Synthesis of Hybrid Isoxazole-triazole Compounds as Potential Antiproliferative Agents

An efficient route for the synthesis of a series of new hybrid isoxazole-triazole compounds in high yields and excellent regioselectivity starting from either 2-aryl-1,1-dichlorocyclopropanes or N-hydroxybenzimidoyl chlorides was developed. The synthesized isoxazole-triazole hybrids were evaluated for their biological activity.

Automated summary

An efficient synthesis route for new hybrid isoxazole-triazole compounds was developed starting from 2-aryl-1,1-dichlorocyclopropanes or N-hydroxybenzimidoyl chlorides, achieving high yields and excellent regioselectivity. The synthesized compounds were evaluated for their biological activity.