☆ 4.7 Article

Identification of schizophrenia symptom-related gene modules by postmortem brain transcriptome analysis

TRANSLATIONAL PSYCHIATRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Psychiatry

Epigenetics and first-episode psychosis: A systematic review

Laura Lockwood et al.

Summary: This systematic review examined 17 studies related to epigenetic changes in first-episode psychosis, finding evidence of epigenetic alterations in certain portions of the genome in early psychosis patients. Further research in this area is warranted for more definitive epigenetic correlations.

PSYCHIATRY RESEARCH (2022)

添加到收藏夹

Article Psychiatry

Glycine transporters in schizophrenia. A new hope or informational noise?

Przemyslaw Zakowicz et al.

Summary: This article presents a systematic review of the role of glycine transporter (GlyT1) inhibitors in schizophrenia treatment. GlyT1 inhibitors have the potential to search for novel substances in the treatment of negative symptoms, but their ability to reduce cognitive deficits is not yet proven.

PSYCHIATRIA POLSKA (2022)

添加到收藏夹

Article Neurosciences

Dysregulation of DPYSL2 expression by mTOR signaling in schizophrenia: Multi-level study of postmortem brain

Ryuta Izumi et al.

Summary: This study found that the expression levels of S6 were lower in patients with schizophrenia, and there is a correlation between mTOR signaling and DPYSL2. This provides new insights for the treatment of schizophrenia.

NEUROSCIENCE RESEARCH (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Epigenetics of Psychosis: A Structured Review with Representative Loci

Christine L. Miller

Summary: The evidence supports the presence of environmental factors in chronic psychotic disorders, and research on the epigenetic manifestations of these factors has begun. This review focuses on three genes, MCHR1, AKT1, and TDO2, as models for differential methylation, and explores the environmental factors associated with psychotic disorders and their interaction with these genes. The location of transcription factor motifs relative to key methylation sites is evaluated and evidence is presented for methylation directing alternative splicing. Experimental results from key studies show differential methylation patterns in psychosis cases versus controls, the influence of pre-existing methylation patterns on brain activation following acute administration of psychosis-eliciting environmental stimuli, and a pattern of methylation associated with developmental risk factors for psychosis.

BIOMEDICINES (2022)

添加到收藏夹

Article Immunology

Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

Mohammad Ahangari et al.

Summary: Despite a negligible genetic correlation, there is polygenic overlap between schizophrenia and multiple sclerosis, with substantial genetic enrichment in each disorder conditional on associations with the other. Leveraging this cross-disorder enrichment, 36 loci jointly associated with schizophrenia and multiple sclerosis were identified at conjunctional FDR < 0.05 with mixed direction of effects. By conducting functional analysis, candidate genes and biological processes related to immune response and B-cell receptor signaling pathways were implicated in the shared genetic architecture of these two disorders.

BRAIN BEHAVIOR AND IMMUNITY (2022)

添加到收藏夹

Review Neurosciences

Cerebral Organoids and Antisense Oligonucleotide Therapeutics: Challenges and Opportunities

Jenny Lange et al.

Summary: The use of stem cell-derived cerebral organoids has improved our understanding of neurological diseases. Antisense oligonucleotides (ASOs) have shown advancements in modifying gene expression and treating diseases such as epilepsy and neuromuscular disorders. Cerebral organoids provide a platform to evaluate personalized ASO therapies and overcome challenges faced by ASO treatments.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

添加到收藏夹

Review Psychiatry

Antipsychotic Drug Development: From Historical Evidence to Fresh Perspectives

Katrina Weston-Green

Summary: Schizophrenia is a complex disorder with varied symptoms, and there is a need for improved treatment options. By understanding the basic science and pharmacological mechanisms of new drugs, it is possible to target specific sub-populations of patients for more effective treatment. This approach to schizophrenia treatment may be more achievable and beneficial than treating it as a homogeneous disorder.

FRONTIERS IN PSYCHIATRY (2022)

添加到收藏夹

Article Psychiatry

The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia

Hongna Li et al.

Summary: This study reveals the association between altered TLR4 signaling pathway activity and deficits in cognition and white matter integrity in schizophrenia.

FRONTIERS IN PSYCHIATRY (2022)

添加到收藏夹

Article Genetics & Heredity

A cross-population atlas of genetic associations for 220 human phenotypes

Saori Sakaue et al.

Summary: The study conducted deep-phenotype genome-wide association studies in BioBank Japan, identifying approximately 5,000 new loci and improving the resolution of the genomic map of human traits. By decomposing matrices of phenome-wide summary statistics, responsible variants and biological mechanisms underlying current disease classifications across populations were pinpointed.

NATURE GENETICS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson's disease

Analia Bortolozzi et al.

Summary: Understanding of RNA's role in health and disease has advanced significantly in the past decade, making oligonucleotides a crucial therapeutic strategy. Challenges in treating brain disorders include delivering oligonucleotides to the brain and targeting specific neuronal populations.

PHARMACOLOGY & THERAPEUTICS (2021)

添加到收藏夹

Article Cell Biology

First Episode Psychosis and Schizophrenia Are Systemic Neuro-Immune Disorders Triggered by a Biotic Stimulus in Individuals with Reduced Immune Regulation and Neuroprotection

Michael Maes et al.

Summary: Schizophrenia is characterized by activation of immune-inflammatory response, compensatory immune-regulatory systems, and lowered neuroprotection. Studies on antipsychotic-naive first episode psychosis and schizophrenia patients are important in understanding the pathogenesis of schizophrenia. The research focused on protein-protein interaction networks, highlighting associations with peripheral immune response, neuroinflammation, and pathways related to immune molecules, neurotrophins, and cell junction organization.

CELLS (2021)

添加到收藏夹

Article Genetics & Heredity

The relationship of childhood trauma and DNA methylation of NMDA receptor genes in first-episode schizophrenia

Camila M. Loureiro et al.

Summary: The study found that childhood trauma may influence DNA methylation in individuals with a predisposition to psychosis, but not in those with frank schizophrenia or controls.

EPIGENOMICS (2021)

添加到收藏夹

Review Genetics & Heredity

The omnigenic model and polygenic prediction of complex traits

Iain Mathieson

Summary: The omnigenic model explains the highly polygenic architecture of complex traits and the low transferability of polygenic scores between populations. Most GWAS variants show differing effects between populations, making it difficult to interpret their clinical and evolutionary implications without a clear model of genetic architecture.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

添加到收藏夹

Review Cell Biology

Copy number variation and neuropsychiatric illness

Elliott Rees et al.

Summary: Copy number variants (CNVs) at specific loci have been identified as important risk factors for several neuropsychiatric disorders, with pleiotropic effects and associations with cognitive impairment and other medical morbidities. While most neuropsychiatric CNVs are multigenic, gene-set analyses have implicated specific genes related to neuropsychiatric disorders. Future whole-genome sequencing studies have the potential to identify novel single-gene CNV associations, providing insights into the pathophysiology underlying these disorders.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Decreased Brain pH and Pathophysiology in Schizophrenia

Hae-Jeong Park et al.

Summary: Postmortem studies have shown that schizophrenia patients have lower brain pH levels, with implications for the role of this phenomenon in disease progression being discussed in depth. Changes in mitochondrial morphology and function in schizophrenia patients may contribute to abnormal metabolism. Alterations in pH levels could have effects on neuronal activity and pathophysiology.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evidence for Altered Phosphoinositide Signaling-Associated Molecules in the Postmortem Prefrontal Cortex of Patients with Schizophrenia

Yasuto Kunii et al.

Summary: Phosphoinositides play crucial roles in the brain functioning, and their metabolic pathways have been shown to be associated with the pathophysiology of schizophrenia. This study investigated the expression levels of PI signaling-associated proteins in the postmortem brains of schizophrenia patients and found lower expression of PIK4CA and higher expression of Akt in the prefrontal cortex of these patients. These results suggest that PIK4CA may be involved in the mechanism underlying the pathogenesis of schizophrenia.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Clinical Neurology

Genome-Wide Correlation of DNA Methylation and Gene Expression in Postmortem Brain Tissues of Opioid Use Disorder Patients

Andi Liu et al.

Summary: The study identified differences in gene and epigenetic changes in OUD patients related to astrocyte and glial cell differentiation, suggesting the involvement of complex gene regulatory mechanisms in OUD. Cross-omics analysis revealed OUD-specific immune-related transcription regulators, providing new insights into the disease pathogenesis.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2021)

添加到收藏夹

Article Psychiatry

Abnormality of subcortical volume and resting functional connectivity in adolescents with early-onset and prodromal schizophrenia

Dan Wen et al.

Summary: The study revealed that adolescents with EOS and PDS exhibit abnormalities in brain structure and function, particularly concentrated in the limbic system, including the hippocampus, amygdala, caudate nucleus, cingulate gyrus, and precuneus. These findings suggest a new direction for early intervention and improving the prognosis of schizophrenic patients.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Prognostic value of polygenic risk scores for adults with psychosis

Isotta Landi et al.

Summary: Including polygenic risk scores does not enhance the performance of standard-of-care predictive models for disease outcomes in patients with psychosis, according to research analyzing clinical and genetic data from two multi-ethnic cohorts.

NATURE MEDICINE (2021)

添加到收藏夹

Article Psychiatry

Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome

Esra Sefik et al.

Summary: The study uncovered the convergent and distributed effects of 3q29 deletion on the cortical transcriptome, implicating functions related to the nervous system and core cellular activities. Additionally, the top network-neighbors of 3q29 genes showed significant overlap with known risk genes for schizophrenia, autism, and intellectual disabilities, indicating the relevance of 3q29DeI biology to idiopathic diseases. Furthermore, leveraging guilt by association, the researchers proposed nine prioritized driver genes for neuropsychiatric risk.

TRANSLATIONAL PSYCHIATRY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

Eugenia Radulescu et al.

MOLECULAR PSYCHIATRY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Gene expression predictions and networks in natural populations supports the omnigenic theory

Aurelien Chateigner et al.

BMC GENOMICS (2020)

添加到收藏夹

Article Psychiatry

Gene expression meta-analysis reveals the up-regulation of CREB1 and CREBBP in Brodmann Area 10 of patients with schizophrenia

Shay Ohayon et al.

PSYCHIATRY RESEARCH (2020)

添加到收藏夹

Article Psychiatry

Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder

Jill R. Glausier et al.

AMERICAN JOURNAL OF PSYCHIATRY (2020)

添加到收藏夹

Review Psychiatry

The past and future of novel, non-dopamine-2 receptor therapeutics for schizophrenia: A critical and comprehensive review

Ragy R. Girgis et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

A decade in psychiatric GWAS research

Tanya Horwitz et al.

MOLECULAR PSYCHIATRY (2019)

添加到收藏夹

Article Cell Biology

A comparative system-level analysis of the neurodegenerative diseases

Rasoul Godini et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

添加到收藏夹

Article Genetics & Heredity

GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function

Helene A. Fachim et al.

EPIGENOMICS (2019)

添加到收藏夹

Article Neurosciences

The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia

Alexandros Rammos et al.

NEUROPSYCHOPHARMACOLOGY (2019)

添加到收藏夹

Article Psychiatry

Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder

Jinting Guan et al.

TRANSLATIONAL PSYCHIATRY (2019)

添加到收藏夹

Article Psychiatry

DLPFC transcriptome defines two molecular subtypes of schizophrenia

Elijah F. W. Bowen et al.

TRANSLATIONAL PSYCHIATRY (2019)

添加到收藏夹

Article Medicine, General & Internal

Investigation of betaine as a novel psychotherapeutic for schizophrenia

Tetsuo Ohnishi et al.

EBIOMEDICINE (2019)

添加到收藏夹

Article Psychiatry

Schizophrenia Polygenic Risk Score as a Predictor of Antipsychotic Efficacy in First-Episode Psychosis

Jian-Ping Zhang et al.

AMERICAN JOURNAL OF PSYCHIATRY (2019)

添加到收藏夹

Article Psychiatry

Schizophrenia polygenic risk score and 20-year course of illness in psychotic disorders

Katherine G. Jonas et al.

TRANSLATIONAL PSYCHIATRY (2019)

添加到收藏夹

Article Psychiatry

Inflammatory biomarkers in psychosis and clinical high risk populations

Shannon Delaney et al.

SCHIZOPHRENIA RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders

X. Xiao et al.

MOLECULAR PSYCHIATRY (2018)

添加到收藏夹

Article Neurosciences

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Hideo Hagihara et al.

NEUROPSYCHOPHARMACOLOGY (2018)

添加到收藏夹

Article Psychiatry

Hippocampal Subfield Volumes in Patients With First-Episode Psychosis

Valentina Baglivo et al.

SCHIZOPHRENIA BULLETIN (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Douglas M. Ruderfer et al.

CELL (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Influence of correlation between HLA-G polymorphism and Interleukin-6 (IL6) gene expression on the risk of schizophrenia

Venkataram Shivakumar et al.

CYTOKINE (2018)

添加到收藏夹

Article Genetics & Heredity

Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets

David Curtis

PSYCHIATRIC GENETICS (2018)

添加到收藏夹

Review Psychiatry

The use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: Systematic review

Sumit Mistry et al.

SCHIZOPHRENIA RESEARCH (2018)

添加到收藏夹

Article Genetics & Heredity

A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains

Siri Ranlund et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2018)

添加到收藏夹

Review Clinical Neurology

Neuropsychiatric syndromes of multiple sclerosis

Ruth Murphy et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)

添加到收藏夹

Article Medicine, Research & Experimental

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model

Hien Tran Zhao et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

An Expanded View of Complex Traits: From Polygenic to Omnigenic

Evan A. Boyle et al.

CELL (2017)

添加到收藏夹

Article Psychiatry

Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia

Mizuki Hino et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2016)

添加到收藏夹

Article Genetics & Heredity

Next-generation genotype imputation service and methods

Sayantan Das et al.

NATURE GENETICS (2016)

添加到收藏夹

Article Psychiatry

Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population

Hannah J. Jones et al.

JAMA PSYCHIATRY (2016)

添加到收藏夹

Article Psychiatry

Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts

H. C. Whalley et al.

TRANSLATIONAL PSYCHIATRY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

A global reference for human genetic variation

David M. Altshuler et al.

NATURE (2015)

添加到收藏夹

Article Biology

Second-generation PLINK: rising to the challenge of larger and richer datasets

Christopher C. Chang et al.

GIGASCIENCE (2015)

添加到收藏夹

Article Biochemical Research Methods

PRSice: Polygenic Risk Score software

Jack Euesden et al.

BIOINFORMATICS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility

M. Li et al.

MOLECULAR PSYCHIATRY (2014)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

SEARCHING FOR SCHIZ OPHRENIA'S ROOTS

Emily Elert

NATURE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Biological insights from 108 schizophrenia-associated genetic loci

Stephan Ripke et al.

NATURE (2014)

添加到收藏夹

Article Geriatrics & Gerontology

Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson's disease

Taku Hatano et al.

NEUROBIOLOGY OF AGING (2014)

添加到收藏夹

Article Psychiatry

A Population-Based Study of Genetic Variation and Psychotic Experiences in Adolescents

Stanley Zammit et al.

SCHIZOPHRENIA BULLETIN (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Copy number variation at 22q11.2: from rare variants to common mechanisms of developmental neuropsychiatric disorders

N. Hiroi et al.

MOLECULAR PSYCHIATRY (2013)

添加到收藏夹

Review Genetics & Heredity

Human diseases through the lens of network biology

Laura I. Furlong

TRENDS IN GENETICS (2013)

添加到收藏夹

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

Shaun M. Purcell et al.

NATURE (2009)

添加到收藏夹

Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

添加到收藏夹

Article Neurosciences

Effect of agonal and postmortem factors on gene expression profile: Quality control in microarray analyses of postmortem human brain

H Tomita et al.

BIOLOGICAL PSYCHIATRY (2004)

添加到收藏夹

Article Geriatrics & Gerontology

The impact upon extra-pyramidal side effects, clinical symptoms and quality of life of a switch from conventional to atypical antipsychotics (risperidone or olanzapine) in elderly patients with schizophrenia

CW Ritchie et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.