期刊
LAB ON A CHIP
卷 16, 期 3, 页码 525-531出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5lc01136a
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资金
- Chinese Recruitment Program of Global Experts
- Innovative and Entrepreneurial Talent Recruitment Program of Jiangsu Province
- National Natural Science Foundation of China [21405014, 91227124, 21327902]
- Natural Science Foundation of Jiangsu [BK20140619]
- Science and Technology Development Program of Suzhou [ZXY201439]
- Research Fund for the Doctoral Program of Higher Education of China [20120092130006]
We report an exothermic chip for quantitative point-of-care testing using a forehead thermometer as a readout. The chip has a capillary channel that directs an aqueous sample into an exothermic reservoir. NaOH powders are preloaded in the reservoir as the exothermic reagent. At the inlet of the capillary channel, a microvalve is fabricated using an aptamer-modified hydrogel which is responsive to a specific analyte. When the aqueous sample comes in contact with the hydrogel valve, the hydrogel shrinks due to the selective analyte-hydrogel interaction. The volume reduction of the hydrogel increases the capillary flow rate, and thus increases the heat produced by NaOH dissolution. A forehead thermometer is used to measure the temperature increment which is correlated with the analyte concentration. Using this method, heavy metal ions (Hg2+ and Pb2+) in different real samples are quantitatively analyzed.
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