4.7 Article

An in vivo humanized model to study homing and sequestration of Plasmodium falciparum transmission stages in the bone marrow

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Engineering, Biomedical

Organ-on-a-chip model of vascularized human bone marrow niches

Drew E. Glaser et al.

Summary: A 3D in vitro model of human bone marrow containing perivascular and endosteal niches has been developed using microfluidic and stem cell technologies. This model can replicate in vivo bone marrow function and study dynamic events at the niche level, providing opportunities to advance our understanding of human bone marrow function and drug response.

BIOMATERIALS (2022)

Review Immunology

Uncovering a Cryptic Site of Malaria Pathogenesis: Models to Study Interactions Between Plasmodium and the Bone Marrow

Tamar P. Feldman et al.

Summary: This review discusses the in vitro methods and potential applications for studying the host-parasite interactions in malaria infection in the bone marrow, as well as the importance of these studies for understanding the pathogenesis of malaria.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Review Immunology

Bone Marrow Niches and Tumour Cells: Lights and Shadows of a Mutual Relationship

Valentina Granata et al.

Summary: This article reviews the composition and functionality of the bone marrow niche in normal and malignant conditions, as well as the therapeutic implications of the interplay between its diverse cellular components and malignant cells.

FRONTIERS IN IMMUNOLOGY (2022)

Article Cell & Tissue Engineering

GsαR201C and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells

Biagio Palmisano et al.

Summary: The Gs alpha/cAMP signaling pathway plays a crucial role in regulating the homeostasis of the post-natal skeleton. Dysregulated activity of Gs alpha due to gain-of-function mutations can cause severe disruptions in bone architecture and function. This study provides evidence that the Adq-cell network not only regulates bone resorption but also contributes to bone formation, and that the Gs alpha/cAMP pathway is a key regulator of both functions.

BONE RESEARCH (2022)

Letter Hematology

Acute myeloid leukemia shapes the bone marrow stromal niche in vivo

Alice Pievani et al.

HAEMATOLOGICA (2021)

Review Cell Biology

The bone marrow hematopoietic niche and its adaptation to infection

Ana Cordeiro Gomes et al.

Summary: Hematopoiesis is a regulated process that relies on maintaining specific microenvironmental conditions within the bone marrow to support the formation of blood cells. Infections present a challenge to the hematopoietic niche, and the mechanisms by which they impact the bone marrow hematopoietic niche(s) are not fully understood.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

Review Immunology

Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem Cells

Lekhika Pathak et al.

Summary: The article examines the mechanisms of dormancy and reactivation of Mycobacterium tuberculosis in the stem cell microenvironment, suggesting that the interaction between the pathogen and the stem cell microenvironment may play a role in the development of post-primary tuberculosis. The potential impact of inflammation-induced reactivation of post-primary tuberculosis warrants further research attention, especially in a post COVID-19 pandemic world.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

From Stem Cells to Bone-Forming Cells

Samantha Donsante et al.

Summary: Bone formation begins in the embryonic stage and continues throughout life, involving stages of bone modeling and growth, remodeling, and regeneration. Osteoblasts produce, assemble, and control mineralization of the bone matrix, while regulating other cell processes and metabolic activities. Osteoblasts are derived from different skeletal stem cells under the control of multiple regulators at different developmental stages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria

Pedro Mejia et al.

Summary: Levels of the adipokine leptin are associated with neuropathology in experimental cerebral malaria (ECM), with infected red blood cells (iRBCs) sequestering in white adipose tissue (WAT) microvasculature leading to increased vascular permeability and local leptin production. In mice, parasite strains that do not sequester in WAT display reduced leptin production and protection from ECM. Adipocyte leptin production is regulated by the mechanistic target of rapamycin complex 1 (mTORC1) and disrupted by rapamycin, highlighting the potential implications of WAT sequestration for malaria infection pathogenesis, prognosis, and treatment.

SCIENCE ADVANCES (2021)

Review Pathology

New Insights into Malaria Pathogenesis

Christopher A. Moxon et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020 (2020)

Review Microbiology

Plasmodium asexual growth and sexual development in the haematopoietic niche of the host

Kannan Venugopal et al.

NATURE REVIEWS MICROBIOLOGY (2020)

Review Immunology

The Role of the Bone Marrow Microenvironment in the Response to Infection

Courtney B. Johnson et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow

Mariana De Niz et al.

SCIENCE ADVANCES (2018)

Article Biochemical Research Methods

Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue

Anjali P. Kusumbe et al.

NATURE PROTOCOLS (2015)

Article Biochemical Research Methods

An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development

Nicolas M. B. Brancucci et al.

NATURE PROTOCOLS (2015)

Article Cell Biology

Plasmodium falciparum transmission stages accumulate in the human bone marrow

Regina Joice et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Hematology

Osteoprogenitors and the hematopoietic microenvironment

Paolo Bianco et al.

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2011)

Article Multidisciplinary Sciences

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

Sophie H. Adjalley et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Origin of the human malaria parasite Plasmodium falciparum in gorillas

Weimin Liu et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

Benedetto Sacchetti et al.