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Pathogenesis of cerebral amyloid angiopathy caused by chaotic glymphatics-Mini-review

FRONTIERS IN NEUROSCIENCE (2023)

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Review Clinical Neurology

Prevalence of cerebral amyloid angiopathy: A systematic review and meta-analysis

Lieke Jakel et al.

Summary: Reported prevalence estimates of sporadic cerebral amyloid angiopathy (CAA) vary widely, with differences observed in AD patients and the general population. The study found that CAA prevalence based on pathology is higher than that based on presence of strictly lobar cerebral microbleeds. Both methods yield similar estimated prevalences in cognitively normal elderly, patients with intracerebral hemorrhage, and patients with lobar intracerebral hemorrhage. However, large heterogeneity among neuropathology and MRI protocols calls for standardized assessment and reporting of CAA.

ALZHEIMERS & DEMENTIA (2022)

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Article Multidisciplinary Sciences

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Antoine Drieu et al.

Summary: The study reveals that parenchymal border macrophages (PBMs) are new cellular regulators of cerebrospinal fluid (CSF) flow dynamics. PBMs drive CSF flow by regulating arterial motion and ensuring the smooth access of CSF to perivascular spaces. Decreased PBMs lead to accumulation of extracellular matrix proteins, blocking CSF flow and impairing perfusion and clearance in the central nervous system (CNS). Aging and Alzheimer's disease (AD) affect the function of PBMs, which can be restored by intracisternal injection of macrophage colony-stimulating factor.

NATURE (2022)

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Article Clinical Neurology

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study

Andreas Charidimou et al.

Summary: This study aimed to update and validate the Boston criteria for the diagnosis of cerebral amyloid angiopathy (CAA). The results showed that the Boston criteria version 2.0 had superior accuracy in terms of sensitivity and specificity, and incorporated new MRI markers.

LANCET NEUROLOGY (2022)

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Article Cell Biology

Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries

Xinan Chen et al.

Summary: This study developed imaging and analysis tools based on regularized optimal mass transport theory to investigate cerebrospinal fluid (CSF) flow dynamics and glymphatic transport in a transgenic CAA type 1 rat model. The findings suggest that both glymphatic transport and lymphatic drainage are compromised in CAA, providing potential therapeutic targets for treating CAA-related cognitive decline and dementia.

NATURE AGING (2022)

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Article Multidisciplinary Sciences

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Antoine Drieu et al.

Summary: It is found that PBMs regulate CSF flow dynamics and play an important role in CSF flow. PBMs containing high levels of CD163 and LYVE1 regulate arterial motion that drives CSF flow. Depletion of PBMs through pharmacological or genetic means leads to obstruction of CSF access to perivascular spaces, impacting CNS perfusion and clearance.

NATURE (2022)

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Review Radiology, Nuclear Medicine & Medical Imaging

Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics

Toshiaki Taoka et al.

Summary: This review article introduces the concept of Central Nervous System (CNS) Interstitial Fluidopathy, aiming to enhance the understanding of diseases associated with abnormal interstitial fluid dynamics and develop potential treatment methods.

JAPANESE JOURNAL OF RADIOLOGY (2021)

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Review Neurosciences

Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS

Gianfranco Natale et al.

Summary: Recent studies on nervous lymphatic drainage and the blood-brain barrier have revealed a glymphatic pathway in the brain, similar to the peripheral lymphatic system. This pathway allows for the clearance of waste products from the brain, challenging the classic concept of the brain's immune privilege. Research is also exploring the potential role of the glymphatic pathway in neurodegenerative diseases and other acute neurological disorders.

FRONTIERS IN NEUROSCIENCE (2021)

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Review Clinical Neurology

Glymphatic system, AQP4, and their implications in Alzheimer's disease

Ines Silva et al.

Summary: This article discusses the alternative clearance systems required by the central nervous system in the absence of a conventional lymphatic system. It highlights the importance of the glymphatic system and AQP4 in Alzheimer's disease, as well as the impact of AQP4 mislocalisation on disease progression.

NEUROLOGICAL RESEARCH AND PRACTICE (2021)

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Review Clinical Neurology

Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways

Steven M. Greenberg et al.

NATURE REVIEWS NEUROLOGY (2020)

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Article Neurosciences

Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain

Susanne J. van Veluw et al.

NEURON (2020)

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Article Neurosciences

Modeling glymphatic system of the brain using MRI

Esmaeil Davoodi-Bojd et al.

NEUROIMAGE (2019)

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Article Clinical Neurology

Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI

R. Watts et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2019)

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Article Multidisciplinary Sciences

Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes

Per Kristian Eide et al.

SCIENTIFIC REPORTS (2018)

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Article Biology

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Humberto Mestre et al.

ELIFE (2018)

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Article Medicine, Research & Experimental

Brain-wide glymphatic enhancement and clearance in humans assessed with MRI

Geir Ringstad et al.

JCI INSIGHT (2018)

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Review Anatomy & Morphology

The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy

Andrew Bacyinski et al.

FRONTIERS IN NEUROANATOMY (2017)

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Article Clinical Neurology

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

Alan W. J. Morris et al.

ACTA NEUROPATHOLOGICA (2016)

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Article Oncology

Blood-brain barrier and blood-cerebrospinal fluid barrier in normal and pathological conditions

Masaki Ueno et al.

BRAIN TUMOR PATHOLOGY (2016)

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Review Pharmacology & Pharmacy

β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease

Xiaojuan Sun et al.

FRONTIERS IN PHARMACOLOGY (2015)

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Article Clinical Neurology

Impairment of Paravascular Clearance Pathways in the Aging Brain

Benjamin T. Kress et al.

ANNALS OF NEUROLOGY (2014)

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Article Clinical Neurology

Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI A New Target for Fibrinolysis?

Thomas Gaberel et al.

STROKE (2014)

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Article Neurosciences

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

Jeffrey J. Iliff et al.

JOURNAL OF NEUROSCIENCE (2013)

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Article Multidisciplinary Sciences

Sleep Drives Metabolite Clearance from the Adult Brain

Lulu Xie et al.

SCIENCE (2013)

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Article Clinical Neurology

Is There a Cerebral Lymphatic System?

Jeffrey J. Iliff et al.

STROKE (2013)

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Article Cell Biology

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Jeffrey J. Iliff et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

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