4.8 Article

The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Toxicology

Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers

Amy L. Ball et al.

Summary: Mitochondrial DNA is highly polymorphic and can affect human population diversity and susceptibility to adverse drug reactions. Platelets offer a practical model for studying drug-induced mitochondrial dysfunction, with evidence showing that variation in mitochondrial genotype may impact sensitivity to mitochondrial toxicants.

ARCHIVES OF TOXICOLOGY (2021)

Article Toxicology

Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models

Samantha W. Jones et al.

Summary: Inhibition of DHODH has broad immunosuppressive effects and is a potential therapeutic target for malignancies, viral infections, and auto-immune diseases. FDA-approved DHODH inhibitors like leflunomide and teriflunomide have been linked to hepatotoxicity through mitochondrial dysfunction. The study suggests that some DHODH inhibitors may affect hepatic mitochondrial function through biotransformation.

TOXICOLOGY IN VITRO (2021)

Review Genetics & Heredity

The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review

Samantha W. Jones et al.

Summary: The triad of drug efficacy, toxicity and resistance is crucial in determining the risk-benefit balance of therapeutics. Pharmacogenomics can potentially improve this balance by stratifying patient populations based on DNA variants. Research on the impact of mitochondrial DNA variation on drug response is still inconclusive and further studies are needed to explain the variability in drug response.

FRONTIERS IN GENETICS (2021)

Review Biotechnology & Applied Microbiology

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Richard J. Weaver et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Review Biochemistry & Molecular Biology

Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity

Sophie L. Penman et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2020)

Review Gastroenterology & Hepatology

Acute liver failure induced by idiosyncratic reaction to drugs: Challenges in diagnosis and therapy

Shannan R. Tujios et al.

LIVER INTERNATIONAL (2018)

Review Pharmacology & Pharmacy

Challenges in designing and executing clinical trials in a dish studies

Bernard Fermini et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2018)

Review Cell Biology

Mitochondrial stress management: a dynamic journey

Miriam Valera-Alberni et al.

CELL STRESS (2018)

Article Biochemical Research Methods

Three-Dimensional Cell Cultures in Drug Discovery and Development

Ye Fang et al.

SLAS DISCOVERY (2017)

Article Biochemistry & Molecular Biology

Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming

S. Srinivasan et al.

ONCOGENE (2016)

Article Biochemistry & Molecular Biology

The contributions of respiration and glycolysis to extracellular acid production

Shona A. Mookerjee et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)

Review Medicine, Research & Experimental

In vitro platforms for evaluating liver toxicity

Shyam Sundhar Bale et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2014)

Article Gastroenterology & Hepatology

Pathogenesis of Idiosyncratic Drug-Induced Liver Injury and Clinical Perspectives

Robert J. Fontana

GASTROENTEROLOGY (2014)

Article Biochemical Research Methods

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

Joshua K. Salabei et al.

NATURE PROTOCOLS (2014)

Review Medicine, General & Internal

Drug-Induced Liver Injury

Michael D. Leise et al.

MAYO CLINIC PROCEEDINGS (2014)

Review Biochemistry & Molecular Biology

Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies

Heather M. Wilkins et al.

REDOX BIOLOGY (2014)

Review Medicine, General & Internal

Acute Liver Failure

William Bernal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Biochemistry & Molecular Biology

Mitochondrial DNA as a non-invasive biomarker: Accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias

Afshan N. Malik et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Genetics & Heredity

Updated Comprehensive Phylogenetic Tree of Global Human Mitochondrial DNA Variation

Mannis van Oven et al.

HUMAN MUTATION (2009)

Review Clinical Neurology

Tolcapone: An efficacy and safety review (2007)

C. Warren Olanow et al.

CLINICAL NEUROPHARMACOLOGY (2007)

Review Pharmacology & Pharmacy

The significance of mitochondrial toxicity testing in drug development

James A. Dykens et al.

DRUG DISCOVERY TODAY (2007)

Review Pharmacology & Pharmacy

Bicalutamide - Clinical pharmacokinetics and metabolism

ID Cockshott

CLINICAL PHARMACOKINETICS (2004)

Article Clinical Neurology

Tolcapone and hepatotoxic effects

CW Olanow

ARCHIVES OF NEUROLOGY (2000)