期刊
LABORATORY ANIMALS
卷 50, 期 6, 页码 476-488出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0023677216670686
关键词
anaesthesia; analgesia; refinement; welfare; zebrafish
资金
- FCT [SFRH/BPD/103006/2014]
- European Investment Funds by FEDER/COMPETE/POCI [BI/CITAB/UTAD/VET/2015]
- FCT - Portuguese Foundation for Science and Technology [UID/AGR/04033/2013]
- Operacional Competitiveness and Internacionalization Programme [POCI-01-0145-FEDER-006958]
- Fundação para a Ciência e a Tecnologia [UID/AGR/04033/2013] Funding Source: FCT
Anaesthesia is used daily in fish experimental procedures; however, the use of an inadequate anaesthetic protocol can compromise not only the animal's welfare but also the reliability of results. The use of zebrafish (Danio rerio) in biomedical research has increased in the last decades, highlighting the importance of appropriate anaesthetic regimens for this species. This article reviews the main anaesthetic agents and protocols used in laboratory adult zebrafish, and some of the analgesic methods to be used in this species that still need more research. In addition, a systematized observation of signs is proposed to evaluate adult zebrafish welfare to reduce pain and distress.
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