期刊
LAB ON A CHIP
卷 16, 期 20, 页码 3866-3884出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6lc00984k
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资金
- BioNano Health-Guard Research Center - Ministry of Science, ICT & Future Planning (MSIP) of Korea as Global Frontier Project, Republic of Korea [H-GUARD_2014M3A6B2060503]
- National Research Foundation (NRF) of Korea grant - MSIP [2016R1A6A1A03012845]
- NRF of Korea grant - MSIP [2015R1A2A1A15054236]
The invention of the polymerase chain reaction (PCR) has caused a revolution in molecular biology, giving access to a method of amplifying deoxyribonucleic acid (DNA) molecules across several orders of magnitude. Since the first application of PCR in a microfluidic device was developed in 1998, an increasing number of researchers have continued the development of microfluidic PCR systems. In this review, we introduce recent developments in microfluidic-based space and time domain devices as well as discuss various designs integrated with multiple functions for sample preparation and detection. The development of isothermal nucleic acid amplification and digital PCR microfluidic devices within the last five years is also highlighted. Furthermore, we introduce various commercial microfluidic PCR devices.
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