4.7 Review

Updates on the anticancer potential of garlic organosulfur compounds and their nanoformulations: Plant therapeutics in cancer management

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Summary: Breast cancer is a major cause of cancer-related deaths in women worldwide. The increase in tumor heterogeneity and aggressiveness has made the treatment of breast cancer challenging. High intake of certain Allium vegetables, such as garlic, has been associated with a reduced risk of developing breast cancer. DADS and DATS, compounds found in garlic, have anticancer activity and can interfere with breast cancer cell proliferation and metastasis. This review focuses on multidrug resistance mechanisms in breast cancer and discusses the potential anticancer activities of DADS and DATS, particularly in triple-negative breast cancer.

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Summary: This study reports a method for synthesizing ZnO-reduced graphene oxide nanocomposites (ZnO-RGO NCs) using garlic clove extract, which is a simple, inexpensive, and eco-friendly approach. The ZnO-RGO NCs prepared in this way have enhanced anticancer activity and improved biocompatibility.

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Summary: Garlic is a plant that possesses antimicrobial, antiarthritic, antithrombotic, antitumor, hypoglycemic, and hypolipidemic activities. Its anticancer activity, among others, has been extensively studied. Garlic contains several bioactive molecules that inhibit the development of various cancers and affect multiple signaling pathways involved in cancer cell survival.

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Summary: This study found that while SLIT/ROBO signaling is not affected by DATS treatment, cell cycle arrest likely contributes to the antitumor effect of this phytochemical.

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