The senile plaque: Morphological differences in APP knock-in mice brains by fixatives

The morphology of senile plaques depends on the APP knock-in mice brain fixative. Solid forms of senile plaques were detected in APP knock-in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as the brain of AD patients. A beta 42 was deposited as cored plaques and A beta 38 accumulated around A beta 42.

Automated summary

The morphology of senile plaques in APP knock-in mice brain is influenced by the fixative used. Solid forms of senile plaques similar to those found in the brains of AD patients were observed in APP knock-in mice brain treated with formic acid, Davidson's fluid fixative, and Bouin's fluid fixative. A beta 42 was found as cored plaques, while A beta 38 accumulated around A beta 42.