The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures

The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic modifications that may influence female reproduction and could affect IVF success.

Automated summary

The decline in fertility rates and increasing age of reproductive individuals are contributing factors to low clinical pregnancy rates in industrialized countries. Epigenetic modifications play a crucial role in embryonic development during in vitro fertilization (IVF) protocols in women. This article discusses the main epigenetic mechanisms that can impact female reproduction and potentially affect the success of IVF.