Methylation of BDNF gene in association with episodic memory in women

Brain-derived neurotrophic factor (BDNF) gene regulation plays an important role in long-term memory formation, and the DNA methylation (DNAm) level of BDNF promoters has been associated with episodic memory deficits. Our aim was to explore the association between DNAm levels in BDNF promoter IV with verbal learning and memory performance in healthy women. We conducted a cross-sectional study by recruiting 53 individuals. Episodic memory was assessed by using the Rey Auditory Verbal Learning Test (RAVLT). Clinical interviews, RAVLT, and blood sample collection were assessed in all participants. DNAm was measured on DNA from whole peripheral blood using pyrosequencing. According to generalized linear model (GzLM) analyses, cytosine guanine dinucleotide (CpG) site 5 showed significant associations between learning capacity (LC, p < 0.035), that is, every 1% of DNA methylation at CpG site 5 results in a 0.068 reduction in verbal learning performance. To the best of our knowledge, the current study is the first to show that BDNF DNAm plays an important role in episodic memory.

Automated summary

This study aimed to explore the association between DNAm levels in BDNF promoter IV and verbal learning and memory performance in healthy women. A cross-sectional study was conducted with 53 individuals, and episodic memory was assessed using the Rey Auditory Verbal Learning Test (RAVLT). The results showed that DNAm at CpG site 5 was significantly associated with learning capacity, with a 0.068 reduction in verbal learning performance for every 1% increase in DNAm at CpG site 5.