Effect of semaglutide and empagliflozin on cognitive function and hippocampal phosphoproteomic in obese mice

Article Endocrinology & Metabolism

Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial

Stephanie Kullmann et al.

Summary: SGLT2 inhibitors could be a pharmacological approach to reverse brain insulin resistance and improve overall metabolism in prediabetic individuals.

DIABETES CARE (2022)

添加到收藏夹

Article Behavioral Sciences

Deletion of the voltage-gated calcium channel, CaV1.3, causes deficits in motor performance and associative learning

Marisol Lauffer et al.

Summary: L-type voltage-gated calcium channel Ca(V)1.3 plays an important role in regulating neuronal activity in the brain. It has been linked to impairments in fear conditioning and depressive-like behaviors, as well as genetic variations associated with psychiatric disorders. Knockout of Ca(V)1.3 in mice led to deficits in motor learning and impaired associative learning.

GENES BRAIN AND BEHAVIOR (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Voltage-gated calcium channel nanodomains: molecular composition and function

Maria A. Gandini et al.

Summary: Voltage-gated calcium (Ca-V) channels and their regulation by proteins at the synaptic cleft are crucial for neurotransmission, fine-tuning synaptic response by regulating Ca2+ entry into presynaptic terminals and triggering vesicle fusion. Regulation of Ca-V channel properties and numbers at active zones shapes the timing and strength of synaptic function.

FEBS JOURNAL (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Empagliflozin Improves Cognitive Impairment in Frail Older Adults With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction

Pasquale Mone et al.

Summary: This study demonstrates the significant beneficial effects of the SGLT2 inhibitor empagliflozin on cognitive and physical impairment in frail older adults with diabetes and HFpEF. The results show improvements in cognitive function as well as physical impairment in the empagliflozin group compared to the metformin and insulin groups.

DIABETES CARE (2022)

添加到收藏夹

Article Peripheral Vascular Disease

SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients

Pasquale Mone et al.

Summary: This study investigated the functional role of the SGLT2 inhibitor empagliflozin in frail diabetic and hypertensive older adults. The results showed that empagliflozin improved cognitive function and gait speed, and reduced frailty in these patients. Mechanistically, empagliflozin reduced mitochondrial generation of reactive oxygen species in endothelial cells.

HYPERTENSION (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial

Stephanie Kullmann et al.

Summary: Insulin action in the human brain plays an important role in regulating food intake and whole-body insulin sensitivity. This study found that treatment with empagliflozin for 8 weeks can restore hypothalamic insulin sensitivity in individuals with prediabetes, suggesting that SGLT2 inhibition may be a potential pharmacological approach to reverse brain insulin resistance and improve overall metabolism.

DIABETES CARE (2022)

添加到收藏夹

Article Nursing

Effect of Obesity on Cognitive Impairment in Vascular Dementia Rat Model via BDNF-ERK-CREB Pathway

Yoonju Kim et al.

Summary: The study aimed to evaluate whether obesity exacerbates cognitive impairment in vascular dementia rats, and found that obesity worsens cognitive impairment by inhibiting compensatory increases of the BDNF-ERK-CREB pathway.

BIOLOGICAL RESEARCH FOR NURSING (2021)

添加到收藏夹

Article Physiology

Correlation between ketones and mental fatigue in high fat-induced obese and non-obese rats

Paige Niepoetter et al.

Summary: This study found that exposure to a high-fat diet led to increased body weight, higher blood glucose levels, and lower ketone levels in rats. However, it did not significantly affect locomotor activity. Additionally, higher levels of ketones were associated with better cognitive performance.

PHYSIOLOGICAL REPORTS (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Brain insulin, insulin-like growth factor 1 and glucagon-like peptide 1 signalling in Alzheimer's disease

Sergio T. Ferreira

Summary: The brain's insulin signalling plays a crucial role in neuronal health and cognition, with defective signalling associated with neurological disorders like Alzheimer's disease. Recent studies have shed light on mechanisms of neuronal insulin resistance as a key driver of cognitive impairment in AD. Impaired IGF-1 signalling in AD is also a significant focus of investigation for potential therapeutic approaches.

JOURNAL OF NEUROENDOCRINOLOGY (2021)

添加到收藏夹

Article Clinical Neurology

CACNA1A-associated epilepsy: Electroclinical findings and treatment response on seizures in 18 patients

Marie Le Roux et al.

Summary: CACNA1A pathogenic mutations are associated with various neurological phenotypes, including epilepsy. This study found that patients carrying CACNA1A mutations exhibit severe early onset seizures, accompanied by cerebellar dysfunction and intellectual developmental delay.

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Activation of Glucagon-Like Peptide-1 Receptor Ameliorates Cognitive Decline in Type 2 Diabetes Mellitus Through a Metabolism-Independent Pathway

Qiang Li et al.

Summary: The study showed that liraglutide can improve cognitive function in patients with type 2 diabetes mellitus, independent of its hypoglycemic effect and weight loss. Optimal intervention should target cognitive decline in the early stages of dementia.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

添加到收藏夹

Article Clinical Neurology

Empagliflozin reduces vascular damage and cognitive impairment in a mixed murine model of Alzheimer's disease and type 2 diabetes

Carmen Hierro-Bujalance et al.

ALZHEIMERS RESEARCH & THERAPY (2020)

添加到收藏夹

Review Neurosciences

Presynaptic calcium channels: specialized control of synaptic neurotransmitter release

Annette C. Dolphin et al.

NATURE REVIEWS NEUROSCIENCE (2020)

添加到收藏夹

Review Physiology

RareCACNA1Amutations leading to congenital ataxia

Merce Izquierdo-Serra et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics

Therese S. Salameh et al.

BIOCHEMICAL PHARMACOLOGY (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Cognition, Brain Structure, and Brain Function in Individuals with Obesity and Related Disorders

Hirofumi Tanaka et al.

CURRENT OBESITY REPORTS (2020)

添加到收藏夹

Article Clinical Neurology

Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis

Yan-fang Chang et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2020)

添加到收藏夹

Article Neurosciences

Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease

Liping Zhang et al.

JOURNAL OF PARKINSONS DISEASE (2019)

添加到收藏夹

Article Biochemical Research Methods

Label-free absolute protein quantification with data-independent acquisition

Bing He et al.

JOURNAL OF PROTEOMICS (2019)

添加到收藏夹

Article Neurosciences

The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke

Xiaoyan Yang et al.

NEUROPHARMACOLOGY (2019)

添加到收藏夹

Article Neurosciences

Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli

Alexandra Bunda et al.

MOLECULAR BRAIN (2019)

添加到收藏夹

Article Neurosciences

CaV2.1 α1 Subunit Expression Regulates Presynaptic CaV2.1 Abundance and Synaptic Strength at a Central Synapse

Matthias Lubbert et al.

NEURON (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Semaglutide: First Global Approval

Sohita Dhillon

DRUGS (2018)

添加到收藏夹

Review Neurosciences

Glucagon-like Peptide-1 (GLP-1) and neurotransmitters signaling in epilepsy: An insight review

Prashant Koshal et al.

NEUROPHARMACOLOGY (2018)

添加到收藏夹

Article Neurosciences

Opposite Roles in Short-Term Plasticity for N-Type and P/Q-Type Voltage-Dependent Calcium Channels in GABAergic Neuronal Connections in the Rat Cerebral Cortex

Kiyofumi Yamamoto et al.

JOURNAL OF NEUROSCIENCE (2018)

添加到收藏夹

Article Neurosciences

Lower Affinity of Isradipine for L-Type Ca2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease

Nadine J. Ortner et al.

JOURNAL OF NEUROSCIENCE (2017)

添加到收藏夹

Article Medicine, General & Internal

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults

Majid Ezzati et al.

LANCET (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Reduction of Cav1.3 channels in dorsal hippocampus impairs the development of dentate gyrus newborn neurons and hippocampal-dependent memory tasks

Su-Hyun Kim et al.

PLOS ONE (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Inflammation and gut-brain axis link obesity to cognitive dysfunction: plausible pharmacological interventions

Maite Solas et al.

CURRENT OPINION IN PHARMACOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to long-term potentiation and spatial learning

Evanthia Nanou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons

Evanthia Nanou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

添加到收藏夹

Article Cell Biology

The L-type calcium channel Cav1.3 is required for proper hippocampal neurogenesis and cognitive functions

Julia Marschallinger et al.

CELL CALCIUM (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

CACNA1A haploinsufficiency causes cognitive impairment, autism and epileptic encephalopathy with mild cerebellar symptoms

Lena Damaj et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice

Bowen Lin et al.

CARDIOVASCULAR DIABETOLOGY (2014)

添加到收藏夹

Article Neurosciences

Modulation of CaV2.1 channels by neuronal calcium sensor-1 induces short-term synaptic facilitation

Jin Yan et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2014)

添加到收藏夹

Article Biochemical Research Methods

Integrated proteomic analysis of post-translational modifications by serial enrichment

Philipp Mertins et al.

NATURE METHODS (2013)

添加到收藏夹

Article Neurosciences

Synaptic vesicle capture by CaV2.2 calcium channels

Fiona K. Wong et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2013)

添加到收藏夹

Article Neurosciences

Synaptic Refinement of an Inhibitory Topographic Map in the Auditory Brainstem Requires Functional CaV1.3 Calcium Channels

Jan J. Hirtz et al.

JOURNAL OF NEUROSCIENCE (2012)

添加到收藏夹

Review Biochemical Research Methods

Phosphoprotein analysis: from proteins to proteomes

Frederic Delom et al.

PROTEOME SCIENCE (2006)

添加到收藏夹

Article Behavioral Sciences

NMDA receptors and voltage-dependent calcium channels mediate different aspects of acquisition and retention of a spatial memory task

BL Woodside et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2004)

添加到收藏夹

Article Behavioral Sciences

Calcium channel antagonists enhance retention of passive avoidance and maze learning in mice

D Quartermain et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2001)

添加到收藏夹

Effect of semaglutide and empagliflozin on cognitive function and hippocampal phosphoproteomic in obese mice

相关参考文献

导出引文

分享论文