4.8 Article

The autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Autophagic degradation of membrane-bound organelles in plants

Jiaojiao Wang et al.

Summary: Eukaryotic cells have evolved membrane-bound organelles for specialized functions, and organelle quality control is crucial for normal cell homeostasis. Autophagy is a programmed process that clears unwanted or damaged organelles, enhancing cell adaptability.

BIOSCIENCE REPORTS (2023)

Article Cell Biology

Mechanistic insights into an atypical interaction between ATG8 and SH3P2 in Arabidopsis thaliana

Shuangli Sun et al.

Summary: The study uncovered an atypical interaction mode of Arabidopsis ATG8f with the plant unique adaptor protein SH3P2, showing unique conformational changes in ATG8f upon binding to the AIM sequence of the autophagic receptor NBR1. Additionally, the gel filtration assay revealed that the ubiquitin-associated domain of NBR1 outcompetes the SH3 domain of SH3P2 for ATG8f interaction. Biochemical and cellular analysis demonstrated distinct interfaces used by ATG8f to interact with NBR1 and SH3P2.

AUTOPHAGY (2022)

Article Biochemistry & Molecular Biology

A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component

Jia Xuan Leong et al.

Summary: Autophagy plays a crucial role in plant-bacteria interactions, where antimicrobial autophagy degrades intracellular pathogens and reveals a pathogen strategy of escaping elimination by hijacking the autophagy mechanism.

EMBO JOURNAL (2022)

Article Cell Biology

The CDC48 complex mediates ubiquitin-dependent degradation of intra-chloroplast proteins in plants

Jialong Li et al.

Summary: The CDC48 complex plays a crucial role in regulating ubiquitin-dependent degradation of intra-chloroplast proteins in response to oxidative stress in Arabidopsis thaliana. Defects in the CDC48 complex impair the ubiquitination and degradation of RbcL and AtpB proteins, leading to the accumulation of ubiquitinated chloroplast proteins. Functional analysis demonstrates that the CDC48 complex is required for plant tolerance to reactive oxygen species (ROS) stress.

CELL REPORTS (2022)

Article Multidisciplinary Sciences

Ubiquitin-based pathway acts inside chloroplasts to regulate photosynthesis

Yi Sun et al.

Summary: This study demonstrates the role of the nucleocytosolic ubiquitin-proteasome system (UPS) in regulating photosynthesis within endosymbiotically derived chloroplasts, through protein degradation.

SCIENCE ADVANCES (2022)

Article Plant Sciences

The CLP and PREP protease systems coordinate maturation and degradation of the chloroplast proteome in Arabidopsis thaliana

Elden Rowland et al.

Summary: This study uncovers strong genetic and functional interactions in Arabidopsis between the chloroplast stromal CLP chaperone-protease system and the PREP1,2 peptidases, shedding light on the protein quality control mechanisms in plant chloroplasts and mitochondria.

NEW PHYTOLOGIST (2022)

Review Cell Biology

NBR1: The archetypal selective autophagy receptor

Nikoline Lander Rasmussen et al.

Summary: NBR1 is an important autophagy receptor, serving as the main receptor in plants and co-existing with p62 in most animals. It participates in the selective autophagy of protein aggregates, and its mechanism and substrates are under investigation. Its roles in human diseases have also attracted attention.

JOURNAL OF CELL BIOLOGY (2022)

Article Cell Biology

Selective autophagy regulates heat stress memory inArabidopsisby NBR1-mediated targeting of HSP90 and ROF1

Venkatesh P. Thirumalaikumar et al.

Summary: Plants experience various stresses in their growth process, and autophagy plays an important role in regulating plant recovery and memory of heat stress. NBR1 functions as a receptor for selective autophagy during recovery from heat stress, interacting with HSP90.1 and ROF1 to mediate protein degradation and modulate the response to heat stress. Loss of NBR1 function results in a stronger memory phenotype for heat stress in plants.

AUTOPHAGY (2021)

Article Biochemical Research Methods

Cellpose: a generalist algorithm for cellular segmentation

Carsen Stringer et al.

Summary: Cellpose is a generalist, deep learning-based segmentation method that can precisely segment cells from various types of images without requiring retraining or parameter adjustments. It was trained on a highly diverse image dataset and supports a three-dimensional extension. Software has been developed to support community contributions to the training data.

NATURE METHODS (2021)

Review Biochemistry & Molecular Biology

Function of Chloroplasts in Plant Stress Responses

Yun Song et al.

Summary: Chloroplast plays a central role in photosynthesis and metabolism, and emerging as a crucial regulator in plant response to stress. Through gene expression and signal transduction, it interacts with the environment to help plants adapt to adverse conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Plant Sciences

The core autophagy machinery is not required for chloroplast singlet oxygen-mediated cell death in the Arabidopsis thaliana plastid ferrochelatase two mutant

Matthew D. Lemke et al.

Summary: Chloroplasts respond to stress by producing ROS, including singlet oxygen (O-1(2)), which triggers cellular degradation. This degradation process involves autophagy-related genes, but autophagosome formation is found to be dispensable for O-1(2)-induced cell death. Instead, an alternate form of autophagy, microautophagy, may play a role in degrading O-1(2)-damaged chloroplasts. Overall, chloroplast function and degradation involve complex interactions of multiple autophagy and degradation machineries, depending on the type of stress encountered.

BMC PLANT BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1

Ying-Ying Wang et al.

Summary: This study uncovers the mechanism of how a receptor called Nbr1 in fission yeast recognizes specific protein cargos, revealing the mechanism of autophagy cargo recognition. The research shows that Nbr1-ZZ1 can not only recognize the N-termini of cargos via a conserved acidic pocket, but also engage other parts of the cargos in a cargo-specific manner.

EMBO JOURNAL (2021)

Article Plant Sciences

Autophagy mutants show delayed chloroplast development during de-etiolation in carbon limiting conditions

Akila Wijerathna-Yapa et al.

Summary: Autophagy is crucial for plant growth and development under nutrient deprivation conditions. Mutants lacking functioning autophagy showed delayed chloroplast development after germinating in darkness, possibly due to insufficient lipid turnover and levels of carbon resources.

PLANT JOURNAL (2021)

Article Multidisciplinary Sciences

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

Eleonora Turco et al.

Summary: Misfolded proteins are ubiquitinated and condensed by cargo receptors for selective autophagy. The study elucidates the roles of p62/SQSTM1, NBR1, and TAX1BP1 in the formation and degradation of ubiquitin condensates through autophagy.

NATURE COMMUNICATIONS (2021)

Article Plant Sciences

Arabidopsis cargo receptor NBR1 mediates selective autophagy of defective proteins

Hyera Jung et al.

JOURNAL OF EXPERIMENTAL BOTANY (2020)

Article Multidisciplinary Sciences

Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

Arjen J. Jakobi et al.

NATURE COMMUNICATIONS (2020)

Article Plant Sciences

AtNBR1 Is a Selective Autophagic Receptor for AtExo70E2 in Arabidopsis

Changyang Ji et al.

PLANT PHYSIOLOGY (2020)

Article Multidisciplinary Sciences

Ubiquitin-dependent chloroplast-associated protein degradation in plants

Qihua Ling et al.

SCIENCE (2019)

Article Multidisciplinary Sciences

Quantifying the impact of public omics data

Yasset Perez-Riverol et al.

NATURE COMMUNICATIONS (2019)

Review Plant Sciences

Vacuolar degradation of chloroplast components: autophagy and beyond

Marisa S. Otegui

JOURNAL OF EXPERIMENTAL BOTANY (2018)

Review Plant Sciences

Reactive oxygen species, oxidative signaling and the regulation of photosynthesis

Christine H. Foyer

ENVIRONMENTAL AND EXPERIMENTAL BOTANY (2018)

Article Biochemistry & Molecular Biology

Bacteria Exploit Autophagy for Proteasome Degradation and Enhanced Virulence in Plants

Suayib Ustun et al.

PLANT CELL (2018)

Article Plant Sciences

Selective Elimination of Membrane-Damaged Chloroplasts via Microautophagy

Sakuya Nakamura et al.

PLANT PHYSIOLOGY (2018)

Article Multidisciplinary Sciences

Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter

Do Hoon Kwon et al.

NATURE COMMUNICATIONS (2018)

Review Biochemistry & Molecular Biology

Essentials of Proteolytic Machineries in Chloroplasts

Kenji Nishimura et al.

MOLECULAR PLANT (2017)

Article Biochemistry & Molecular Biology

Entire Photodamaged Chloroplasts Are Transported to the Central Vacuole by Autophagy

Masanori Izumi et al.

PLANT CELL (2017)

Article Multidisciplinary Sciences

Selective autophagy limits cauliflower mosaic virus infection by NBR1-mediated targeting of viral capsid protein and particles

Anders Hafren et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemical Research Methods

The Perseus computational platform for comprehensive analysis of (prote)omics data

Stefka Tyanova et al.

NATURE METHODS (2016)

Article Multidisciplinary Sciences

Ubiquitin facilitates a quality-control pathway that removes damaged chloroplasts

Jesse D. Woodson et al.

SCIENCE (2015)

Article Cell Biology

NBR1 acts as an autophagy receptor for peroxisomes

Elizabeth Deosaran et al.

JOURNAL OF CELL SCIENCE (2013)

Article Biochemistry & Molecular Biology

Autophagy Contributes to Leaf Starch Degradation

Yan Wang et al.

PLANT CELL (2013)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Biochemical Research Methods

Isolating intact chloroplasts from small Arabidopsis samples for proteomic studies

Jeannette Kley et al.

ANALYTICAL BIOCHEMISTRY (2010)

Article Cell Biology

Structural basis of target recognition by Atg8/LC3 during selective autophagy

Nobuo N. Noda et al.

GENES TO CELLS (2008)

Article Biochemistry & Molecular Biology

Structural basis for sorting mechanism of p62 in selective autophagy

Yoshinobu Ichimura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Cell Biology

Atg8 controls phagophore expansion during autophagosome formation

Zhiping Xie et al.

MOLECULAR BIOLOGY OF THE CELL (2008)

Article Biochemical Research Methods

Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis

Sang-Dong Yoo et al.

NATURE PROTOCOLS (2007)

Article Biochemical Research Methods

Absolute quantification of proteins by LCMSE - A virtue of parallel MS acquisition

JC Silva et al.

MOLECULAR & CELLULAR PROTEOMICS (2006)

Article Biochemistry & Molecular Biology

Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

ML Seibenhener et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Cell Biology

Molecular dissection of autophagy: Two ubiquitin-like systems

Y Ohsumi

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)