4.6 Article

Molecular profiling of colorectal cancer in a genetically admixed Hispanic population

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Mathematical & Computational Biology

HNRNPA2B1 Demonstrates Diagnostic and Prognostic Values Based on Pan-Cancer Analyses

Chaoyang Chen et al.

Summary: The study discovered that HNRNPA2B1 is overexpressed in various types of cancer and is associated with poor prognosis. The methylation levels of HNRNPA2B1 in lung adenocarcinoma (LUAD) have different prognostic outcomes. Additionally, HNRNPA2B1 is associated with cancer-associated fibroblasts and participates in spliceosome and cell cycle signaling pathways.

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2022)

Article Oncology

Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations

Jian Carrot-Zhang et al.

Summary: This study found significant associations between Native American ancestry and somatic genomic landscape in lung cancer patients, suggesting that germline genetics may play a key role in tumor mutation burden and specific driver mutations. Further studies are needed to identify the genetic alleles underlying the variation in EGFR and KRAS mutation frequencies.

CANCER DISCOVERY (2021)

Article Oncology

Encorafenib Plus Cetuximab as a New Standard of Care for Previously Treated BRAF V600E-Mutant Metastatic Colorectal Cancer: Updated Survival Results and Subgroup Analyses from the BEACON Study

Josep Tabernero et al.

Summary: The study evaluated different treatment regimens for patients with BRAF V600E-mutant metastatic colorectal cancer, showing that encorafenib plus cetuximab improved overall survival, objective response rate, and progression-free survival compared to standard chemotherapy.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Review Oncology

The Role of p53 Signaling in Colorectal Cancer

Magdalena C. Liebl et al.

Summary: The transcription factor p53 is a crucial tumor suppressor that is often mutated or dysregulated in colorectal cancer (CRC), promoting tumorigenesis. Mutations in p53 reduce its tumor suppressor activity and can even provide neo-morphic functions that contribute to cancer development.

CANCERS (2021)

Review Oncology

The heterogeneous clinical and pathological landscapes of metastatic Braf-mutated colorectal cancer

Giuseppe Nicolo Fanelli et al.

CANCER CELL INTERNATIONAL (2020)

Review Oncology

HER2 as a Predictive Biomarker and Treatment Target in Colorectal Cancer

Astrid De Cuyper et al.

CLINICAL COLORECTAL CANCER (2020)

Article Medicine, General & Internal

Prevalence of the BRAF p.v600e variant in patients with colorectal cancer from Mexico and its estimated frequency in Latin American and Caribbean populations

Jesus Arturo Hernandez-Sandoval et al.

JOURNAL OF INVESTIGATIVE MEDICINE (2020)

Article Multidisciplinary Sciences

Mutation profiling of cancer drivers in Brazilian colorectal cancer

Wellington dos Santos et al.

SCIENTIFIC REPORTS (2019)

Article Pharmacology & Pharmacy

HER2-targeted therapy: an emerging strategy in advanced colorectal cancer

Anna La Salvia et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2019)

Article Multidisciplinary Sciences

KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan

Muhammad Awidi et al.

PLOS ONE (2019)

Article Genetics & Heredity

Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos

Julyann Perez-Mayoral et al.

HUMAN GENOMICS (2019)

Article Biochemistry & Molecular Biology

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

Katherine A. Hoadley et al.

Article Cell Biology

PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer

Qiang Wang et al.

CELL DEATH & DISEASE (2018)

Article Multidisciplinary Sciences

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Dung T. Le et al.

SCIENCE (2017)

Article Gastroenterology & Hepatology

Increased Frequency of KRAS Mutations in African Americans Compared with Caucasians in Sporadic Colorectal Cancer

Jonas J. Staudacher et al.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2017)

Article Medicine, General & Internal

CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer

Piero Dalerba et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Oncology

A meta-analysis of MSI frequency and race in colorectal cancer

Hassan Ashktorab et al.

ONCOTARGET (2016)

Review Oncology

Molecular pathogenesis of sporadic colorectal cancers

Hidetsugu Yamagishi et al.

CHINESE JOURNAL OF CANCER (2016)

Article Oncology

Molecular Biomarkers of Colorectal Cancer and Cancer Disparities: Current Status and Perspective

Upender Manne et al.

CURRENT COLORECTAL CANCER REPORTS (2016)

Editorial Material Cell Biology

Roles of CDKN1B in cancer?

Barbara Belletti et al.

AGING-US (2015)

Article Oncology

Racial Differences in BRAF/KRAS Mutation Rates and Survival in Stage III Colon Cancer Patients

Harry H. Yoon et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

Article Oncology

Racial Differences in BRAF/KRAS Mutation Rates and Survival in Stage III Colon Cancer Patients

Harry H. Yoon et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

Article Medicine, General & Internal

KRAS gene somatic mutations in Chilean patients with colorectal cancer

Claudia Hurtado et al.

REVISTA MEDICA DE CHILE (2014)

Article Biotechnology & Applied Microbiology

K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011

Yelitza Ruiz-Candelaria et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2013)

Article Multidisciplinary Sciences

Comprehensive molecular characterization of human colon and rectal cancer

Donna M. Muzny et al.

NATURE (2012)

Article Gastroenterology & Hepatology

Colorectal cancer molecular biology moves into clinical practice

Colin C. Pritchard et al.

Article Oncology

Mismatch repair protein expression and colorectal cancer in Hispanics from Puerto Rico

Wilfredo E. De Jesus-Monge et al.

FAMILIAL CANCER (2010)

Article Multidisciplinary Sciences

Genome-wide patterns of population structure and admixture among Hispanic/Latino populations

Katarzyna Bryc et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Testing the importance of p27 degradation by the SCFskp2 oathwav in murine models of lung and colon cancer

Inke Timmerbeul et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)