4.6 Review

Bacteria and macrophages in the tumor microenvironment

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Summary: The interaction of tumour-associated macrophages (TAMs) with cancer and stromal cells in the tumour microenvironment enables and sustains most of the hallmarks of cancer. The authors of this Review examine the diversity of TAMs in various cancer indications, which is being revisited with the advent of single-cell technologies, and discuss the functional roles of different TAM states, the prognostic and predictive value of TAM-related signatures as well as approaches involving TAMs that are currently being or will soon be tested in clinical trials.

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Summary: This article reviews the characteristics of tumor-associated macrophages (TAMs) and discusses the mechanisms that contribute to their pathological adaptations to the tumor microenvironment. TAMs play a crucial role in the tumor microenvironment and are closely associated with cancer progression.

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Propionibacterium acnes overabundance in gastric cancer promote M2 polarization of macrophages via a TLR4/PI3K/Akt signaling

Qing Li et al.

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Fusobacterium nucleatum Facilitates M2 Macrophage Polarization and Colorectal Carcinoma Progression by Activating TLR4/NF-κB/S100A9 Cascade

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