期刊
LANCET
卷 388, 期 10049, 页码 1081-1088出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(16)30579-7
关键词
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资金
- Bill & Melinda Gates Foundation
- US National Institute on Drug Abuse [R01 DA037773-01A1]
- University of California San Diego Center for AIDS Research
- US National Institutes of Health (NIH) - NIH: National Institute of Allergy and Infectious Diseases [P30 AI036214]
- NIH: National Cancer Institute
- NIH: National Institute of Mental Health
- NIH: National Institute on Drug Abuse
- NIH: Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIH: National Heart, Lung, and Blood Institute
- NIH: National Institute on Aging
- NIH: National Institute of General Medical Sciences
- NIH: National Institute of Diabetes and Digestive and Kidney Diseases
- UK Medical Research Council [MR/K01532X/1]
- NIH [5T32HL007093-40]
- Qatar National Research Fund [NPRP 04-924-3-251]
- Biomedical Research Centre of Imperial College National Health Service (NHS) Trust
- Medical Research Council STOP-HCV consortium
- Medical Research Council [MR/K01532X/1] Funding Source: researchfish
- National Institute for Health Research [14/02/17, PDF-2011-04-049] Funding Source: researchfish
- MRC [MR/K01532X/1] Funding Source: UKRI
Background With recent improvements in vaccines and treatments against viral hepatitis, an improved understanding of the burden of viral hepatitis is needed to inform global intervention strategies. We used data from the Global Burden of Disease (GBD) Study to estimate morbidity and mortality for acute viral hepatitis, and for cirrhosis and liver cancer caused by viral hepatitis, by age, sex, and country from 1990 to 2013. Methods We estimated mortality using natural history models for acute hepatitis infections and GBD's cause-of-death ensemble model for cirrhosis and liver cancer. We used meta-regression to estimate total cirrhosis and total liver cancer prevalence, as well as the proportion of cirrhosis and liver cancer attributable to each cause. We then estimated cause-specific prevalence as the product of the total prevalence and the proportion attributable to a specific cause. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost (YLLs) and years lived with disability (YLDs). Findings Between 1990 and 2013, global viral hepatitis deaths increased from 0.89 million (95% uncertainty interval [UI] 0.86-0.94) to 1.45 million (1.38-1.54); YLLs from 31.0 million (29.6-32.6) to 41.6 million (39.1-44.7); YLDs from 0.65 million (0.45-0.89) to 0.87 million (0.61-1.18); and DALYs from 31.7 million (30.2-33.3) to 42.5 million (39.9-45.6). In 2013, viral hepatitis was the seventh (95% UI seventh to eighth) leading cause of death worldwide, compared with tenth (tenth to 12th) in 1990. Interpretation Viral hepatitis is a leading cause of death and disability worldwide. Unlike most communicable diseases, the absolute burden and relative rank of viral hepatitis increased between 1990 and 2013. The enormous health loss attributable to viral hepatitis, and the availability of effective vaccines and treatments, suggests an important opportunity to improve public health.
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