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Antimicrobial resistance and mechanisms of epigenetic regulation

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)

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The DNA Phosphorothioation Restriction-Modification System Influences the Antimicrobial Resistance of Pathogenic Bacteria

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Summary: This study demonstrated the effect of DNA PT modification-based restriction-modification (R-M) systems on horizontal gene transfer (HGT) of antimicrobial resistance (AMR) genes in pathogenic bacteria. The presence of PT R-M effectively reduced the distribution of HGT-derived AMR genes in the genome and suppressed HGT frequency. There is no coevolution between PT R-M clusters and bacterial core genes.

MICROBIOLOGY SPECTRUM (2023)

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Review Microbiology

Small RNAs, Large Networks: Posttranscriptional Regulons in Gram-Negative Bacteria

Kai Papenfort et al.

Summary: Small regulatory RNAs (sRNAs) play a key role in posttranscriptional gene control in bacteria, often modulating the expression of multiple genes. The regulatory properties of sRNAs and their interplay with transcription factors shape the output of regulatory networks. Additionally, sRNA activity can be antagonized by base-pairing with sponge RNAs, adding complexity to these networks.

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Article Microbiology

Synergistic Effect of SOS Response and GATC Methylome Suppression on Antibiotic Stress Survival in Escherichia coli

S. Diaz-Diaz et al.

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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2023)

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Article Biochemistry & Molecular Biology

FinO/ProQ-family proteins: an evolutionary perspective

Zhen Liao et al.

BIOSCIENCE REPORTS (2023)

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Article Biochemistry & Molecular Biology

High-throughput screening and molecular dynamics simulations of natural products targeting LuxS/AI-2 system as a novel antibacterial strategy for antibiotic resistance in Helicobacter pylori

Avinash Karkada Ashok et al.

Summary: The study aims to explore effective and safer therapeutic choices than current methods for treating Helicobacter pylori (H. pylori)-related gastrointestinal disease. Using molecular docking and molecular dynamics simulation, the affinity of numerous natural chemicals for the LuxS protein of H. pylori was evaluated. Glucoraphanin, catechin gallate, and epigallocatechin gallate were found to have the highest binding energy and stable docking postures with LuxS. Epigallocatechin gallate showed the highest binding free energy and promising antibacterial qualities according to ADMET analysis.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2023)

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Article Biochemistry & Molecular Biology

Small RNAs and Hfq capture unfolded RNA target sites during transcription

Margaret L. Rodgers et al.

Summary: sRNPs play key roles in guiding the folding, modification, and splicing of nascent precursor RNAs during transcription. However, the rapid co-transcriptional folding of RNA can hinder the recognition and regulation of sRNP binding sites. In this study, the binding of Hfq•DsrA sRNPs to rpoS transcripts was examined using the single-molecule co-localization co-transcriptional assembly (smCoCoA) technique. It was found that Hfq•DsrA samples the mRNA before the transcription of the target site, preparing it for base pairing with DsrA. Furthermore, it was observed that Hfq•DsrA often binds to the mRNA close to RNA polymerase (RNAP) during the synthesis of the target site. This suggests that targeting transcripts near RNAP allows sRNPs to capture the site before the RNA folds, providing a kinetic advantage in recognition and regulation.

MOLECULAR CELL (2023)

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Article Microbiology

Involvement of RNA chaperone hfq in the regulation of antibiotic resistance and virulence in Shigella sonnei

Ya Wang et al.

Summary: The study investigated the functional roles of Hfq in Shigella sonnei by constructing an hfq deletion mutant. The results showed that the hfq deletion mutant was more sensitive to antibiotics and had impaired virulence. Transcriptome analyses supported the phenotype of the hfq mutant and predicted eleven novel Hfq-dependent sRNAs potentially involved in the regulation of antibiotic resistance and/or virulence in S. sonnei.

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Antibacterial Activity of Epigallocatechin Gallate (EGCG) against Shigella flexneri

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International Journal of Environmental Research and Public Health (2023)

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Article Biotechnology & Applied Microbiology

The posttranscriptional regulator CsrA affects multidrug resistance and biocontrol activity in Lysobacter enzymogenes

Menghao Yu et al.

Summary: Deletion of the CsrA gene in Lysobacter enzymogenes strain C3 resulted in slow growth and reduced resistance to multiple antibiotics. The deletion also affected its ability to inhibit hypha growth and its extracellular enzyme activities. Additionally, two putative small noncoding regulatory RNAs (sRNAs), csrB and csrC, were identified in the genome of LeC3. Double deletion of csrB and csrC increased resistance to antibiotics but did not affect biocontrol activity.

JOURNAL OF APPLIED MICROBIOLOGY (2023)

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Review Microbiology

The roles of nucleoid-associated proteins and topoisomerases in chromosome structure, strand segregation, and the generation of phenotypic heterogeneity in bacteria

Vic Norris et al.

Summary: The segregation of hyperstructures and the gradient of supercoiling along the chromosome can explain the generation of selectable phenotypic ranges in bacteria.

FEMS MICROBIOLOGY REVIEWS (2023)

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Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J. L. Murray et al.

Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.

LANCET (2022)

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Article Biotechnology & Applied Microbiology

Mutants lacking global regulators, fis and arcA, in Escherichia coli enhanced growth fitness under acetate metabolism by pathway reprogramming

Shikha Jindal et al.

Summary: Global regulatory transcription factors play a significant role in controlling microbial metabolism. This study investigates the effect of acetate on microbial metabolism under disrupted global regulators and reveals the metabolic reprogramming of mutant strains, resulting in faster growth rates and better carbon usage. These findings have important implications for the biosynthesis of isoprenoids, biofuels, vitamins, and pharmaceutical products using mutant strains.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2022)

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Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA

Jujun Zhou et al.

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EPIGENETICS (2022)

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Drug Resistance and Epigenetic Modulatory Potential of Epigallocatechin-3-Gallate Against Staphylococcus aureus

Ana Sofia Zeferino et al.

Summary: This study evaluates the potential of epigallocatechin-3-gallate (EGCG) as an antimicrobial agent against methicillin-resistant Staphylococcus aureus (MRSA) and reports its synergistic effects and association with altered expression of epigenetic and drug response modulators genes. The findings suggest that EGCG could be a promising treatment or therapeutic adjuvant against antibiotic-resistant microorganisms.

CURRENT MICROBIOLOGY (2022)

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Article Microbiology

The Role and Targets of the RNA-Binding Protein ProQ in the Gram-Negative Bacterial Pathogen Pasteurella multocida

Emily L. Gulliver et al.

Summary: Regulation in P. multocida involving the RNA-binding protein Hfq is required for hyaluronic acid capsule production and virulence. This study further expands our understanding of riboregulation by examining the role of a second RNA-binding protein, ProQ, in transcript regulation and abundance in P. multocida. The analyses demonstrated that ProQ binds to specific RNA targets and stabilizes sRNAs and transfer RNAs in P. multocida.

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50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

Zane T. Laughlin et al.

Summary: Changes in bacterial ribosomal RNA methylation can have significant impact on antibiotic activity and drug resistance. This study investigates the role of the methyltransferase TlyA in antibiotic resistance in Mycobacterium tuberculosis. The researchers report the structure of a complex between the mycobacterial 50S subunit and TlyA, revealing critical interactions involved in substrate recognition and positioning of the active site. They also find that TlyA interacts with the 30S subunit using the same interaction surface but with different dependence on conserved residues.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Bacteriophage protein Gp46 is a cross-species inhibitor of nucleoid-associated HU proteins

Peipei Zhang et al.

Summary: The HU protein is crucial for bacterial cell viability and serves as an antibiotic target. This study reveals that Gp46 from bacteriophage SPO1 can inhibit HU, leading to growth defects in bacteria. Through structural analysis, it is found that Gp46 occupies the DNA binding site of HU, thus preventing DNA binding. This discovery provides valuable insights into developing antibacterial and anti-malaria drugs.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Involvement of the DNA Phosphorothioation System in TorR Binding and Anaerobic TMAO Respiration in Salmonella enterica

You Tang et al.

Summary: Since the discovery of DNA phosphorothioate (PT) modification systems in Streptomyces lividans in the 1980s, research on PT systems has yielded important findings. However, the functions of PT systems, particularly in genetic regulation, are largely unknown. This study reveals that the PT system in Salmonella enterica serovar Cerro 87 is involved in the transcriptional regulation of the torCAD operon, shedding light on a new function of PT systems.

MBIO (2022)

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The Fis Nucleoid Protein Negatively Regulates the Phase Variation fimS Switch of the Type 1 Pilus Operon in Enteropathogenic Escherichia coli

Zeus Saldana-Ahuactzi et al.

Summary: This study investigated the role of virulence and global regulators in the regulation of the fimS switch in the human enteropathogenic E. coli (EPEC) strain E2348/69. The results demonstrated that Fis is a negative regulator of type 1 pili (T1P) expression and is likely required for the inversion of the fimS switch.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

The stationary phase-specific sRNA FimR2 is a multifunctional regulator of bacterial motility, biofilm formation and virulence

Nicole Raad et al.

Summary: Bacterial pathogens employ various virulence factors to invade hosts, and their use is tightly regulated to maximize infection efficiency. In this study, researchers discovered that a small non-coding RNA called FimR2 regulates the biosynthesis of fimbriae and flagella, leading to biofilm formation during stationary phase in Escherichia coli. FimR2 interacts with a translational regulator called CsrA, controlling motility and biofilm formation. This research highlights the importance of bacterial sRNAs in modulating bacterial physiology, including stationary phase and virulence.

NUCLEIC ACIDS RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Identification of allosteric hotspots regulating the ribosomal RNA binding by antibiotic resistance-conferring Erm methyltransferases

Ruchika Bhujbalrao et al.

Summary: Antibiotic resistance through epigenetic methylation of ribosomal RNA is a common strategy used by multidrug resistant pathogens. This study reveals the importance of a specific RNA structure in methylation at the pathogenic site. Fluorescent nucleotide-labeled RNA sequences show that base flipping is necessary for effective methylation, and distal bases assist in recognition and flipping. Molecular dynamic simulation studies demonstrate significant conformational changes in RNA during protein-rRNA handshake.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Review Immunology

Deciphering the genetic network and programmed regulation of antimicrobial resistance in bacterial pathogens

Thandavarayan Ramamurthy et al.

Summary: Antimicrobial resistance in bacteria is a crucial global health issue that affects humans, animals, and the environment. Understanding how bacteria resist and regulate antimicrobial genes is essential for controlling the development of resistance.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Infectious Diseases

Epigenetic-Mediated Antimicrobial Resistance: Host versus Pathogen Epigenetic Alterations

Jibran Sualeh Muhammad et al.

Summary: Since the discovery of antibiotics, humans have benefited from decreased morbidity and mortality associated with bacterial infections. However, the misuse of antibiotics has led to the emergence of multi-drug resistant bacterial infections, which is a major health concern. Bacteria exposed to inappropriate levels of antibiotics undergo genetic changes that enable them to survive in the host and become more resistant.

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Teg58, a small regulatory RNA, is involved in regulating arginine biosynthesis and biofilm formation in Staphylococcus aureus

Adhar C. Manna et al.

Summary: Staphylococcus aureus uses regulatory proteins and small regulatory RNAs to adapt and respond to different environmental cues. A study characterized teg58, a SarA repressed sRNA, and found that it plays an important role in modulating arginine biosynthesis and biofilm formation in S. aureus.

SCIENTIFIC REPORTS (2022)

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Arginine 58 is indispensable for proper function of the Francisella tularensis subsp. holarctica FSC200 HU protein, and its substitution alters virulence and mediates immunity against wild-type strain

Pavla Pavlik et al.

Summary: This study identified the binding sites and binding motifs of HU protein in Francisella tularensis FSC200, and demonstrated the importance of HU protein in the pathogenesis and immune protection of FSC200. These findings deepen our understanding of the role of HU protein in tularaemia pathogenesis and suggest its significance in vaccine development.

VIRULENCE (2022)

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Review Immunology

Bacterial nucleoid-associated protein HU as an extracellular player in host-pathogen interaction

Pavla Stojkova et al.

Summary: HU protein, a member of the nucleoid-associated protein family, plays a crucial role in regulating bacterial virulence, pathogenesis, and survival. Recent studies suggest that HU protein may not only exist inside bacteria but also be secreted outside bacteria and even enter host cells. However, its specific role in host cells is still not well understood and further research is needed.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Artemisinin derivative DHA27 enhances the antibacterial effect of aminoglycosides against Pseudomonas aeruginosa by inhibiting mRNA expression of aminoglycoside-modifying enzymes

Nuoyan Wang et al.

Summary: This study investigated the antibacterial sensitization effect of DHA27 combined with tobramycin in tobramycin-resistant Pseudomonas aeruginosa. The combination showed significant antibacterial effects on many resistant strains and reduced bacterial load in the spleen and lungs in a mouse model. The study also revealed that the effect was related to the inhibition of mRNA expression of aminoglycoside-modifying enzymes.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Microbiology

Systematic Identification of CpxRA-Regulated Genes and Their Roles in Escherichia coli Stress Response

Zhe Zhao et al.

Summary: The CpxRA system senses environmental stresses and regulates gene transcription for adaptation. This study identified over 10,000 putative CpxR binding sites and confirmed experimentally that 73 candidate genes are regulated by CpxR. These findings greatly expand our understanding of the CpxRA-dependent stress response network in Escherichia coli.

MSYSTEMS (2022)

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A Trade-Off for Maintenance of Multidrug-Resistant IncHI2 Plasmids in Salmonella enterica Serovar Typhimurium through Adaptive Evolution

Jin-Fei Zhang et al.

Summary: Understanding the fitness costs associated with plasmid carriage is crucial for understanding the mechanisms of plasmid maintenance in bacteria. This study investigated the compensatory mechanisms used by Salmonella enterica serovar Typhimurium to maintain a multidrug-resistant plasmid in the presence and absence of antibiotics. It was found that specific plasmid genes and the MDR regions played a role in the fitness costs, and plasmid deletions could compensate for these costs. The study also found that chromosomal gene mutations and altered mRNA expression correlated with changes in bacterial physiology. These findings contribute to our understanding of plasmid maintenance and antibiotic resistance evolution.

MSYSTEMS (2022)

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Review Biochemistry & Molecular Biology

Nucleoid-associated proteins shape chromatin structure and transcriptional regulation across the bacterial kingdom

Haley M. Amemiya et al.

Summary: This article discusses the relationship between bacterial DNA organization and gene regulation, explores the similarity between bacterial chromatin and eukaryotic genome organization, and examines the role of nucleoid-associated proteins (NAPs) in regulating bacterial chromosomes. Through studying the regulatory roles of NAPs in several well-studied bacteria, a working definition and screening procedure for NAPs are proposed.

TRANSCRIPTION-AUSTIN (2021)

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Article Environmental Sciences

DNA phosphorothioate modification facilitates the dissemination of mcr-1 and blaNDM-1 in drinking water supply systems

Hira Khan et al.

Summary: The study found that DNA phosphorothioate modification can protect bacteria from chloramine disinfection, thereby facilitating the dissemination of antibiotic resistance genes in drinking water supply systems. In addition, network analysis suggests that Bdellovibrio may be a potential host for MCR genes, NDM genes, and dndB.

ENVIRONMENTAL POLLUTION (2021)

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Article Immunology

Disruption of Fis reduces bacterial persister formation by regulating glutamate metabolism in Salmonella

Dongmei Yan et al.

Summary: Persisters contribute to antibiotic treatment recalcitrance, and the deletion of the Fis gene regulating glutamate metabolism has been found to significantly reduce persister formation in S. Typhi.

MICROBIAL PATHOGENESIS (2021)

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Article Microbiology

Histone-Like Nucleoid Structuring Protein Modulates the Fitness of tet(X4)-Bearing IncX1 Plasmids in Gram-Negative Bacteria

Wenhui Cai et al.

Summary: The IncX1-type plasmid is a common vector for spreading the tet(X4) gene, with H-NS protein encoded by the tet(X4)-bearing plasmids facilitating virulence and biofilm formation in host bacteria. The expression of the hns gene positively impacts the fitness of host bacteria, while negatively correlating with the expression of the tet(X4) gene, indicating a regulatory role in adaptability.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Microbiology

Characterization of the Type I Restriction Modification System Broadly Conserved among Group A Streptococci

Sruti DebRoy et al.

Summary: This study focused on the impact of the core chromosomal type I restriction modification (RM) system on DNA methylation in beta-hemolytic streptococci, revealing that its primary role is immunity against exogenous DNA rather than affecting the expression of the key multigene activator protein (Mga) or Mga-regulated genes.

MSPHERE (2021)

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Review Biochemistry & Molecular Biology

Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors

Irene Jurado-Martin et al.

Summary: Pseudomonas aeruginosa is a dominant pathogen in cystic fibrosis patients, with its adaptability and numerous virulence factors contributing to chronic infections. Understanding these virulence mechanisms is crucial for developing therapeutic strategies and vaccines against this multi-resistant pathogen.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Infectious Diseases

Overexpression of Efflux Pumps Mediate Pan Resistance of Klebsiella pneumoniae Sequence Type 11

Fei Lv et al.

Summary: KPN142, a clinically isolated pan-resistant strain of Klebsiella pneumoniae, showed limited antibiotic resistances mediated mainly by enzymes, with efflux pumps contributing most to pan resistance. Overexpression of the AcrAB-TolC efflux pump system played a key role in the resistance pattern of KPN142, while absence of suppressor gene mgrB and overexpression of phoPQ contributed to its resistance to colistin B.

MICROBIAL DRUG RESISTANCE (2021)

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Article Biochemistry & Molecular Biology

A ProQ/FinO family protein involved in plasmid copy number control favours fitness of bacteria carrying mcr-1-bearing IncI2 plasmids

Jun Yang et al.

Summary: The study reveals that the PcnR protein encoded by the IncI2 plasmid balances mcr-1 expression and bacterial fitness by repressing plasmid copy number, essential for the persistence of the mcr-1-bearing IncI2 plasmid in bacterial populations. Maintaining the mcr-1 plasmid at a single copy is crucial for its persistence and explains the reduced prevalence of mcr-1 following the ban of colistin as a growth promoter in China.

NUCLEIC ACIDS RESEARCH (2021)

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Article Microbiology

Streptococcus suis Encodes Multiple Allelic Variants of a Phase-Variable Type III DNA Methyltransferase, ModS, That Control Distinct Phasevarions

Greg Tram et al.

Summary: Streptococcus suis is a significant pathogen causing bacterial meningitis in humans and pigs. A Type III DNA methyltransferase called ModS in S. suis controls phasevarions through biphasic ON-OFF switching, influencing growth patterns and antibiotic resistance. Understanding ModS phase variation is crucial for developing treatments and vaccines against this important pathogen.

MSPHERE (2021)

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Antibiotic Toxicity Profiles of Escherichia coli Strains Lacking DNA Methyltransferases

Zheng Chen et al.

Summary: Researching the impact of DNA methyltransferase on antibiotic toxicity can help address antibiotic resistance issues. Our experiments showed that E. coli strains lacking DNA methyltransferase genes were more sensitive to antibiotics.

ACS OMEGA (2021)

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Review Biochemistry & Molecular Biology

The leucine-responsive regulatory proteins/feast-famine regulatory proteins: an ancient and complex class of transcriptional regulators in bacteria and archaea

Christine A. Ziegler et al.

Summary: FFRPs are widely distributed in bacteria and archaea, playing significant roles in gene regulation. They detect environmental nutritional status and regulate gene expression to implement appropriate behaviors for the specific ecological niche of each organism.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori

Sandy R. Pernitzsch et al.

Summary: RepG modulates the expression of TlpB chemotaxis receptor in Helicobacter pylori while also controlling lipopolysaccharide biosynthesis, antibiotic susceptibility, and in-vivo stomach colonization by regulating a gene co-transcribed with TlpB.

NATURE COMMUNICATIONS (2021)

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Histone-like nucleoid-structuring protein (H-NS) regulatory role in antibiotic resistance in Acinetobacter baumannii

Deja Rodgers et al.

Summary: In the study of Acinetobacter baumannii, a key transcriptional regulator H-NS was found to play an important role in antimicrobial resistance, biofilm production, and quorum sensing gene expression. Inactivation of H-NS led to increased resistance to colistin and altered stress response, while its absence resulted in upregulation of certain genes associated with antibiotic resistance. These findings demonstrate the complexity of the regulatory role of H-NS in combating A. baumannii infections.

SCIENTIFIC REPORTS (2021)

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Article Immunology

MgaSpn is a negative regulator of capsule and phosphorylcholine biosynthesis and influences the virulence of Streptococcus pneumoniae D39

Shengnan Xiao et al.

Summary: The global transcriptional regulator MgaSpn in Streptococcus pneumoniae regulates the biosynthesis of the capsule and phosphorylcholine, impacting the virulence of the pathogen. Mutants lacking MgaSpn exhibited altered capsule and phosphorylcholine production, leading to increased disease severity compared to the wild-type strain.

VIRULENCE (2021)

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Article Biochemistry & Molecular Biology

In vivo targets of Salmonella FinO include a FinP-like small RNA controlling copy number of a cohabitating plasmid

Youssef El Mouali et al.

Summary: FinO-domain proteins, as an emerging family of RNA-binding proteins, have diverse roles in bacterial post-transcriptional control and physiology, with the ability to act selectively or promiscuously on the same cellular RNA pool. The study extensively profiled cellular transcripts associated with the virulence plasmid-encoded FinO in Salmonella, identifying two major ligands: FinP and RepX. The research also observed cross-regulation of plasmids on the RNA level, with the FinO RBP controlling the replication of an antibiotic resistance plasmid in Salmonella.

NUCLEIC ACIDS RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

The Small RNAs PA2952.1 and PrrH as Regulators of Virulence, Motility, and Iron Metabolism in Pseudomonas aeruginosa

Shannon R. Coleman et al.

Summary: Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, can easily adapt to different conditions and stresses due to its genome encoding hundreds of potential intergenic small RNAs. Overexpression of certain sRNAs, such as PrrH and PA2952.1, in strain PAO1 resulted in changes in swimming and swarming motilities, cytotoxicity, and antibiotic resistance under swarming conditions. Transcriptome sequencing and proteomic analysis revealed substantial dysregulation of genes, proteins, and regulatory factors, indicating an important role for sRNA PA2952.1 in regulating virulence-related programs in P. aeruginosa.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2021)

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Review Microbiology

Antibiotic Resistance and Epigenetics: More to It than Meets the Eye

Dipannita Ghosh et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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The bacterial epigenome

Maria A. Sanchez-Romero et al.

NATURE REVIEWS MICROBIOLOGY (2020)

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Estrogen-induced epigenetic silencing ofFTH1andTFRCgenes reduces liver cancer cell growth and survival

Jibran Sualeh Muhammad et al.

EPIGENETICS (2020)

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ncRNAs: New Players in Mitochondrial Health and Disease?

Mirjana Gusic et al.

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A rare carbapenem-resistant hypervirulent K1/ST1265 Klebsiella pneumoniae with an untypeable blaKPC-harboured conjugative plasmid

Cuidan Li et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2020)

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Overexpression of the Small RNA PA0805.1 in Pseudomonas aeruginosa Modulates the Expression of a Large Set of Genes and Proteins, Resulting in Altered Motility, Cytotoxicity, and Tobramycin Resistance

Shannon R. Coleman et al.

MSYSTEMS (2020)

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Genetic identification of the functional surface for RNA binding by Escherichia coli ProQ

Smriti Pandey et al.

NUCLEIC ACIDS RESEARCH (2020)

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Epigenetic Regulation of Virulence and Immunoevasion by Phase-Variable Restriction-Modification Systems in Bacterial Pathogens

Kate L. Seib et al.

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Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Hailing Shi et al.

MOLECULAR CELL (2019)

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Role of AcrAB-TolC multidrug efflux pump in drug-resistance acquisition by plasmid transfer

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SCIENCE (2019)

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Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence

Pavla Stojkova et al.

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Phase-variable bacterial loci: how bacteria gamble to maximise fitness in changing environments

Zachary N. Phillips et al.

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A Small RNA Transforms the Multidrug Resistance of Pseudomonas aeruginosa to Drug Susceptibility

Carmen Oi Kwan Law et al.

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The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media

Luke V. Blakeway et al.

BMC MICROBIOLOGY (2019)

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Maintenance forced by a restriction-modification system can be modulated by a region in its modification enzyme not essential for methyltransferase activity

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MicC, a second small-RNA regulator of Omp protein expression in Escherichia coli

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Conjugal transfer of the virulence plasmid of Salmonella enterica is regulated by the leucine-responsive regulatory protein and DNA adenine methylation

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