期刊
LANCET
卷 388, 期 10039, 页码 86-97出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(15)01121-6
关键词
-
资金
- UK Medical Research Council
- Wellcome Trust
- US National Institute of Mental Health
- European Union
- UK National Institute for Social Care and Health Research
- Janssen Pharmaceutical Companies
- US National Institutes of Health [MH-069853, MH-084018, MH-085226, MH-088753, MH-092443, MH-094268, MH-105660, DA-040127]
- Brain AMP
- Behavior Research Foundation
- Stanley Foundation
- RUSK Foundation
- Maryland Stem Cell Research Funds
- Lundbeck Foundation
- Stanley Medical Research Institute
- European Research Council
- MRC [G0800509] Funding Source: UKRI
- Lundbeck Foundation [R155-2014-1724] Funding Source: researchfish
- Medical Research Council [MR/L010305/1, G0800509] Funding Source: researchfish
Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement of other brain areas and circuits. Disturbances of synaptic function might underlie abnormalities of neuronal connectivity that possibly involves interneurons, but the precise nature, location, and timing of these events are uncertain. At present, treatment mainly consists of antipsychotic drugs combined with psychological therapies, social support, and rehabilitation, but a pressing need for more effective treatments and delivery of services exists. Advances in genomics, epidemiology, and neuroscience have led to great progress in understanding the disorder, and the opportunities for further scientific breakthrough are numerous-but so are the challenges.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据