Yeast oral vaccines against infectious diseases

Article Psychology, Clinical

Injection fears and COVID-19 vaccine hesitancy

Daniel Freeman et al.

Summary: Blood-injection-injury fears contribute to approximately 10% of COVID-19 vaccine hesitancy in the UK adult population. Addressing these fears can improve the effectiveness of vaccination programs.

PSYCHOLOGICAL MEDICINE (2023)

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Article Immunology

A Novel Whole Yeast-Based Subunit Oral Vaccine Against Eimeria tenella in Chickens

Francesca Soutter et al.

Summary: A cheap and easy-to-produce oral vaccine has been developed using Saccharomyces cerevisiae yeast expressing Eimeria tenella antigens. The vaccine effectively reduces the replication of Eimeria tenella and improves the growth of chickens, making it an important tool for controlling coccidiosis in chickens, particularly in low- and middle-income countries.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Microbiology

Oral SARS-CoV-2 Spike Protein Recombinant Yeast Candidate Prompts Specific Antibody and Gut Microbiota Reconstruction in Mice

Lilin Zhang et al.

Summary: A recent study found that patients with COVID-19 have gastrointestinal symptoms and dysbiosis of intestinal flora. Researchers developed an oral candidate made from yeast-derived proteins, which showed improved immune function without significant side effects in mouse studies. The study also found that mice given the oral treatment had detectable antibodies against SARS-CoV-2 and a more diverse microbiota compared to the control group. The study suggests that this yeast-based approach could be a promising strategy for non-invasive immunization and restoring gut flora.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Immunology

Oral Vaccination With Recombinant Pichia pastoris Expressing Iridovirus Major Capsid Protein Elicits Protective Immunity in Largemouth Bass (Micropterus salmoides)

Jia-Yun Yao et al.

Summary: In this study, a recombinant Pichia pastoris expressing LMBV major capsid protein (MCPD) was constructed and used to orally immunize largemouth bass. The results showed that mucosal immune response mediated by immunoglobulins (Igs) was induced after oral immunization, and the pathological damage caused by LMBV was alleviated.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Gastroenterology & Hepatology

Mucus, commensals, and the immune system

Qing Zhao et al.

Summary: This brief review discusses recent findings on the host-microbiota mutualism at the colonic mucosal border. It highlights the interaction between the immune system and mucus-associated bacteria, as well as the potential significance of this knowledge for understanding chronic intestinal inflammation.

GUT MICROBES (2022)

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Review Biotechnology & Applied Microbiology

Saccharomyces cerevisiae cell surface display technology: Strategies for improvement and applications

Chenmeng Zhang et al.

Summary: Microbial cell surface display technology is a powerful platform for engineering proteins/peptides with improved properties. Saccharomyces cerevisiae is an ideal cell factory for this technology due to its large cell size, Generally Regarded As Safe (GRAS) status, and post-translational processing capabilities. This technology has various applications in industrial processes, including biofuels and chemical production, environmental pollution treatment, and immunization processes.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Microbiology

Oral immunization of recombinant Saccharomyces cerevisiae expressing fiber-2 of fowl adenovirus serotype 4 induces protective immunity against homologous infection

Hongwei Cao et al.

Summary: This study explores the potential for oral immunization of recombinant Saccharomyces cerevisiae expressing Fiber-2 of fowl adenovirus serotype 4 as a subunit vaccine. The results show that oral administration of the recombinant yeast can stimulate immune response, enhance antiviral activity, improve gut microbiota, and provide protection against FAdV-4 infection. Combining the yeast with an inactivated vaccine has a synergistic effect on immune response.

VETERINARY MICROBIOLOGY (2022)

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Article Immunology

Gut mucosal immune responses and protective efficacy of oral yeast Cyprinid herpesvirus 2 (CyHV-2) vaccine in Carassius auratus gibelio

Zhao-Ran Dong et al.

Summary: This study developed an oral vaccine against CyHV-2 using yeast cell surface display technology and demonstrated its protective efficacy in gibel carp. The vaccine group showed higher activities of immune-related enzymes and gene expression, and strong innate and adaptive immune responses were elicited in mucosal and systemic tissues after oral vaccination with the yeast vaccine.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Pharmacology & Pharmacy

Oral Biologic Delivery: Advances Toward Oral Subunit, DNA, and mRNA Vaccines and the Potential for Mass Vaccination During Pandemics

Jacob William Coffey et al.

Summary: Oral vaccination allows for pain-free and self-administered vaccine delivery, inducing both systemic and mucosal immune responses to protect against infection and minimize disease spread. Various challenges in the gastrointestinal tract are being addressed to improve oral vaccine targeting and delivery, with focus on recent advances in oral biologic delivery for future vaccine administration platforms.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)

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Article Virology

Porcine Immunoglobulin Fc Fused P30/P54 Protein of African Swine Fever Virus Displaying on Surface of S. cerevisiae Elicit Strong Antibody Production in Swine

Chen Chen et al.

Summary: A recombinant Saccharomyces cerevisiae (S. cerevisiae) vaccine was constructed to control African swine fever virus (ASFV) infection, which induced specific antibody production in pigs, enhanced mucosal immunity, and improved cell adhesion and phagocytosis capabilities.

VIROLOGICA SINICA (2021)

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Article Gastroenterology & Hepatology

Immune evaluation of a Saccharomyces cerevisiae-based oral vaccine against Helicobacter pylori in mice

Qianhong Cen et al.

Summary: The study successfully developed Saccharomyces cerevisiae-based oral vaccines against H. pylori, which induced significant humoral and mucosal immune responses in mice, and effectively reduced bacterial loads after H. pylori infection. This suggests that S. cerevisiae-based platforms may serve as promising bacterial oral vaccine candidates in the future.

HELICOBACTER (2021)

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Review Immunology

Recent strategies driving oral biologic administration

Badriyah Shadid Alotaibi et al.

Summary: Oral vaccination offers high patient compliance, noninvasiveness, and self-administration, with the potential to elicit mucosal and systemic immune responses for protection against mucosal surface infections. The focus is on targeting different mucosal inductive sites in the gastrointestinal tract to limit disease spread. Development of biologic delivery through the oral route is considered for future oral vaccination strategies.

EXPERT REVIEW OF VACCINES (2021)

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Article Biotechnology & Applied Microbiology

Shrimp protected from a virus by feed containing yeast with a surface-displayed viral binding protein

Vorawit Ananphongmanee et al.

Summary: The expression of the viral binding protein PmRab7 on the surface of recombinant Pichia pastoris cells showed potential as an oral prophylactic against white spot syndrome virus (WSSV) in shrimp. The cells significantly lowered WSSV replication levels and increased shrimp survival rates, indicating promise for future development in shrimp aquaculture.

JOURNAL OF BIOTECHNOLOGY (2021)

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Editorial Material Biotechnology & Applied Microbiology

Call for More Effective Regulation of Clinical Trials with Advanced Therapy Medicinal Products Consisting of or Containing Genetically Modified Organisms in the European Union

Stuart Beattie

Summary: Compliance with GMO requirements for ATMPs in EU Member States varies significantly, leading to delays in clinical trials and making it difficult to conduct multicenter trials. The European Commission should consider simplifying regulations to improve access to gene therapies for European patients.

HUMAN GENE THERAPY (2021)

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Article Biotechnology & Applied Microbiology

Immune response induced by oral administration with a Saccharomyces cerevisiae-based SARS-CoV-2 vaccine in mice

Tong Gao et al.

Summary: The global COVID-19 pandemic has highlighted the urgent need for vaccines, with several candidates under development. A Saccharomyces cerevisiae-based vaccine against SARS-CoV-2 showed significant immune responses in mice, indicating the potential for use as a universal technology platform for developing other oral viral or bacterial vaccines.

MICROBIAL CELL FACTORIES (2021)

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Article Multidisciplinary Sciences

High immune efficacy against different avian influenza H5N1 viruses due to oral administration of a Saccharomyces cerevisiae-based vaccine in chickens

Han Lei et al.

Summary: Oral vaccination with EBY100/pYD1-HA in the chicken model can induce robust immune responses and provide protection against challenges with homologous and heterologous H5N1 viruses, suggesting it as a promising candidate for H5N1 oral vaccine to be used in poultry during HPAI A (H5N1) outbreaks.

SCIENTIFIC REPORTS (2021)

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Article Virology

Oral administration of Saccharomyces cerevisiae displaying VP28-VP24 confers protection against white spot syndrome virus in shrimp

Han Lei et al.

Summary: By utilizing a Saccharomyces cerevisiae surface display system, a potential vaccine candidate against White spot syndrome virus (WSSV) was developed and shown to induce significant immune-related enzyme activities in shrimp when orally administered. The oral vaccine conferred 100% protection and reduced viral load in shrimp, highlighting its potential as an efficient control strategy against WSSV infection in shrimp aquaculture.

VIRUS RESEARCH (2021)

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Article Immunology

Development of a Potential Yeast-Based Vaccine Platform for Theileria parva Infection in Cattle

Shan Goh et al.

Summary: The study aimed to develop an affordable and easy-to-administer subunit vaccine for East Coast Fever (ECF) using yeast as an expression platform. Results showed that recombinant yeast expressing T. parva antigens could induce immune responses and specific antibodies in mice, suggesting a promising vaccination platform for sub-Saharan Africa. Further evaluation of antigen-specific cellular immune responses, especially cytotoxic CD8(+) T cell immunity in cattle, will contribute to the development of a yeast-based vaccine for ECF.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Fisheries

Protective immunity against CyHV-3 infection via different prime-boost vaccination regimens using CyHV-3 ORF131-based DNA/protein subunit vaccines in carp Cyprinus carpio var. Jian

Zhenxing Liu et al.

FISH & SHELLFISH IMMUNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Trehalose Protects the Probiotic Yeast Saccharomyces boulardii against Oxidative Stress-Induced Cell Death

Ji Eun Moon et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Yeast display platform technology to prepare oral vaccine against lethal H7N9 virus challenge in mice

Han Lei et al.

MICROBIAL CELL FACTORIES (2020)

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Article Veterinary Sciences

Oral vaccination using Artemia coated with recombinant Saccharomyces cerevisiae expressing cyprinid herpesvirus-3 envelope antigen induces protective immunity in common carp (Cyprinus carpio var. Jian) larvae

Yanping Ma et al.

RESEARCH IN VETERINARY SCIENCE (2020)

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Review Microbiology

Saccharomyces boulardii: What Makes It Tick as Successful Probiotic?

Pedro Pais et al.

JOURNAL OF FUNGI (2020)

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Article Fisheries

Pichia pastoris yeast as a vehicle for oral vaccination of larval and adult teleosts

Carmen W. E. Embregts et al.

FISH & SHELLFISH IMMUNOLOGY (2019)

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Review Immunology

Clinical trials with GMO-containing vaccines in Europe: Status and regulatory framework

Florence Kauffmann et al.

VACCINE (2019)

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Article Biotechnology & Applied Microbiology

Comparative immunogenicity of preparations of yeast-derived dengue oral vaccine candidate

Jyotiranjan Bal et al.

MICROBIAL CELL FACTORIES (2018)

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Article Immunology

Protective immune response against Toxoplasma gondii elicited by a novel yeast-based vaccine with microneme protein 16

Long-jiang Wang et al.

VACCINE (2018)

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Article Microbiology

Oral Administration of Recombinant Saccharomyces boulardii Expressing Ovalbumin-CPE Fusion Protein Induces Antibody Response in Mice

Ghasem Bagherpour et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Article Biotechnology & Applied Microbiology

Evaluation of cell-surface displayed synthetic consensus dengue EDIII cells as a potent oral vaccine candidate

Jyotiranjan Bal et al.

MICROBIAL CELL FACTORIES (2018)

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Article Biochemistry & Molecular Biology

Preliminary study of an oral vaccine against infectious hematopoietic necrosis virus using improved yeast surface display technology

Jing-Zhuang Zhao et al.

MOLECULAR IMMUNOLOGY (2017)

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Article Microbiology

Oral vaccination through voluntary consumption of the convict grouper Epinephelus septemfasciatus with yeast producing the capsid protein of red-spotted grouper nervous necrosis virus

Seo Young Cho et al.

VETERINARY MICROBIOLOGY (2017)

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Review Pharmacology & Pharmacy

Current state and challenges in developing oral vaccines

Julia E. Vela Ramirez et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

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Article Chemistry, Multidisciplinary

Surface-modified yeast cells: A novel eukaryotic carrier for oral application

Elisabeth E. Kenngott et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Multidisciplinary Sciences

Characterization of the Probiotic Yeast Saccharomyces boulardii in the Healthy Mucosal Immune System

Lauren E. Hudson et al.

PLOS ONE (2016)

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Article Immunology

Heat killed Saccharomyces cerevisiae as an adjuvant for the induction of vaccine-mediated immunity against infection with Mycobacterium tuberculosis

Ajay Grover et al.

VACCINE (2016)

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Article Immunology

Human Enterovirus 71 Protein Displayed on the Surface of Saccharomyces cerevisiae as an Oral Vaccine

Congdang Zhang et al.

VIRAL IMMUNOLOGY (2016)

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Article Immunology

Orally Administrated Whole Yeast Vaccine Against Porcine Epidemic Diarrhea Virus Induced High Levels of IgA Response in Mice and Piglets

Xinglong Wang et al.

VIRAL IMMUNOLOGY (2016)

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Article Parasitology

Evaluation of immune protective efficacies of Eimeria tenella EtMic1 polypeptides with different domain recombination displayed on yeast surface

Peipei Chen et al.

EXPERIMENTAL PARASITOLOGY (2015)

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Article Immunology

Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo

Robert Patterson et al.

VACCINE (2015)

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Article Multidisciplinary Sciences

Yeast Surface Display of Two Proteins Previously Shown to Be Protective Against White Spot Syndrome Virus (WSSV) in Shrimp

Vorawit Ananphongmanee et al.

PLOS ONE (2015)

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Article Veterinary Sciences

Recombinant Kluyveromyces lactis expressing highly pathogenic porcine reproductive and respiratory syndrome virus GP5 elicits mucosal and cell-mediated immune responses in mice

Haiyan Zhao et al.

JOURNAL OF VETERINARY SCIENCE (2014)

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Article Biotechnology & Applied Microbiology

Oral immunization with whole yeast producing viral capsid antigen provokes a stronger humoral immune response than purified viral capsid antigen

H. J. Kim et al.

LETTERS IN APPLIED MICROBIOLOGY (2014)

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Article Multidisciplinary Sciences

Functional Heterologous Protein Expression by Genetically Engineered Probiotic Yeast Saccharomyces boulardii

Lauren E. Hudson et al.

PLOS ONE (2014)

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Article Immunology

Display of Eimeria tenella EtMic2 protein on the surface of Saccharomyces cerevisiae as a potential oral vaccine against chicken coccidiosis

Hui Sun et al.

VACCINE (2014)

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Article Fisheries

Codon-optimized expression of fish iridovirus capsid protein in yeast and its application as an oral vaccine candidate

J. Y. Seo et al.

JOURNAL OF FISH DISEASES (2013)

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Article Multidisciplinary Sciences

Protective Oral Vaccination against Infectious bursal disease virus Using the Major Viral Antigenic Protein VP2 Produced in Pichia pastoris

Omid Taghavian et al.

PLOS ONE (2013)

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Article Immunology

Induction of protective immune responses against challenge of Actinobacillus pleuropneumoniae by oral administration with Saccharomyces cerevisiae expressing Apx toxins in pigs

Min-Kyoung Shin et al.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2013)

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Article Immunology

An oral vaccine against candidiasis generated by a yeast molecular display system

Seiji Shibasaki et al.

PATHOGENS AND DISEASE (2013)

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Article Multidisciplinary Sciences

Protective Vaccination against Infectious Bursal Disease Virus with Whole Recombinant Kluyveromyces lactis Yeast Expressing the Viral VP2 Subunit

Marina Arnold et al.

PLOS ONE (2012)

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Editorial Material Biology

Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine

Myron M. Levine

BMC BIOLOGY (2010)

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Article Biochemistry & Molecular Biology

Antiapoptotic role of S-adenosyl-L-methionine against hydrochloric acid induced cell death in Saccharomyces cerevisiae

Dipankar Malakar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2008)

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Article Oncology

Vaccination with a recombinant Saccharomyces cerevisiae expressing a tumor antigen breaks immune tolerance and elicits therapeutic antitumor responses

Elizabeth K. Wansley et al.

CLINICAL CANCER RESEARCH (2008)

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Article Immunology

Oral vaccine delivery: can it protect against non-mucosal pathogens?

Lina Wang et al.

EXPERT REVIEW OF VACCINES (2008)

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Article Oncology

Inducing efficient cross-priming using antigen-coated yeast particles

Shanshan W. Howland et al.

JOURNAL OF IMMUNOTHERAPY (2008)

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Article Immunology

Recombinant Saccharomyces cerevisiae (yeast-CEA) as a potent activator of murine dendritic cells

Michael B. Bernstein et al.

VACCINE (2008)

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Article Biotechnology & Applied Microbiology

Genotypic and physiological characterization of Saccharomyces boulardii, the probiotic strain of Saccharomyces cerevisiaev

Laura Edwards-Ingram et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)

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Article Immunology

Extensive MHC class I-restricted CD8 T lymphocyte responses against various yeast genera in humans

T Heintel et al.

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY (2003)

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Article Biochemistry & Molecular Biology

Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity

AC Stubbs et al.

NATURE MEDICINE (2001)

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Yeast oral vaccines against infectious diseases

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