期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202300269
关键词
Alkene synthesis; Cobalt; C-S activation; 1; 3-Dithiolane; Grignard reagent
This article describes the cobalt-catalyzed reaction between 1,3-dithiolanes and Grignard reagents for the efficient synthesis of multi-substituted alkene products. The method is applicable to various benzylic dithiolane substrates, providing good to excellent yields of di-, tri-, and tetra-substituted 1,1-diaryl alkene products. By using benzylic Grignard reagents and aryl aldehyde-derived 1,3-dithiolanes, natural product-derived stilbene architectures with exquisite E selectivity can be accessed. The simplicity, low catalyst loadings, and scalability of the method demonstrate its general utility.
The cobalt-catalyzed reaction between 1,3-dithiolanes and Grignard reagents, for the efficient synthesis of multi-substituted alkene products, is described. The method was applicable to a variety of benzylic dithiolane substrates, affording di-, tri-, and tetra-substituted 1,1-diaryl alkene products in good to excellent yields. The use of benzylic Grignard reagents with aryl aldehyde-derived 1,3-dithiolanes enabled access to natural product-derived stilbene architectures with exquisite E selectivity. The operational simplicity, low catalyst loadings, and scalability demonstrate the general utility of the method.
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