期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202300198
关键词
Acid-base catalysis; Boron; Frustrated Lewis pair; Lewis acids; Cooperative catalysis
We propose a method for the combination of N-allylamines and carbonyl compounds through the concerted action of B(C6F5)(3) and a N-based Bronsted base under redox-neutral conditions. By the reaction of in situ generated conjugated iminium ions and enolates, & delta;-aminocarbonyl compounds are obtained without waste generation. Furthermore, the cooperative action of B(C6F5)(3), a chiral Zn-based complex, and an amine enables the stereoselective reaction of a glycinate Schiff base ester and an N-allylamine to yield an & alpha;-substituted & alpha;-amino ester.
We present a strategy for the union of N-allylamines and carbonyl compounds by the concerted action of B(C6F5)(3) and a N-based Bronsted base under redox-neutral conditions. The reaction of in situ generated conjugated iminium ions and enolates affords & delta;-aminocarbonyl compounds without waste generation. Furthermore, we describe that the cooperative action of B(C6F5)(3), a chiral Zn-based complex, and an amine facilitates the stereoselective reaction of a glycinate Schiff base ester and an N-allylamine to afford an & alpha;-substituted & alpha;-amino ester.
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