☆ 4.7 Review

Advances in research on the effectiveness and mechanism of Traditional Chinese Medicine formulas for colitis-associated colorectal cancer

FRONTIERS IN PHARMACOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Butyrate-producing colonic clostridia: picky glycan utilization specialists

Maria Louise Leth et al.

Summary: Butyrate-producing human gut microbiota members are associated with a healthy immune-homeostasis and protection from inflammatory disorders and colorectal cancer. This is due to the production of butyrate, which is produced by prevalent and abundant bacteria in the gut. However, our understanding of the glycan utilization mechanisms and preferences of these bacteria is limited. Recent findings have revealed the strategies used by these bacteria to harvest energy from dietary fibers and human milk oligosaccharides (HMOs). The discovery of a conserved protein apparatus that enables the growth of butyrate producers on HMOs highlights their adaptation to both infant and adult guts.

ESSAYS IN BIOCHEMISTRY (2023)

添加到收藏夹

Article Food Science & Technology

Isolation and characterization of new bacteriophages active against Clostridium tyrobutyricum and their role in preventing the late blowing defect of cheese

Marta Avila et al.

Summary: This study identified and characterized new lytic phages that can effectively control Clostridium tyrobutyricum in cheese. These phages had a high host range and quality lysis, and their addition to cheese production and ripening did not affect cheese quality. The phages delayed the appearance of late blowing symptoms caused by C. tyrobutyricum.

FOOD RESEARCH INTERNATIONAL (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Cell death regulation: A new way for natural products to treat osteoporosis

Zhichao Li et al.

Summary: Osteoporosis is a metabolic bone disease that occurs due to an imbalance in bone homeostasis. Different types of programmed cell death (PCD) have been found to regulate bone metabolism and natural products derived from dietary components and medicinal plants show potential for the prevention and treatment of osteoporosis. This review discusses the common types of PCD in osteoporosis and the role of natural products in targeting PCDs for the treatment of osteoporosis.

PHARMACOLOGICAL RESEARCH (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Impact of Co-Delivery of EGCG and Tuna Oil within a Broccoli Matrix on Human Gut Microbiota, Phenolic Metabolites and Short Chain Fatty Acids In Vitro

Meng Shi et al.

Summary: (-)-Epigallocatechin gallate (EGCG) and tuna oil (TO) were added to broccoli by-products (BBP) and tested in an in vitro fermentation model. The results showed that EGCG inhibited the production of short-chain fatty acids (SCFA), while BBP or TO-BBP treatment increased SCFA production. In addition, the addition of EGCG and TO also altered the composition of the gut microbiota, promoting the growth of certain beneficial bacteria.

MOLECULES (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Multicentre derivation and validation of a colitis-associated colorectal cancer risk prediction web tool

Kit Curtius et al.

Summary: This study identified that patients with large, unresected, multifocal LGD and recent moderate/severe inflammation are at highest risk of developing advanced neoplasia. Personalised risk prediction provided via the Ulcerative Colitis-Cancer Risk Estimator can support treatment decision-making.

GUT (2022)

添加到收藏夹

Review Oncology

Inflammatory bowel disease and carcinogenesis

Hiroko Nagao-Kitamoto et al.

Summary: Colorectal cancer is the third most common cancer worldwide and is closely associated with ulcerative colitis. Patients with ulcerative colitis have 2-3 times higher risk of developing colorectal cancer compared to those without the disease. Chronic inflammation is believed to be a major factor contributing to the development of colorectal cancer. Understanding the mechanisms by which inflammation triggers genetic alterations and disrupts intestinal homeostasis may lead to novel therapeutic strategies for the prevention of colorectal cancer.

CANCER AND METASTASIS REVIEWS (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management

Shailja C. Shah et al.

Summary: Patients with inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Chronic inflammation plays a key role in the development of neoplastic progression, resulting in dysplastic precursor lesions. Colitis-associated CRC shares molecular similarities with sporadic CRC and the microbiome and host immune system may also play a role. However, further research is needed to understand the specific molecular differences and their role in inflammation-associated cancers.

GASTROENTEROLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

A Specific Calprotectin Neo-epitope [CPa9-HNE] in Serum from Inflammatory Bowel Disease Patients Is Associated with Neutrophil Activity and Endoscopic Severity

Joachim Hog Mortensen et al.

Summary: The study developed a novel serum calprotectin enzyme-linked immunosorbent assay for monitoring disease activity in inflammatory bowel disease patients. This method showed strong correlations with endoscopic scores and disease severity.

JOURNAL OF CROHNS & COLITIS (2022)

添加到收藏夹

Article Plant Sciences

San-Wu-Huang-Qin decoction attenuates tumorigenesis and mucosal barrier impairment in the AOM/DSS model by targeting gut microbiome

Yelu Zhou et al.

Summary: In this study, it was demonstrated that San-Wu-Huang-Qin decoction effectively inhibits tumorigenesis and protects the mucosal barrier in colorectal cancer (CRC) at least partially by targeting gut microbiota. This research provides a scientific basis for the clinical usage of San-Wu-Huang-Qin decoction in the intervention and prevention of CRC.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Plant Sciences

YYFZBJS inhibits colorectal tumorigenesis by enhancing Tregs-induced immunosuppression through HIF-1a mediated hypoxia in vivo and in vitro

Yuli Zhang et al.

Summary: The study demonstrates the potential of YYFZBJS in preventing colorectal cancer by regulating the polarization of regulatory T cells and enhancing immune responses in the tumor microenvironment. It also highlights the importance of tumor microenvironment in tumorigenesis.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Plant Sciences

Suppression of colitis-associated colorectal cancer by scutellarin through inhibiting Hedgehog signaling pathway activity

Sha Zeng et al.

Summary: Scutellarin effectively ameliorates colitis-associated colorectal cancer (CAC) by suppressing Hedgehog signaling pathway activity, showing potential clinical application.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Huangqin Tang Interference With Colitis Associated Colorectal Cancer Through Regulation of Epithelial Mesenchymal Transition and Cell Cycle

Xuran Ma et al.

Summary: The study showed that Huangqin Tang can ameliorate the progression of inflammation to colorectal cancer by reducing inflammatory factors and regulating cell cycle and epithelial mesenchymal transition pathways.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Integrative & Complementary Medicine

Sishen Wan Treats Ulcerative Colitis in Rats by Regulating Gut Microbiota and Restoring the Treg/Th17 Balance

Yingyun Wang et al.

Summary: This study aimed to explore the mechanism of Sishen Wan (SSW) in treating ulcerative colitis (UC) by regulating gut microbiota and the content of butyric acid, as well as restoring immune balance. SSW improved the pathological changes of colon tissue in UC rats, attenuated disease activity, and restored immune balance. SSW also altered the gut microbiota composition.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

添加到收藏夹

Article Immunology

Identification of Significant Modules and Targets of Xian-Lian-Jie-Du Decoction Based on the Analysis of Transcriptomics, Proteomics and Single-Cell Transcriptomics in Colorectal Tumor

Cheng-Tao Yu et al.

Summary: This study investigated the mechanism of Xian-Lian-Jie-Du decoction (XLJDD) in treating ulcerative colitis-associated colorectal cancer (UC-CRC). Through transcriptomics, proteomics, and single-cell transcriptomics, the researchers found that XLJDD could effectively suppress colorectal tumor development, modulate the expression of prognostic markers Mfsd2a and Ccdc85c, and reduce infiltration of B cells in the colorectal tumor microenvironment.

JOURNAL OF INFLAMMATION RESEARCH (2022)

添加到收藏夹

Article Plant Sciences

Qingchang Wenzhong Decoction reduce ulcerative colitis in mice by inhibiting Th17 lymphocyte differentiation

Siwei Xia et al.

Summary: This study revealed the components of QCWZD and their potential targets in treating UC. The experiments showed that QCWZD can reduce colonic inflammation and restore the normal proportion of Th17 lymphocytes in UC mice. The findings provide a theoretical basis for the clinical application of QCWZD.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Plant Sciences

Huang Qin Decoction inhibits the initiation of experimental colitis associated carcinogenesis by controlling the PAD4 dependent NETs

Zengfeng Pan et al.

Summary: Huang Qin Decoction inhibits the initiation of colitis associated carcinogenesis by controlling PAD4-dependent neutrophil extracellular traps, providing a mechanistic explanation for its therapeutic effects.

PHYTOMEDICINE (2022)

添加到收藏夹

Review Gastroenterology & Hepatology

The epidemiology of inflammatory bowel disease in Asia and Asian immigrants to Western countries

Satimai Aniwan et al.

Summary: The incidence and prevalence of inflammatory bowel disease (IBD) are rapidly increasing in Asia and among Asian immigrants. This population exhibits unique disease phenotypes in terms of gender predominance and complications.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2022)

添加到收藏夹

Article Cell Biology

Wumei Pill Ameliorates AOM/DSS-Induced Colitis-Associated Colon Cancer through Inhibition of Inflammation and Oxidative Stress by Regulating S-Adenosylhomocysteine Hydrolase- (AHCY-) Mediated Hedgehog Signaling in Mice

Jue Wang et al.

Summary: This study investigated the role of S-Adenosylhomocysteine hydrolase (AHCY) in the anti-colorectal cancer (CRC) effects of Wumei Pill (WMP). The results showed that WMP alleviated colitis-associated colon cancer (CAC) by inhibiting inflammation and oxidative stress through AHCY-mediated hedgehog signaling. These findings suggest that WMP may be a promising therapeutic candidate for CRC.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

添加到收藏夹

Article Public, Environmental & Occupational Health

Landscape and predictions of inflammatory bowel disease in China: China will enter the Compounding Prevalence stage around 2030

Bule Shao et al.

Summary: This study aimed to explore the epidemiological trends of inflammatory bowel disease (IBD) in China and found that the number of IBD cases and the incidence rate have significantly increased over the past three decades. It is predicted that the incidence of IBD in China will continue to rise over the next 25 years until it stabilizes around 2030, and despite a decreasing age-standardized mortality rate, the number of IBD-related deaths will continue to increase.

FRONTIERS IN PUBLIC HEALTH (2022)

添加到收藏夹

Review Gastroenterology & Hepatology

The emerging role of neutrophilic extracellular traps in intestinal disease

Feng Chen et al.

Summary: This review summarizes the latest knowledge on the formation mechanisms of neutrophil extracellular traps (NETs) and their pathophysiological roles in a variety of intestinal diseases, aiming to provide essential directional guidance and theoretical basis for clinical interventions and the exploration of mechanisms underlying NETs and targeted therapies.

GUT PATHOGENS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Chang qing formula ameliorates colitis-associated colorectal cancer via suppressing IL-17/NF-κB/STAT3 pathway in mice as revealed by network pharmacology study

Qihan Luo et al.

Summary: This study used network pharmacology and transcriptomics to analyze the potential mechanism of action of Chang Qing formula (CQF) in treating colitis-associated colorectal cancer (CAC). The results showed that CQF exerted a tumor-suppressive effect by inhibiting the IL-17 signaling pathway and improving the inflammatory tumor microenvironment. These findings may contribute to the development of future strategies for the treatment of CAC.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Physiology

Qingchang Wenzhong Decoction Prevents the Occurrence of Intestinal Tumors by Regulating Intestinal Microbiota and Gasdermin E

Lingli Ren et al.

Summary: In this study, we found that QCWZD can prevent the occurrence of intestinal tumors by regulating the composition of intestinal microbiota, improving the function of the intestinal barrier, and inhibiting GSDME mediated pyroptosis.

FRONTIERS IN PHYSIOLOGY (2022)

添加到收藏夹

Article Nutrition & Dietetics

Dietary Goji Shapes the Gut Microbiota to Prevent the Liver Injury Induced by Acute Alcohol Intake

Lin Guo et al.

Summary: This study found that Goji berries can prevent liver injury induced by acute alcohol intake by targeting the gut microbiota. Goji supplementation improved acute liver injury and maintained the integrity of the intestinal epithelial barrier. The study also confirmed the causal relationship between gut microbiota and the liver protective effects of Goji through antibiotic treatment and fecal microbiota transplantation.

FRONTIERS IN NUTRITION (2022)

添加到收藏夹

Article Immunology

Composition and diverse differences of intestinal microbiota in ulcerative colitis patients

Siying Zhu et al.

Summary: This study found that there were significant differences in the richness and diversity of the intestinal microbiota among ulcerative colitis (UC) patients, patients in remission, and healthy control subjects. UC patients with active disease had higher levels of potential pathogens and lower levels of butyrate-producing bacteria. Different bacterial taxa could serve as biomarkers, expanding our understanding of the relationship between the intestinal microbiota microenvironment and UC.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Huoxiang Zhengqi alleviates azoxymethane/dextran sulfate sodium-induced colitis-associated cancer by regulating Nrf2/NF-κB/NLRP3 signaling

Mingyuan Dong et al.

Summary: Huoxiang Zhengqi (HXZQ), a classical Chinese herbal medicine, has anti-inflammatory effects on colitis-associated cancer (CAC) by modulating gut microbiota and metabolism, activating antioxidant response, and inhibiting inflammation-mediated NLRP3 inflammasome activation.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Review Oncology

Tumor-Associated Neutrophils in Colorectal Cancer Development, Progression and Immunotherapy

Wei Zheng et al.

Summary: Tumor-associated neutrophils (TANs) play a crucial role in the occurrence and progression of tumors, and hold potential as a new target for CRC immunotherapy, especially for improving the efficacy of ICIs in MSS CRC patients.

CANCERS (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Inflammatory Bowel Disease-Associated Colorectal Cancer Epidemiology and Outcomes: An English Population-Based Study

Rebecca J. Birch et al.

Summary: This study investigated the epidemiology and outcomes of inflammatory bowel disease-associated colorectal cancer (IBD-CRC). It found that IBD patients have a higher risk of developing CRC, are diagnosed at a younger age, and have worse outcomes compared to sporadic CRC. Further research is needed to understand the reasons behind these differences and inform screening, surveillance, and treatment strategies for this high-risk group.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Cumulative Histologic Inflammation Predicts Colorectal Neoplasia in Ulcerative Colitis: A Validation Study

Olivia Yvellez et al.

Summary: Chronic inflammation in ulcerative colitis (UC) is associated with the development of colorectal neoplasia (CRN). A novel cumulative inflammatory index was found to predict CRN development in UC patients. Overall, cumulative histologic inflammation was significantly associated with the development of CRN in UC patients.

INFLAMMATORY BOWEL DISEASES (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

Xiang Zhang et al.

Summary: High dietary cholesterol leads to sequential progression of steatosis, steatohepatitis, fibrosis and eventually HCC in mice, concomitant with insulin resistance. Cholesterol-induced NAFLD-HCC formation is associated with gut microbiota dysbiosis, with specific bacterial composition changes between stages of liver disease. Alterations in gut bacterial metabolites were also observed with dietary cholesterol intake. Therapies targeting cholesterol and gut microbiota may be effective for preventing NAFLD-HCC.

GUT (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases

Marta Piotrowska et al.

Summary: Nrf2 is a stress-responsive transcription factor that plays a crucial role in maintaining cellular homeostasis. When triggered by oxidative or electrophilic stress, Keapl dissociates from Nrf2, allowing Nrf2 to translocate to the nucleus and induce the expression of anti-oxidative and anti-inflammatory genes. This axis is a promising candidate for the prevention and treatment of inflammatory bowel diseases and their complications.

PHARMACOLOGICAL RESEARCH (2021)

添加到收藏夹

Review Medicine, General & Internal

Management of Crohn Disease A Review

Kelly Cushing et al.

Summary: Crohn disease is a chronic gastrointestinal inflammatory disease that requires early and effective control of inflammation. Treatment options include medication, surgery, and vaccination for infection prevention. Physicians should consider disease severity, patient risk stratification, age, and other clinical factors when determining the best treatment strategy.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

From inflammation to colitis-associated colorectal cancer in inflammatory bowel disease: Pathogenesis and impact of current therapies

Massimo Claudio Fantini et al.

Summary: Patients with UC and CD have an increased risk of developing CRC, with inflammation playing a crucial role in the pathogenesis of CAC. Control of inflammation is pivotal to the prevention of CAC.

DIGESTIVE AND LIVER DISEASE (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Sini Decoction Ameliorates Colorectal Cancer and Modulates the Composition of Gut Microbiota in Mice

Yishan Wang et al.

Summary: Sini Decoction (SND) has been clinically proven effective in cardiomyopathy and inflammatory bowel diseases, but its role in colitis-associated cancer remains unclear. This study found that SND extract can reduce tumor number and size, decrease CRC biomarkers, upregulate beneficial bacteria, and modulate gut microbial community in mice. SND effectively intervenes in colorectal cancer development by regulating intestinal immunity and changing intestinal microbiota composition.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Oncology

Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer-A Promising Signaling Network for Therapeutic Interventions

Oemer Guelluelue et al.

Summary: The interplay between p53 and IAP in CRC has important implications for cancer therapy, affecting cellular apoptosis, cell cycle, and DNA damage response. p53 regulates the expression and activity of IAP family members in cancer cells through transcriptional and post-translational mechanisms.

CANCERS (2021)

添加到收藏夹

Article Microbiology

Caffeic Acid Supplement Alleviates Colonic Inflammation and Oxidative Stress Potentially Through Improved Gut Microbiota Community in Mice

Fan Wan et al.

Summary: Caffeic acid (CA) effectively alleviates DSS-induced colitis by improving defense against oxidative stress and inflammatory response, potentially through regulating related pathways and altering gut microbiome composition.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Review Oncology

Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition

Mana Taki et al.

Summary: Epithelial-mesenchymal transition (EMT) plays a critical role in tumor development by interacting with immune evasion mechanisms, leading to tumor progression. Combination therapy targeting EMT and immunosuppression may offer promising new therapeutic approaches in cancer treatment.

CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer

Kristiina Rajamaki et al.

Summary: By comprehensively characterizing IBD-associated tumorigenesis using multiple high-throughput approaches, distinct mechanisms of WNT pathway dysregulation were identified in IBD-CRC, which skew the tumors towards a mesenchymal subtype. Additionally, epigenetic modifications and noncoding mutations in specific genes were found in IBD-CRC, highlighting further differences compared to sCRC.

GASTROENTEROLOGY (2021)

添加到收藏夹

Article Immunology

NLRP3 inflammasome activation triggers gasdermin D-independent inflammation

Chun Wang et al.

Summary: NLRP3 inflammasome, upon sensing pathogen products or sterile danger signals, processes pro-IL-1 beta and pro-IL-18 into bioactive cytokines IL-1 beta and IL-18 with the involvement of GSDMD. However, research shows that even in the absence of GSDMD, NLRP3 activation can still independently trigger inflammatory responses.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Immune System, Microbiota, and Microbial Metabolites: The Unresolved Triad in Colorectal Cancer Microenvironment

Michelle Hanus et al.

Summary: Colorectal cancer (CRC) is a common multifactorial disease influenced by genetic and environmental factors. The tumor microenvironment plays a crucial role in promoting or inhibiting tumor progression, making it a key target for cancer control.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Chemistry, Applied

Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon

Cuiling Guo et al.

Summary: The study found that GLP can reduce AOM/DSS-induced colitis and tumorigenesis, improve dysbiosis, increase short-chain fatty acid production, and enhance gut barrier function.

CARBOHYDRATE POLYMERS (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Inflammatory Bowel Disease-Associated Colorectal Cancer: Translational Risks from Mechanisms to Medicines

Ross J. Porter et al.

Summary: The cumulative impact of chronic inflammation in patients with inflammatory bowel diseases predisposes to the development of IBD-CRC. Inflammation can induce mutagenesis, and the molecular pathogenesis of IBD-CRC is well described, while the immunopathogenesis is less understood. The impact of novel immunosuppressive therapies on achieving deep remission in IBD-CRC remains mostly unknown.

JOURNAL OF CROHNS & COLITIS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Apc-mutant cells act as supercompetitors in intestinal tumour initiation

Sanne M. van Neerven et al.

Summary: In the ISC niche, the delicate balance of WNT agonists and antagonists is crucial for maintaining the ISC compartment and preventing unrestrained activation of the WNT pathway. Apc-mutant ISCs function as supercompetitors by secreting WNT antagonists to induce differentiation of neighboring wild-type ISCs. Lithium chloride prevents the expansion of Apc-mutant clones and adenoma formation by rendering wild-type ISCs insensitive to WNT antagonists through downstream activation of WNT by inhibiting GSK3 beta. Boosting the fitness of healthy cells may be a powerful strategy to limit the formation of cancers in high-risk individuals.

NATURE (2021)

添加到收藏夹

Article Integrative & Complementary Medicine

Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway

Zhang Meng-Meng et al.

Summary: The study demonstrated that PNS can ameliorate colon injury, regulate colonic inflammation, improve gut microbiota composition, and impact the Wnt signaling pathway.

CHINESE JOURNAL OF NATURAL MEDICINES (2021)

添加到收藏夹

Article Microbiology

Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation

Sidhartha R. Sinha et al.

CELL HOST & MICROBE (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Sudabeh Alatab et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Wu Mei Wan attenuates CAC by regulating gut microbiota and the NF-kB/IL6-STAT3 signaling pathway

Feng Jiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

添加到收藏夹

Article Immunology

Enterotoxigenic Bacteroides fragilis: A Possible Etiological Candidate for Bacterially-Induced Colorectal Precancerous and Cancerous Lesions

Samin Zamani et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Immunological Mechanisms in Inflammation-Associated Colon Carcinogenesis

Takehiro Hirano et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Microbiology

Functional and Genomic Variation between Human-Derived Isolates of Lachnospiraceae Reveals Inter- and Intra-Species Diversity

Matthew T. Sorbara et al.

CELL HOST & MICROBE (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Cancer-protective effect of a synbiotic combination betweenLactobacillus gasseri505 and aCudrania tricuspidataleaf extract on colitis-associated colorectal cancer

Nam Su Oh et al.

GUT MICROBES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Biogeography of microbial bile acid transformations along the murine gut

Solenne Marion et al.

JOURNAL OF LIPID RESEARCH (2020)

添加到收藏夹

Article Integrative & Complementary Medicine

Feng-Liao-Chang-Wei-Kang Combined with 5-Fluorouracil Synergistically Suppresses Colitis-Associated Colorectal Cancer via the IL-6/STAT3 Signalling Pathway

Lifan Zhong et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tumor Infiltrating Regulatory T Cells in Sporadic and Colitis-Associated Colorectal Cancer: The Red Little Riding Hood and the Wolf

Massimo Claudio Fantini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Oncology

The Gut Microbiome Is Associated with Clinical Response to Anti-PD-1/PD-L1 Immunotherapy in Gastrointestinal Cancer

Zhi Peng et al.

CANCER IMMUNOLOGY RESEARCH (2020)

添加到收藏夹

Review Oncology

Role of myeloid-derived suppressor cells in the promotion and immunotherapy of colitis-associated cancer

Yungang Wang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹

Article Oncology

Fusobacterium nucleatum Accelerates the Progression of Colitis-Associated Colorectal Cancer by Promoting EMT

Mi Ra Yu et al.

CANCERS (2020)

添加到收藏夹

Review Immunology

The Intestinal Microbiota and Colorectal Cancer

Yiwen Cheng et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study

Chang-Ho Ryan Choi et al.

GUT (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer

Huawei Zeng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

HBD Inhibits the Development of Colitis-Associated Cancer in Mice via the IL-6R/STAT3 Signaling Pathway

Song Deng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Cell Biology

Importance of probiotics in the prevention and treatment of colorectal cancer

Majid Eslami et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

添加到收藏夹

Article Plant Sciences

Chang-wei-qing, a Chinese herbal formula, ameliorates colitis-associated tumour development via inhibiting NF-κB and STAT3 signalling pathway

Guangsheng Wan et al.

PHARMACEUTICAL BIOLOGY (2019)

添加到收藏夹

Article Microbiology

Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation

Jianbo Zhang et al.

BMC MICROBIOLOGY (2019)

添加到收藏夹

Article Plant Sciences

Protective effect of Shaoyao Decoction against colorectal cancer via the Keap1-Nrf2-ARE signaling pathway

Xiaoyan Wang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tumor Microenvironment as A Game Changer in Cancer Radiotherapy

Magdalena Jarosz-Biej et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Immunology

Foxp3 Instability Helps tTregs Distinguish Self and Non-self

Zhongmei Zhang et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Integrative & Complementary Medicine

Uncovering the Anticancer Mechanism of Compound Sophorae Decoction against Ulcerative Colitis-Related Colorectal Cancer in Mice

Shuangjiao Deng et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

添加到收藏夹

Article Immunology

MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps

Avin Hawez et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Oncology

Canmei Formula Reduces Colitis-Associated Colorectal Carcinogenesis in Mice by Modulating the Composition of Gut Microbiota

Huayue Zhang et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Review Cell Biology

New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer

Anushka Dongre et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

添加到收藏夹

Correction Microbiology

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells (vol 23, pg 203, 2018)

Liam Chung et al.

CELL HOST & MICROBE (2018)

添加到收藏夹

Review Gastroenterology & Hepatology

Reduced Risk of Inflammatory Bowel Disease-associated Colorectal Neoplasia with Use of Thiopurines: a Systematic Review and Meta-analysis

Zhehui Zhu et al.

JOURNAL OF CROHNS & COLITIS (2018)

添加到收藏夹

Article Oncology

Glycine and succinic acid are effective indicators of the suppression of epithelial-mesenchymal transition by fucoxanthinol in colorectal cancer stem-like cells

Masaru Terasaki et al.

ONCOLOGY REPORTS (2018)

添加到收藏夹

Review Nutrition & Dietetics

Butyrate: A Double-Edged Sword for Health?

Hu Liu et al.

ADVANCES IN NUTRITION (2018)

添加到收藏夹

Article Oncology

RORγt-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells

Angelamaria Rizzo et al.

CANCER IMMUNOLOGY RESEARCH (2018)

添加到收藏夹

Article Immunology

SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer

Ankit Malik et al.

IMMUNITY (2018)

添加到收藏夹

Review Oncology

Precancer in ulcerative colitis: the role of the field effect and its clinical implications

Kathryn T. Baker et al.

CARCINOGENESIS (2018)

添加到收藏夹

Review Hematology

PD-1 expression and clinical PD-1 blockade in B-cell lymphomas

Zijun Y. Xu-Monette et al.

BLOOD (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediators and Reduces Colitis in Mice

Federica Ungaro et al.

GASTROENTEROLOGY (2017)

添加到收藏夹

Review Ecology

Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics

Mireia Lopez-Siles et al.

ISME JOURNAL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis

D. M. Hardbower et al.

ONCOGENE (2017)

添加到收藏夹

Article Immunology

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T cells

Meike Kespohl et al.

FRONTIERS IN IMMUNOLOGY (2017)

添加到收藏夹

Review Gastroenterology & Hepatology

Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli

Ali Shawki et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB

Laura D'Ignazio et al.

BIOMEDICINES (2017)

添加到收藏夹

Article Oncology

Phenotype, development, and biological function of myeloid-derived suppressor cells

Yang Zhao et al.

ONCOIMMUNOLOGY (2016)

添加到收藏夹

Review Cell Biology

Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer

Zhiqi Wang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

添加到收藏夹

Article Oncology

Protective effects of Huangqin Decoction against ulcerative colitis and associated cancer in mice

Gang Chen et al.

ONCOTARGET (2016)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Mutual Cross-Feeding Interactions between Bifidobacterium longum subsp longum NCC2705 and Eubacterium rectale ATCC 33656 Explain the Bifidogenic and Butyrogenic Effects of Arabinoxylan Oligosaccharides

Audrey Riviere et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)

添加到收藏夹

Article Integrative & Complementary Medicine

Shenling Baizhu San supresses colitis associated colorectal cancer through inhibition of epithelial-mesenchymal transition and myeloid-derived suppressor infiltration

Xiaochang Lin et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

添加到收藏夹

Article Food Science & Technology

Modulation of gut microbiota in rats fed high-fat diets by processing whole-grain barley to barley malt

Yadong Zhong et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki et al.

NATURE (2015)

添加到收藏夹

Article Gastroenterology & Hepatology

The global burden of IBD: from 2015 to 2025

Gilaad G. Kaplan

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2015)

添加到收藏夹

Review Medicine, General & Internal

Cancers Complicating Inflammatory Bowel Disease

Laurent Beaugerie et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

Ayelet Sivan et al.

SCIENCE (2015)

添加到收藏夹

Review Gastroenterology & Hepatology

Mechanisms of Immune Signaling in Colitis-Associated Cancer

Maximilian J. Waldner et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2015)

添加到收藏夹

Review Oncology

Chronic ulcerative colitis and colorectal cancer

Gerhard Rogler

CANCER LETTERS (2014)

添加到收藏夹

Review Gastroenterology & Hepatology

Thiopurines and Risk of Colorectal Neoplasia in Patients With Inflammatory Bowel Disease: A Meta-analysis

Tine Jess et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis

Kathleen Machiels et al.

GUT (2014)

添加到收藏夹

Article Medicine, Research & Experimental

ShaoYao decoction ameliorates colitis-associated colorectal cancer by downregulating proinflammatory cytokines and promoting epithelial-mesenchymal transition

Xiaochang Lin et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis

Marco Scarpa et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

添加到收藏夹

Article Oncology

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

Jie Liang et al.

CANCER CELL (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

Sarah Schwitalla et al.

CELL (2013)

添加到收藏夹

Article Microbiology

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

Aleksandar D. Kostic et al.

CELL HOST & MICROBE (2013)

添加到收藏夹

Article Cell Biology

Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic Strain Lactobacillus casei Shirota

Elizabeth R. Mann et al.

MEDIATORS OF INFLAMMATION (2013)

添加到收藏夹

Review Immunology

Inflammation and colorectal cancer: colitis-associated neoplasia

Sergei I. Grivennikov

SEMINARS IN IMMUNOPATHOLOGY (2013)

添加到收藏夹

Article Gastroenterology & Hepatology

Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies

Tine Jess et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2012)

添加到收藏夹

Article Gastroenterology & Hepatology

5-Aminosalicylate Is Not Chemoprophylactic for Colorectal Cancer in IBD: A Population Based Study

Charles N. Bernstein et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2011)

添加到收藏夹

Article Cell Biology

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

Dallas R. Donohoe et al.

CELL METABOLISM (2011)

添加到收藏夹

Article Gastroenterology & Hepatology

Ulcerative Colitis-associated Colorectal Cancer Shows a Poorer Survival than sporadic colorectal cancer: A Nationwide Japanese Study

Toshiaki Watanabe et al.

INFLAMMATORY BOWEL DISEASES (2011)

添加到收藏夹

Article Gastroenterology & Hepatology

Bifidobacterium lactis Inhibits NF-κB in Intestinal Epithelial Cells and Prevents Acute Colitis and Colitis-associated Colon Cancer in Mice

Seung Won Kim et al.

INFLAMMATORY BOWEL DISEASES (2010)

添加到收藏夹

Review Gastroenterology & Hepatology

Mechanisms by Which Inflammation May Increase Intestinal Cancer Risk in Inflammatory Bowel Disease

Pamela M. O'Connor et al.

INFLAMMATORY BOWEL DISEASES (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

Dimitrios Iliopoulos et al.

CELL (2009)

添加到收藏夹

Article Gastroenterology & Hepatology

Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort

F. Schnitzler et al.

GUT (2009)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects

G. P. Lambert

JOURNAL OF ANIMAL SCIENCE (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

Apoptosis and colorectal cancer: implications for therapy

Shi Yu Yang et al.

TRENDS IN MOLECULAR MEDICINE (2009)

添加到收藏夹

Review Oncology

STATs in cancer inflammation and immunity: a leading role for STAT3

Hua Yu et al.

NATURE REVIEWS CANCER (2009)

添加到收藏夹

Article Pharmacology & Pharmacy

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

Wenge Li et al.

BIOCHEMICAL PHARMACOLOGY (2008)

添加到收藏夹

Article Oncology

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways

Tamer T. Onder et al.

CANCER RESEARCH (2008)

添加到收藏夹

Article Oncology

Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis

Tin Oo Khor et al.

CANCER RESEARCH (2006)

添加到收藏夹

Article Gastroenterology & Hepatology

5-aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study

TP van Staa et al.

GUT (2005)

添加到收藏夹

Article Nutrition & Dietetics

Prolonged butyrate treatment inhibits the migration and invasion potential of HT1080 tumor cells

HW Zeng et al.

JOURNAL OF NUTRITION (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

FR Greten et al.

CELL (2004)

添加到收藏夹

Review Gastroenterology & Hepatology

Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease

P Munkholm

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2003)

添加到收藏夹

Review Biochemistry & Molecular Biology

Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis

M Chawla-Sarkar et al.

APOPTOSIS (2003)

添加到收藏夹

Review Gastroenterology & Hepatology

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

JA Eaden et al.

GUT (2001)

添加到收藏夹

Article Gastroenterology & Hepatology

Lessons from genetically engineered animal models VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice

AJM Watson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.