kappa B signal pathway

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Review Food Science & Technology

The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities

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JOURNAL OF FUNCTIONAL FOODS (2018)

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Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells

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Functional mechanism of Ginsenosides on tumor growth and metastasis

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Effects of saponins of patrinia villosa against invasion and metastasis in colorectal cancer cell through NF-κB signaling pathway and EMT

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Review Cell Biology

Advances in targeting epidermal growth factor receptor signaling pathway in mammary cancer

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CELLULAR SIGNALLING (2018)

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Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling

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The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5

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JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Review Biochemistry & Molecular Biology

Perspectives of Plant Natural Products in Inhibition of Cancer Invasion and Metastasis by Regulating Multiple Signaling Pathways

Md. Shahid Sarwar et al.

CURRENT MEDICINAL CHEMISTRY (2018)

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Afrocyclamin A, a triterpene saponin, induces apoptosis and autophagic cell death via the PI3K/Akt/mTOR pathway in human prostate cancer cells

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PHYTOMEDICINE (2018)

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Review Integrative & Complementary Medicine

Structural characteristics, bioavailability and cardioprotective potential of saponins

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INTEGRATIVE MEDICINE RESEARCH (2018)

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Article Chemistry, Medicinal

Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung cancer cells via p38 MAPK, ERK, and Akt signaling pathways

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Review Chemistry, Medicinal

A brief perspective of drug resistance toward EGFR inhibitors: the crystal structures of EGFRs and their variants

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Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling

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Connexin 43 upregulation by dioscin inhibits melanoma progression via suppressing malignancy and inducing M1 polarization

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The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation

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LUNG CANCER (2017)

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Review Microbiology

The resilience of the intestinal microbiota influences health and disease

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NATURE REVIEWS MICROBIOLOGY (2017)

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Review Oncology

The JAK/STAT3 axis: A comprehensive drug target for solid malignancies

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SEMINARS IN CANCER BIOLOGY (2017)

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A novel synthetic derivative of quercetin, 8-trifluoromethyl-3,5,7,3′,4′-O-pentamethyl-quercetin, inhibits bladder cancer growth by targeting the AMPK/mTOR signaling pathway

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ONCOTARGET (2017)

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Review Biochemistry & Molecular Biology

Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

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CELL AND BIOSCIENCE (2017)

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Netrin-1 Improves Functional Recovery through Autophagy Regulation by Activating the AMPK/mTOR Signaling Pathway in Rats with Spinal Cord Injury

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SCIENTIFIC REPORTS (2017)

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Article Cell Biology

IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro

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Article Medicine, Research & Experimental

Ginsenoside Rg3 enhances the anti- proliferative activity of erlotinib in pancreatic cancer cell lines by downregulation of EGFR/PI3K/Akt signaling pathway

Jin Jiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Article Biochemistry & Molecular Biology

Astragaloside IV inhibits progression of glioma via blocking MAPK/ERK signaling pathway

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Saikosaponin-d suppresses cell growth in renal cell carcinoma through EGFR/p38 signaling pathway

C. Cai et al.

NEOPLASMA (2017)

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Review Biochemistry & Molecular Biology

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Roel Nusse et al.

CELL (2017)

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Review Biochemistry & Molecular Biology

Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies

Hendrik Fuchs et al.

BIOMEDICINES (2017)

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Review Biochemistry & Molecular Biology

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer

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BIOMEDICINES (2017)

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Saponin fraction isolated from Conyza blinii H.Lev. demonstrates strong anti-cancer activity that is due to its NF-κB inhibition

Long Ma et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Medicine, Research & Experimental

Regulation of different components from Ophiopogon japonicus on autophagy in human lung adenocarcinoma A549Cells through PI3K/Akt/mTOR signaling pathway

Juan Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Article Biochemistry & Molecular Biology

Paris saponin-induced autophagy promotes breast cancer cell apoptosis via the Akt/mTOR signaling pathway

Zhan-Zhi Xie et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2017)

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Article Biochemistry & Molecular Biology

Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells

Lili Zhang et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2016)

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Review Oncology

The Wnt signaling pathway in cancer

Yann Duchartre et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2016)

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Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways

Yingzhuan Zhan et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2016)

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Article Pharmacology & Pharmacy

Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion

Lingling Si et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

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Article Biochemistry & Molecular Biology

Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways

Yashi Mi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

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Article Plant Sciences

Screening study on the anti-angiogenic effects of Traditional Chinese Medicine - Part I: Heat-clearing and detoxicating TCM

Xiang Tu et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

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Article Plant Sciences

A platycoside-rich fraction from the root of Platycodon grandiflorum enhances cell death in A549 human lung carcinoma cells via mainly AMPK/mTOR/AKT signal-mediated autophagy induction

Nam-Hui Yim et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

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Article Pharmacology & Pharmacy

Eclalbasaponin II induces autophagic and apoptotic cell death in human ovarian cancer cells

Yoon Jin Cho et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2016)

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Review Biochemistry & Molecular Biology

Saponins from Chinese Medicines as Anticancer Agents

Xiao-Huang Xu et al.

MOLECULES (2016)

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Article Oncology

DT-13 attenuates human lung cancer metastasis via regulating NMIIA activity under hypoxia condition

Xiao-Hui Wei et al.

ONCOLOGY REPORTS (2016)

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Review Pharmacology & Pharmacy

Targeting transcription factor STAT3 for cancer prevention and therapy

Edna Zhi Pei Chai et al.

PHARMACOLOGY & THERAPEUTICS (2016)

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Effect of crocin on aged rat kidney through inhibition of oxidative stress and proinflammatory state

Saeed Samarghandian et al.

PHYTOTHERAPY RESEARCH (2016)

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ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway

Jinqiong Jiang et al.

ONCOTARGETS AND THERAPY (2016)

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Article Multidisciplinary Sciences

Antiproliferative and anti-inflammatory polyhydroxylated spirostanol saponins from Tupistra chinensis

Limin Xiang et al.

SCIENTIFIC REPORTS (2016)

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Article Plant Sciences

Pennogenyl saponins induce cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells

Fang-Yi Long et al.

JOURNAL OF ETHNOPHARMACOLOGY (2015)

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Article Pharmacology & Pharmacy

Saponins from Panax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats

Ting Wang et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2015)

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Review Pharmacology & Pharmacy

JNK signalling in cancer: in need of new, smarter therapeutic targets

Concetta Bubici et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

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Article Pharmacology & Pharmacy

Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line

Ying Wang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

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Review Food Science & Technology

Extraction and quantification of saponins: A review

Choon Yoong Cheok et al.

FOOD RESEARCH INTERNATIONAL (2014)

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Article Immunology

Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway

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IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2014)

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Pulsatilla saponin A, an active molecule from Pulsatilla chinensis, induces cancer cell death and inhibits tumor growth in mouse xenograft models

Qiang Liu et al.

JOURNAL OF SURGICAL RESEARCH (2014)

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Review Chemistry, Medicinal

Anti-Diabetic Potential of Panax Notoginseng Saponins (PNS): A Review

Rosette Uzayisenga et al.

PHYTOTHERAPY RESEARCH (2014)

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Review Biochemistry & Molecular Biology

Molecular activities, biosynthesis and evolution of triterpenoid saponins

Jorg M. Augustin et al.

PHYTOCHEMISTRY (2011)

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Review Chemistry, Medicinal

Chemical study and medical application of saponins as anti-cancer agents

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FITOTERAPIA (2010)

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Article Biochemistry & Molecular Biology

Structure-activity relationships of some hederagenin diglycosides:: Haemolysis, cytotoxicity and apoptosis induction

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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)

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