☆ 4.6 Review

Progress on innate immune evasion and live attenuated vaccine of pseudorabies virus

FRONTIERS IN MICROBIOLOGY (2023)

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Article Veterinary Sciences

The recombinant pseudorabies virus expressing porcine deltacoronavirus spike protein is safe and effective for mice

Yao Huang et al.

Summary: In this study, a recombinant virus expressing the spike protein of PDCoV was constructed and evaluated for its safety and immunogenicity in mice. The results showed that the recombinant virus was safe and induced a strong immune response in mice. Additionally, it provided protection against virus challenge and accelerated the detoxification of PDCoV.

BMC VETERINARY RESEARCH (2022)

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Article Microbiology

Pseudorabies virus UL16 protein influences the inhibition of LRPPRC for the viral proliferation

Jingjing Xu et al.

Summary: This study investigates the function of pUL16 in pseudorabies virus (PRV) infection and explores the cellular pathways in which pUL16 may participate. The interaction between LRPPRC and PRV pUL16 was identified, suggesting the involvement of UL16 in redox reactions or cellular apoptosis. This is the first study to examine the interaction between pUL16 and host proteins, providing valuable insights into the understanding of pUL16.

VETERINARY MICROBIOLOGY (2022)

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Article Virology

Construction of a quadruple gene-deleted vaccine confers complete protective immunity against emerging PRV variant challenge in piglets

Leqiang Sun et al.

Summary: PRV GDFS-delgI/gE/US9/US2 strain is a potential new live attenuated vaccine against emerging PRV variant strain infections in China.

VIROLOGY JOURNAL (2022)

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Article Veterinary Sciences

Construction and Immunogenicity of a Recombinant Pseudorabies Virus Variant With TK/gI/gE/11k/28k Deletion

Shijun Yan et al.

Summary: In China, a variant strain of pseudorabies virus (PRV) has caused large-scale outbreaks in swine herds vaccinated with classical PRV vaccines since 2011. Researchers have constructed a recombinant PRV based on the variant HN1201 strain, which showed similar growth characteristics and smaller plaques compared to the parental virus. Vaccination with this recombinant PRV elicited earlier and higher levels of antibodies, providing protective immunity against both classical and variant strains of PRV. Clinically, pigs immunized with the recombinant PRV showed lower body temperature and were protected against infection with the variant PRV strain. These results suggest that this recombinant PRV could be a promising vaccine candidate for preventing the current pseudorabies epidemic in China.

FRONTIERS IN VETERINARY SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Pseudorabies virus kinase UL13 phosphorylates H2AX to foster viral replication

Xin Ming et al.

Summary: The PRV infection activates ATM and DNA-PK signaling pathways, while the PRV-encoded kinase UL13 interacts with and phosphorylates H2AX. Deletion of UL13 attenuates PRV neuroinvasiveness and virulence in vivo. UL13-mediated H2AX phosphorylation plays a pivotal role in efficient PRV replication and progeny production.

FASEB JOURNAL (2022)

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Review Medicine, General & Internal

Immunity to SARS-CoV-2 induced by infection or vaccination

Xaquin Castro Dopico et al.

Summary: Adaptive immune responses are crucial for viral clearance and protection against re-infection, including SARS-CoV-2. The rapid characterization of the immune response to the virus during the first 20 months of the pandemic has provided a detailed understanding. The development and global rollout of effective COVID-19 vaccines have made a significant impact, although challenges remain in terms of equal access.

JOURNAL OF INTERNAL MEDICINE (2022)

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Article Virology

A noval strategy of deletion in PK gene for construction of a vaccine candidate with exellent safety and complete protection efficiency against high virulent Chinese pseudorabies virus variant

Mengwei Xu et al.

Summary: The virulence of PRV Delta TK&PK&gE-AH02 was significantly mitigated, making it a promising vaccine candidate for controlling virulent PRV variants in China.

VIRUS RESEARCH (2022)

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Review Virology

A Tug of War: Pseudorabies Virus and Host Antiviral Innate Immunity

Guangqiang Ye et al.

Summary: The non-specific innate immunity is the first line of defense for the host to resist pathogenic microorganisms. Pseudorabies virus (PRV) is a causative agent of a lethal disease, mainly infecting the nervous system in pigs and causing acute death in other species as well. The review summarizes the strategies of PRV evading host innate immunity and explores new targets for inhibiting PRV replication.

VIRUSES-BASEL (2022)

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Review Virology

A Review of Pseudorabies Virus Variants: Genomics, Vaccination, Transmission, and Zoonotic Potential

Zongyi Bo et al.

Summary: Research on PRV variants has made significant progress, but further exploration of its replication, pathogenicity, and transmission mechanisms is still needed in order to ultimately eradicate the virus in China.

VIRUSES-BASEL (2022)

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Article Microbiology

Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity

Zhengjie Kong et al.

Summary: This study reveals that UL13 protein of PRV inhibits STING-mediated antiviral signaling by regulating the stability of STING. UL13 interacts with STING and recruits E3 ligase RNF5 to degrade STING, persistently evading host antiviral responses. These findings provide a new target for the development of gene-deleted vaccine for pseudorabies.

PLOS PATHOGENS (2022)

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Article Microbiology

The Construction and Immunogenicity Analyses of Recombinant Pseudorabies Virus With NADC30-Like Porcine Reproductive and Respiratory Syndrome Virus-Like Particles Co-expression

Jun Zhao et al.

Summary: In this study, a recombinant pseudorabies virus (rPRV)-NC56 vaccine was constructed, which showed promising results in protecting against NADC30-like PRRSV and PRV. The vaccine induced specific immune responses in mice and provided complete protection against virulent PRV strains.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Veterinary Sciences

Construction and Evaluation of Recombinant Pseudorabies Virus Expressing African Swine Fever Virus Antigen Genes

Liyi Chen et al.

Summary: A recombinant virus expressing African swine fever virus (ASFV) antigen genes was successfully constructed using pseudorabies virus as the viral vector, and its immunogenicity in inducing high levels of antibodies in vivo was validated. These findings are of significance for the development of new ASFV vaccines.

FRONTIERS IN VETERINARY SCIENCE (2022)

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Article Veterinary Sciences

Emergence of a Novel Recombinant Pseudorabies Virus Derived From the Field Virus and Its Attenuated Vaccine in China

Lei Tan et al.

Summary: In this study, a novel recombinant PRV strain called HN-2019 was isolated from a sick piglet and its genetic features and pathogenicity were investigated. The results suggested a natural recombination event might have occurred in the genome of the HN-2019 strain between the PRV classical strain and the HB-98 vaccine strain, providing useful guidelines for future PRV vaccine design.

FRONTIERS IN VETERINARY SCIENCE (2022)

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Article Virology

A novel Pseudorabies virus vaccine developed using HDR-CRISPR/Cas9 induces strong humoral and cellular immune response in mice

Chen Luo et al.

Summary: In this study, a TK/gI/gE deleted recombinant PRV expressing GM-CSF was developed using the HDR-CRISPR/Cas9 system. The recombinant PRV showed higher knock-in efficiency and similar properties to the parental strain. Mice vaccinated with the recombinant PRV were completely protected against wild-type PRV challenge and showed improved antibody responses and immune reactions. This study provides a novel approach for recombinant PRV construction and the triple gene-deleted PRV expressing GM-CSF could be a promising vaccine candidate for PR control.

VIRUS RESEARCH (2022)

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Article Virology

Pseudorabies Virus EP0 Antagonizes the Type I Interferon Response via Inhibiting IRF9 Transcription

Mengdong Wang et al.

Summary: This study reveals that alphaherpesviruses can use their encoded early protein EP0 to inhibit the upregulation of antiviral proteins induced by IFN by reducing the basal expression levels of IRF9 through transcriptional repression. This finding elucidates a mechanism used by alphaherpesviruses to evade the immune response and suggests that EP0 is an important viral protein in pathogenesis and a potential target for antiviral drug development.

JOURNAL OF VIROLOGY (2022)

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Immunostimulatory Polymers as Adjuvants, Immunotherapies, and Delivery Systems

Adam M. Weiss et al.

Summary: This study discusses the application of immunostimulatory polymers in therapeutics and their ability to activate the immune system, as well as the design and delivery methods involved.

MACROMOLECULES (2022)

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A Vaccine Based on Asia1 Shamir of the Foot-and-Mouth Disease Virus Offers Low Levels of Protection to Pigs against Asia1/MOG/05, Circulating in East Asia

Heeyeon Kim et al.

Summary: This study investigated the protective effect of the Asia1 Shamir vaccine against Asia1/MOG/05 virus infection. The results showed that the vaccine delayed the onset of clinical symptoms and reduced virus nasal shedding. Neutralizing antibodies induced after vaccination provided partial immune protection.

VIRUSES-BASEL (2022)

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Porcine Enteric Coronavirus PEDV Induces the ROS-ATM and Caspase7-CAD-γH2AX Signaling Pathways to Foster Its Replication

Xin Ming et al.

Summary: This study reveals that the porcine epidemic diarrhea virus (PEDV) induces DNA damage response (DDR) through the ROS-ATM and caspase7-CAD-gamma H2AX signaling pathways, which facilitates its early replication.

VIRUSES-BASEL (2022)

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Article Virology

Adapting an Atmospheric Dispersion Model to Assess the Risk of Windborne Transmission of Porcine Reproductive and Respiratory Syndrome Virus between Swine Farms

Kaushi S. T. Kanankege et al.

Summary: Modeling the windborne transmission of PRRSv using an atmospheric dispersion model was conducted, and applicable parameter values were determined through literature and expert opinion. A sensitivity analysis and risk estimation based on particle deposition and distance to emitting farm were performed. Farms within a certain distance were found to have the highest risk.

VIRUSES-BASEL (2022)

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Review Virology

Pseudorabies Virus: From Pathogenesis to Prevention Strategies

Hui-Hua Zheng et al.

Summary: Pseudorabies, caused by pseudorabies virus (PRV), is a highly infectious viral disease that affects various mammals including humans and pigs. Despite efforts to control the disease through vaccines and diagnostic methods, pseudorabies remains an important and prevalent infectious disease in the global pig industry.

VIRUSES-BASEL (2022)

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Review Virology

A Comparison of Pseudorabies Virus Latency to Other α-Herpesvirinae Subfamily Members

Jing Chen et al.

Summary: Pseudorabies virus (PRV), a causative agent of Aujeszky's disease, poses a significant threat to the global pig industry with its lifelong latent infection and reactivation from latency. Research indicates that the regulation of PRV latency is influenced by a complex interplay between virus, neurons, and the immune system.

VIRUSES-BASEL (2022)

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Article Virology

Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription

Ningning Zhao et al.

Summary: The UL13 protein of Pseudorabies virus functions as an antagonist of RLR-mediated antiviral responses by suppressing the transcription of RIG-I and MDA5. UL13 suppresses the expression of RIG-I and MDA5 by inhibiting activation of the transcription factor NF-kappa B.

VIRUSES-BASEL (2022)

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Review Cell Biology

Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections

Guangzhi Zhang et al.

Summary: This review summarizes the role of necroptosis during pathogenic infections, especially zoonotic infectious diseases. The review discusses the activation and regulation of necroptosis, the interaction between pathogens and hosts, and provides references and directions for the prevention and control of infectious diseases.

CELL DEATH & DISEASE (2022)

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Review Immunology

Overview of Tools and Measures Investigating Vaccine Hesitancy in a Ten Year Period: A Scoping Review

Elizabeth O. Oduwole et al.

Summary: This scoping review provides a comprehensive overview of vaccine tools and measures from 2010 to 2019, highlighting the need for contextually relevant tools in the African region. Additionally, the critical role of vaccination in controlling the ongoing COVID-19 pandemic is emphasized.

VACCINES (2022)

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Article Veterinary Sciences

Construction and Immunogenicity of a Recombinant Pseudorabies Virus Expressing SARS-CoV-2-S and SARS-CoV-2-N

Ruoying Li et al.

Summary: This study successfully constructed recombinant viruses expressing SARS-CoV-2-S and SARS-CoV-2-N proteins, which provides a reference for future research on live vector vaccines for domestic animals, pets, and wild animals.

FRONTIERS IN VETERINARY SCIENCE (2022)

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Article Veterinary Sciences

Genetic and epidemic characteristics of porcine parvovirus 7 in the Fujian and Guangdong regions of southern China

Xinjie Zhang et al.

Summary: Porcine parvovirus 7 (PPV7) was detected in various porcine samples in South China, and its coinfection with other porcine viruses was determined. PPV7 was found to be highly prevalent in blood, stool, and saliva, but absent in breast milk. The study also revealed a high rate of PPV7 coinfection with porcine circovirus 2 (PCV2), porcine circovirus 3 (PCV3), and porcine reproductive and respiratory syndrome virus (PRRSV). Different subtypes of PPV7 were found to be prevalent in different regions of South China, indicating rich genetic diversity of PPV7 in these areas.

FRONTIERS IN VETERINARY SCIENCE (2022)

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Letter Infectious Diseases

Re-emergence of Severe Acute Diarrhea Syndrome Coronavirus (SADS-CoV) in Guangxi, China, 2021

Yankuo Sun et al.

JOURNAL OF INFECTION (2022)

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Article Microbiology

The canonical Wnt/?-catenin signaling pathway facilitates pseudorabies virus proliferation and enhances virus-induced autophagy

Chongyang Wang et al.

Summary: This study showed that pseudorabies virus (PRV) infection activates the Wnt/beta-catenin signaling pathway, leading to enhanced virus proliferation and regulation of virus-induced autophagy. Inhibitors of this pathway can reduce PRV titers, while stimulation of the pathway can enhance PRV proliferation. These findings provide potential targets for the development of antiviral agents against PRV.

VETERINARY MICROBIOLOGY (2022)

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Article Medicine, General & Internal

Live-attenuated YF17D-vectored COVID-19 vaccine protects from lethal yellow fever virus infection in mouse and hamster models

Ji Ma et al.

Summary: This study demonstrates that the YF-S0 vaccine can induce strong humoral and cellular immunity against yellow fever virus (YFV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice and hamsters, providing full protection against YFV infection and SARS-CoV-2 strain B1.1.7 (Alpha variant) infection. Importantly, strong pre-existing immunity against the YF17D vector does not interfere with the efficacy of YF-S0 vaccination.

EBIOMEDICINE (2022)

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Review Pharmacology & Pharmacy

Immune Checkpoint Inhibitors for Vaccine Improvements: Current Status and New Approaches

Alexander Batista-Duharte et al.

Summary: The combination of immune checkpoint inhibitors (ICIs) with vaccines has shown promise in improving vaccine immunogenicity and efficacy. Most studies have focused on anti-tumor vaccines combined with monoclonal antibodies targeting specific checkpoints. However, new strategies using ICIs as molecular adjuvants hold great potential for future advances in vaccine research.

PHARMACEUTICS (2022)

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Article Immunology

The Deletion of US3 Gene of Pseudorabies Virus (PRV) ΔgE/TK Strain Induces Increased Immunogenicity in Mice

Meng-Meng Deng et al.

Summary: The study successfully constructed PRV Delta gE/TK/US3 strain by deleting the US3 gene based on PRV Delta gE/TK strain, showing that it is safe for mice, induces higher levels of immune response, and is considered a promising candidate for preventing and controlling the epidemic pseudorabies in China.

VACCINES (2022)

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Review Infectious Diseases

The early-life gut microbiome and vaccine efficacy

Anne Jordan et al.

Summary: This article evaluates the impact of gut microbiota on early life immunity, focusing on the roles of Bifidobacterium and Bacteroides, and discusses their effects on vaccine responses and efficacy in infants. It also presents microbiota-based approaches to enhance vaccine outcomes and explores novel microbe-derived components that could lead to safer, more effective vaccines and adjuvants.

LANCET MICROBE (2022)

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Article Veterinary Sciences

Comprehensive evaluation of the safety and immunogenicity of a gene-deleted variant pseudorabies virus attenuated vaccine

Ling Li et al.

Summary: The study developed and evaluated a gene-deleted variant PRV-attenuated vaccine, PRV GX-Delta TK/IES, which showed complete safety and efficacy in mice and piglet trials. The vaccine provided better immunity and protection compared to a live commercial vaccine, making it a novel candidate for PRV vaccination.

VETERINARY RESEARCH (2022)

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Article Infectious Diseases

Latent pseudorabies virus infection in medulla oblongata from quarantined pigs

Jin-Jin Lu et al.

Summary: The study investigated latent infection with wild-type (wt) PRV and also infection due to the use of live attenuated vaccines on farms. Results showed that PRV DNA fragments were found in the brain tissues of pigs, indicating that live vaccines and wild-type viruses co-exist and may pose potential safety risks to the pig husbandry industry.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

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Article Infectious Diseases

Emergence of a novel pathogenic recombinant virus from Bartha vaccine and variant pseudorabies virus in China

Zongyi Bo et al.

Summary: Two PRV variants, named JSY7 and JSY13 strains, were isolated from a Bartha-K61-vaccinated swine farm. These variants showed different cytopathic effects and plaque sizes, but had the same Aspartate insertions in the gE protein. Genomic analysis clustered JSY7 and JSY13 strains in the same clade with other PRV isolates in China. The study also revealed evidence of genomic recombination between the JSY13 strain and the Bartha and JSY7 strains, highlighting the importance of this process in PRV evolution and virulence.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

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Article Virology

Pseudorabies virus glycoprotein gE suppresses interferon-8 production via CREB-binding protein degradation

Mingqing Lu et al.

Summary: Studies have found that PRV glycoprotein E can inhibit cGAS/STING-mediated IFN-β production by degrading CBP.

VIRUS RESEARCH (2021)

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Review Microbiology

Evasion of I Interferon-Mediated Innate Immunity by Pseudorabies Virus

Rui Zhang et al.

Summary: This review highlights the importance of IFN-I mediated innate immunity in defense against viral infection, focusing on the strategies employed by the alphaherpesvirus Pseudorabies virus (PRV) to counteract IFN-I mediated immunity, particularly through inhibition of IFN-I induced gene transcription via the JAK-STAT pathway. Knowledge gained from PRV contributes to understanding alphaherpesviral immune evasion mechanisms and aids in vaccine development for PRV control.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Microbiology

Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation

Jingying Xie et al.

Summary: The US3 protein of pseudorabies virus has been identified as a crucial viral factor that represses interferon beta expression by targeting interferon regulatory factor 3. This study reveals a novel strategy used by PRV to inhibit IFN-beta production and evade host innate immunity.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Microbiology

Inhibition of the DNA-Sensing pathway by pseudorabies virus UL24 protein via degradation of interferon regulatory factor 7

Xuelan Liu et al.

Summary: The UL24 protein of pseudorabies virus (PRV) interacts with interferon regulatory factor 7 (IRF7) and degrades IRF7 through the proteasome pathway, inhibiting the activation of interferon type I (IFN-?) mediated by cGAS-STING.

VETERINARY MICROBIOLOGY (2021)

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Article Microbiology

Intradermal co-inoculation of codon pair deoptimization (CPD)-attenuated chimeric porcine reproductive and respiratory syndrome virus (PRRSV) with Toll like receptor (TLR) agonists enhanced the protective effects in pigs against heterologous challenge

Changhoon Park et al.

Summary: This study assessed the protective efficacy of vaccination using CPD-attenuated chimeric PRRSV and TLR agonists as adjuvants, finding that intradermal inoculation showed enhanced protective effects, reducing pathological lesions and viral load.

VETERINARY MICROBIOLOGY (2021)

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Article Virology

Pseudorabies virus UL24 antagonizes OASL-mediated antiviral effect

Xiaoyong Chen et al.

Summary: OASL protein regulates PRV proliferation by enhancing RIG-I signaling and suppressing PRV infection, while the PRV UL24 protein impairs RIG-I signaling to inhibit the transcription of interferon and ISGs.

VIRUS RESEARCH (2021)

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Article Virology

Recombinant Pseudorabies Virus with TK/gE Gene Deletion and Flt3L Co-Expression Enhances the Innate and Adaptive Immune Response via Activating Dendritic Cells

Lun Yao et al.

Summary: Emerging pseudorabies virus strains have caused unprecedented outbreaks in swine farms despite previous vaccination, indicating the ineffectiveness of traditional vaccines. The development of a recombinant vaccine has shown enhanced immune responses and potential as a promising candidate for pseudorabies virus vaccination.

VIRUSES-BASEL (2021)

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Article Virology

Host Interferon-Stimulated Gene 20 Inhibits Pseudorabies Virus Proliferation

Xiaoyong Chen et al.

Summary: ISG20 plays a role in suppressing pseudorabies virus replication by enhancing IFN signaling, and its expression is upregulated following PRV infection. The PRV protein UL24 can suppress the transcription of ISG20, thus antagonizing its antiviral effect. These findings provide insights into the interplay between host and PRV.

VIROLOGICA SINICA (2021)

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Article Biochemistry & Molecular Biology

Deacetylation of BmAda3 is required for cell apoptosis caused by Bombyx mori nucleopolyhedrovirus infection

Yajie Zhu et al.

Summary: Silkworm is an important insect model with biological significance and is crucial in sericulture and bioreactors. The Bombyx mori nucleopolyhedrovirus (BmNPV) is a principal pathogen of silkworm. Through studying the acetylation of BmAda3 after BmNPV infection, it was found that acetylation modification affected the stability of P53, promoting cellular apoptosis. The research revealed the regulatory role of BmAda3 in the process of BmNPV infection.

ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY (2021)

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Article Immunology

Pseudorabies Virus DNA Polymerase Processivity Factor UL42 Inhibits Type I IFN Response by Preventing ISGF3-ISRE Interaction

Rui Zhang et al.

Summary: The UL42 proteins of alphaherpesviruses can antagonize the IFN-I-induced JAK-STAT signaling pathway, suppressing the association of ISGF3 and ISRE, thereby contributing to immune evasion. This suggests UL42 as a potential antiviral target.

JOURNAL OF IMMUNOLOGY (2021)

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Article Virology

Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity

Lin Lv et al.

Summary: PRDX1 plays a crucial role in diverse biological processes and positively regulates interferon induction by interacting with TBK1 and IKKε, while being targeted for degradation by PRV UL13 during productive infection. This study reveals a new viral immune evasion strategy and highlights PRDX1 as a potential target for controlling PRV infection.

JOURNAL OF VIROLOGY (2021)

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Article Virology

Pseudorabies Virus Inhibits Type I and Type III Interferon-Induced Signaling via Proteasomal Degradation of Janus Kinases

Yue Yin et al.

Summary: This study reveals a novel evasion mechanism of type I and III interferons by alphaherpesviruses, in which the porcine alphaherpesvirus pseudorabies virus triggers degradation of key Janus kinases Jak1 and Tyk2 to inhibit IFN signaling. This inhibition is not caused by incoming virions and does not depend on viral protein expression or genome replication.

JOURNAL OF VIROLOGY (2021)

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Article Virology

Inhibition of PARP1 Dampens Pseudorabies Virus Infection through DNA Damage-Induced Antiviral Innate Immunity

Guo-Li Li et al.

Summary: Inhibition of PARP1 can induce DNA damage-induced antiviral innate immunity, providing a potential new strategy for preventing Aujeszky's disease in pigs.

JOURNAL OF VIROLOGY (2021)

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Article Virology

Whole-Genome Sequence Analysis of Pseudorabies Virus Clinical Isolates from Pigs in China between 2012 and 2017 in China

Ruiming Hu et al.

Summary: The genomes of novel PRV variants isolated in China from 2012 to 2017 show high relatedness and genetic similarity to classic China strains. Recombination events play a significant role in viral evolution, while most genes are under evolutionary constraint. Positive selection affects 19 amino acid residue sites in 15 genes, leading to the identification of 37 unique mutations distinguishing the novel variants from classic strains.

VIRUSES-BASEL (2021)

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Article Microbiology

RIPK3-Dependent Necroptosis Limits PRV Replication in PK-15 Cells

Hongchao Gou et al.

Summary: The study demonstrated that pseudorabies virus induced RIPK3-dependent necroptosis in PK-15 cells, proposing a mechanism of cell death in PRV infection. Further experiments revealed the involvement of RIPK3 and MLKL in the necrotic cell death induced by PRV, suggesting their potential as therapeutic targets for PRV infection.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Immunology

Herpes Simplex Virus 1 Infection of Neuronal and Non-Neuronal Cells Elicits Specific Innate Immune Responses and Immune Evasion Mechanisms

Amanda L. Verzosa et al.

Summary: This article discusses the transmission and lifecycle of alphaherpesviruses, with a focus on the impact of HSV-1 on host cell innate immune responses. It highlights how HSV-1 suppresses immune responses through various mechanisms, primarily in neuronal and epithelial cells.

FRONTIERS IN IMMUNOLOGY (2021)

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Innate Immune Responses to Herpesvirus Infection

Christine M. O'Connor et al.

Summary: When a host cell is infected by a viral pathogen, the interferon system will initiate attacks, accumulating antiviral proteins and protective cytokines. However, viruses often evolve mechanisms to undermine host immune responses.

CELLS (2021)

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Recombinant pseudorabies virus expressing E2 of classical swine fever virus (CSFV) protects against both virulent pseudorabies virus and CSFV

Wu Tong et al.

ANTIVIRAL RESEARCH (2020)

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Pseudorabies Virus Infection of Epithelial Cells Leads to Persistent but Aberrant Activation of the NF-κB Pathway, Inhibiting Hallmark NF-κB-Induced Proinflammatory Gene Expression

Nicolas Romero et al.

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Efficacy of the Bartha-K61 vaccine and a gE-/gI-/T- prototype vaccine against variant porcine pseudorabies virus (vPRV) in piglets with sublethal challenge of vPRV

Jin Wang et al.

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Construction of a US7/US8/UL23/US3-deleted recombinant pseudorabies virus and evaluation of its pathogenicity in dogs

Hang Yin et al.

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Characterization of a recombinant pseudorabies virus expressing porcine parvovirus VP2 protein and porcine IL-6

Hui-Hua Zheng et al.

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Pseudorabies Virus UL24 Abrogates Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Degrading P65

Tong-Yun Wang et al.

VIRUSES-BASEL (2020)

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Article Biochemistry & Molecular Biology

Host BAG3 Is Degraded by Pseudorabies Virus pUL56 C-Terminal 181L-185L and Plays a Negative Regulation Role during Viral Lytic Infection

Chuang Lyu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Microbiology

Glycoproteins C and D of PRV Strain HB1201 Contribute Individually to the Escape From Bartha-K61 Vaccine-Induced Immunity

Jianle Ren et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Biochemical Research Methods

Construction and immunogenicity of a gE/gI/TK-deleted PRV based on porcine pseudorabies virus variant

Yu Zhao et al.

MOLECULAR AND CELLULAR PROBES (2020)

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Review Microbiology

The Neuropathic Itch Caused by Pseudorabies Virus

Kathlyn Laval et al.

PATHOGENS (2020)

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Review Microbiology

Aujeszky's Disease and the Development of the Marker/DIVA Vaccination Concept

Thomas C. Mettenleiter

PATHOGENS (2020)

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Review Microbiology

Comparative Pathology of Pseudorabies in Different Naturally and Experimentally Infected Species-A Review

Julia Sehl et al.

PATHOGENS (2020)

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Inactivating Three Interferon Antagonists Attenuates Pathogenesis of an Enteric Coronavirus

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JOURNAL OF VIROLOGY (2020)

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Rab9 defense against white spot syndrome virus by participation in autophagy in Marsupenaeus japonicas

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FISH & SHELLFISH IMMUNOLOGY (2020)

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Evidence for interspecies transmission route of pseudorabies virus via virally contaminated fomites

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VETERINARY MICROBIOLOGY (2020)

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Review Microbiology

The Attenuated Pseudorabies Virus Vaccine Strain Bartha K61: A Brief Review on the Knowledge Gathered during 60 Years of Research

Jonas L. Delva et al.

PATHOGENS (2020)

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PRV-encoded UL13 protein kinase acts as an antagonist of innate immunity by targeting IRF3-signaling pathways

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VETERINARY MICROBIOLOGY (2020)

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Article Veterinary Sciences

PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3

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VETERINARY RESEARCH (2020)

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Coinfections and their molecular consequences in the porcine respiratory tract

Georges Saade et al.

VETERINARY RESEARCH (2020)

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Review Immunology

RIG-I-like receptors: their regulation and roles in RNA sensing

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NATURE REVIEWS IMMUNOLOGY (2020)

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Article Infectious Diseases

Characterization of a moderately pathogenic pseudorabies virus variant isolated in China, 2014

Mingming Zhou et al.

INFECTION GENETICS AND EVOLUTION (2019)

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Article Microbiology

Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3

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PLOS PATHOGENS (2019)

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DNA sensing by the cGAS-STING pathway in health and disease

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NATURE REVIEWS GENETICS (2019)

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Commercial vaccine against pseudorabies virus: A hidden health risk for dogs

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VETERINARY MICROBIOLOGY (2019)

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Article Virology

Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019

Xiaofeng Zhai et al.

VIROLOGICA SINICA (2019)

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Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines

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MBIO (2019)

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Alphaherpesvirus infection of mice primes PNS neurons to an inflammatory state regulated by TLR2 and type I IFN signaling

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PLOS PATHOGENS (2019)

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Annual Review of Animal Biosciences (2019)

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Article Immunology

Interspecies Transmission, Genetic Diversity, and Evolutionary Dynamics of Pseudorabies Virus

Wanting He et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

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Editorial Material Immunology

Pseudorabies virus: a neglected zoonotic pathogen in humans?

Gary Wong et al.

EMERGING MICROBES & INFECTIONS (2019)

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Apoptosis Induction by Pseudorabies Virus via Oxidative Stress and Subsequent DNA Damage Signaling

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INTERVIROLOGY (2019)

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Review Pharmacology & Pharmacy

Molecular adjuvants that modulate regulatory T cell function in vaccination: A critical appraisal

Alexander Batista-Duharte et al.

PHARMACOLOGICAL RESEARCH (2018)

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Deletion of pseudorabies virus US2 gene enhances viral titers in a porcine cerebral cortex primary culture system

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VIRUS GENES (2018)

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Article Virology

Pseudorabies virus induces autophagy to enhance viral replication in mouse neuro-2a cells in vitro

Changmeng Xu et al.

VIRUS RESEARCH (2018)

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Safety and immunogenicity of an attenuated Chinese pseudorabies variant by dual deletion of TK&gE genes

Jichun Wang et al.

BMC VETERINARY RESEARCH (2018)

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Global trends in infectious diseases of swine

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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The independence of and associations among apoptosis, autophagy, and necrosis

Qi Chen et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2018)

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The Pseudorabies Virus Glycoprotein gE/gI Complex Suppresses Type I Interferon Production by Plasmacytoid Dendritic Cells

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JOURNAL OF VIROLOGY (2017)

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Article Virology

Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response

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JOURNAL OF VIROLOGY (2017)

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Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Microbiology

Vaccines against pseudorabies virus (PrV)

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VETERINARY MICROBIOLOGY (2017)

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A live gI/gE-deleted pseudorabies virus (PRV) protects weaned piglets against lethal variant PRV challenge

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VIRUS GENES (2017)

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Pseudorabies virus infection inhibits autophagy in permissive cells in vitro

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SCIENTIFIC REPORTS (2017)

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Ten Strategies of Interferon Evasion by Viruses

Adolfo Garcia-Sastre

CELL HOST & MICROBE (2017)

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A live, attenuated pseudorabies virus strain JS-2012 deleted for gE/gI protects against both classical and emerging strains

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ANTIVIRAL RESEARCH (2016)

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Safety and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant expressing the E2 protein of classical swine fever virus in pigs

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IMMUNOLOGY LETTERS (2016)

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Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing

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NATURE IMMUNOLOGY (2016)

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Pathogenicity and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant in susceptible animals

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VETERINARY MICROBIOLOGY (2016)

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Review Microbiology

Control of swine pseudorabies in China: Opportunities and limitations

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VETERINARY MICROBIOLOGY (2016)

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Genomic analyses reveal that partial sequence of an earlier pseudorabies virus in China is originated from a Bartha-vaccine-like strain

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VIROLOGY (2016)

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Pseudorabies virus glycoprotein gE triggers ERK1/2 phosphorylation and degradation of the pro-apoptotic protein Bim in epithelial cells

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Herpes Simplex Virus Suppresses Necroptosis in Human Cells

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Outbreak of variant pseudorabies virus in Bartha-K61-vaccinated piglets in central Shandong Province, China

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Phagocytosis of apoptotic cells in homeostasis

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Novel pseudorabies virus variant with defects in TK, gE and gI protects growing pigs against lethal challenge

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Emergence of a Pseudorabies virus variant with increased virulence to piglets

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Construction and immune efficacy of recombinant pseudorabies virus expressing PrM-E proteins of Japanese encephalitis virus genotype I

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Molecular cloning and functional characterization of porcine DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41)

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Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

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A Next-generation Genetically Attenuated Plasmodium falciparum Parasite Created by Triple Gene Deletion

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A novel gE-deleted pseudorabies virus (PRV) provides rapid and complete protection from lethal challenge with the PRV variant emerging in Bartha-K61-vaccinated swine population in China

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RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

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Pathogenic Pseudorabies Virus, China, 2012

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EMERGING INFECTIOUS DISEASES (2014)

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Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

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The Us2 Gene Product of Herpes Simplex Virus 2 Is a Membrane-Associated Ubiquitin-Interacting Protein

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Suppression of apoptosis by pseudorabies virus Us3 protein kinase through the activation of P13-K/Akt and NF-κB pathways

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Attenuated live vaccine (Bartha-K16) caused pseudorabies (Aujeszky's disease) in sheep

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DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

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Kinesin-3 Mediates Axonal Sorting and Directional Transport of Alphaherpesvirus Particles in Neurons

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Autophagy in immunity and cell-autonomous defense against intracellular microbes

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Recombinant pseudorabies virus expressing P12A and 3C of FMDV can partially protect piglets against FMDV challenge

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A novel recombinant pseudorabies virus expressing parvovirus VP2 gene: Immunogenicity and protective efficacy in swine

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Molecular cloning and functional characterization of porcine DNA-dependent activator of IFN-regulatory factors (DAI)

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Molecular mechanisms of necroptosis: an ordered cellular explosion

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Attenuation of V- or C-defective measles viruses: Infection control by the inflammatory and interferon responses of rhesus monkeys

Patricia Devaux et al.

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Induction of protective immunity in swine by immunization with live attenuated recombinant pseudorabies virus expressing the capsid precursor encoding regions of foot-and-mouth disease virus

Xiangmin Li et al.

VACCINE (2008)

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Colony-stimulating factors in inflammation and autoimmunity

John A. Hamilton

NATURE REVIEWS IMMUNOLOGY (2008)

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Immunization of primates with a newcastle disease virus-vectored vaccine via the respiratory tract induces a high titer of serum neutralizing antibodies against highly pathogenic avian influenza virus

Joshua M. DiNapoli et al.

JOURNAL OF VIROLOGY (2007)

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Unveiling the roles of autophagy in innate and adaptive immunity

Beth Levine et al.

NATURE REVIEWS IMMUNOLOGY (2007)

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Pseudorabies virus EPO protein counteracts an interferon-induced antiviral state in a species-specific manner

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JOURNAL OF VIROLOGY (2006)

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Suppression of the interferon-mediated innate immune response by pseudorabies virus

Alla Brukman et al.

JOURNAL OF VIROLOGY (2006)

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Pathogen recognition and innate immunity

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CELL (2006)

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Mycobacterium tuberculosis heat shock proteins use diverse toll-like receptor pathways to activate pro-inflammatory signals

Y Bulut et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Autophagy in metazoans: Cell survival in the land of plenty

JJ Lum et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

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Molecular biololgy of pseudorabies virus: Impact on neurovirology and veterinary medicine

LE Pomeranz et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2005)

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New embo member's review -: NF-κB and virus infection:: who controls whom

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EMBO JOURNAL (2003)

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NF-κB regulation in the immune system

QT Li et al.

NATURE REVIEWS IMMUNOLOGY (2002)

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Granulocyte-macrophage colony-stimulating factor expressed by recombinant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells

A Bukreyev et al.

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A conserved α-herpesvirus protein necessary for axonal localization of viral membrane proteins

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Four deaths and a funeral:: From caspases to alternative mechanisms

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)

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Induction and inhibition of apoptosis by pseudorabies virus in the trigeminal ganglion during acute infection of swine

N Aleman et al.

JOURNAL OF VIROLOGY (2001)

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Physiological significance of apoptosis in animal virus infection

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MICROBES AND INFECTION (2000)

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Pseudorabies virus induces apoptosis in tissue culture cells

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ARCHIVES OF VIROLOGY (2000)

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