Increase in conduction velocity in myelinated nerves due to stretch - An experimental verification

Article Neurosciences

Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier

Hirosato Kanda et al.

Summary: Saltatory conduction allows fast propagation of action potentials along myelinated nerves by utilizing the node of Ranvier. The K2P channels TREK-1 and TRAAK were found to be highly expressed in the node of Ranvier and play a crucial role in action potential repolarization. In this study, membrane stretch was shown to increase single-channel event numbers and open probability, as well as decrease membrane excitability. Blockage of TREK-1/TRAAK channels reversed these changes, suggesting their activation suppresses neuronal excitability following axonal stretch. These findings indicate that TREK-1/TRAAK channels may prevent ectopic action potential discharge during intense mechanical nerve stretch.

MOLECULAR BRAIN (2023)

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Article Biochemistry & Molecular Biology

Targeting Two-Pore-Domain Potassium Channels by Mechanical Stretch Instantaneously Modulates Action Potential Transmission in Mouse Sciatic Nerves

Jia Liu et al.

Summary: Recent reports suggest that TRAAK and TREK-1 channels play important roles in action potential repolarization in mammalian peripheral nerves. A new in vitro approach was developed to study the effects of mechanical stretch on nerve conduction, showing that axial stretch leads to increased conduction delay in both myelinated A-fibers and unmyelinated C-fibers. These results highlight the potential for pharmacological and mechanical activation of K2P channels in modulating peripheral nerve function.

ACS CHEMICAL NEUROSCIENCE (2021)

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Review Neurosciences

Function of K2P channels in the mammalian node of Ranvier

Jurgen R. Schwarz

Summary: In myelinated nerve fibres, action potentials are generated at nodes of Ranvier with high density of Na+ channels and K+-selective leakage channels. Recently discovered K2P channels, which can be activated by temperature, mechanical stretch or arachidonic acid, play a crucial role in the functions of nodal K2P channels.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Ultrasonography evaluation of the normal ulnar nerve in adult: Comparison of the cross-sectional area at elbow extension and flexion

Marcel Prasetyo et al.

Summary: This study compared the cross-sectional area (CSA) of the ulnar nerve at elbow extension and flexion positions in healthy adults. The results showed that the CSA of the ulnar nerve was significantly larger at elbow extension compared to flexion, suggesting the importance of considering elbow position in measuring ulnar nerve CSA.

EUROPEAN JOURNAL OF RADIOLOGY OPEN (2021)

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Article Multidisciplinary Sciences