Metal-Free Photoredox Intramolecular Cyclization of N-Aryl Acrylamides

A novel metal-free photoredox-catalyzed cyclization reaction of N-aryl acrylamide is herein reported that provides synthetically valuable oxindole derivatives through the bis-mediation of H2O and aldehyde. In this work, sustainable visible light was used as the energy source, and the organic light-emitting molecule 4CzIPN served as the efficient photocatalyst. The main characteristics of this reaction are environmentally friendly and high yields.

Automated summary

A novel metal-free photoredox-catalyzed cyclization reaction of N-aryl acrylamide is presented, which produces valuable oxindole derivatives through the mediation of H2O and aldehyde. Sustainable visible light was employed as the energy source, and the organic light-emitting molecule 4CzIPN acted as the efficient photocatalyst. The main features of this reaction are environmentally-friendly conditions and high yields.