4.5 Article

Synthesis of Dihydropyrazoles by Pd-Catalyzed Carboamination of Alkenyl Hydrazones with Aryl Triflates

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Organic

Synthesis of dihydropyrazoles enabled by Pd-catalyzed carboamination of alkenyl hydrazones with alkenyl and aryl halides

Yinqiang Wang et al.

Summary: A novel and highly efficient strategy for the synthesis of dihydropyrazoles via Pd-catalyzed carboamination reaction has been demonstrated. This methodology provides a practical protocol for accessing various substituted dihydropyrazoles with good yields and good functional group tolerance.

ORGANIC CHEMISTRY FRONTIERS (2022)

Article Chemistry, Organic

Efficient enantioselective synthesis of pyrazolines and isoxazolines enabled by an iridium-catalyzed intramolecular allylic substitution reaction

Fang Hu et al.

Summary: An efficient Ir-catalyzed enantioselective intramolecular allylic substitution reaction has been developed for the synthesis of five-, six- and seven-membered heterocycles containing N-N and N-O bonds.

ORGANIC CHEMISTRY FRONTIERS (2022)

Review Chemistry, Applied

Radical Cascade Reactions of β,γ-Unsaturated Hydrazones/Oximes

Ya-Feng Si et al.

Summary: This review summarizes and classifies three catalytic ways of radical cascade cyclization of beta,gamma-unsaturated hydrazones/oximes: transition-metal-catalyzed systems, transition-metal-free systems, and photo-/electrocatalytic systems. Through these methods, various functional groups are installed on the pyrazoline and isoxazoline skeletons to enrich the small organic molecule library.

ADVANCED SYNTHESIS & CATALYSIS (2021)

Article Chemistry, Multidisciplinary

Asymmetric catalytic 1,3-dipolar cycloaddition of α-diazoesters for synthesis of 1-pyrazoline-based spirochromanones and beyond

Peng Zhao et al.

Summary: In this study, a highly enantioselective 1,3-dipolar cycloaddition of alpha-substituted diazoesters with exocyclic enones was achieved using a chiral scandium(III)/N,N'-dioxide complex as the catalyst. The protocol provided an efficient route to optically active products with good outcomes, including up to 97% yield and 98% ee with >95:5 dr. Additionally, enantioenriched 2-pyrazoline-based spirochromanones were accessible by switching alpha-substituted diazoesters to alpha-diazoacetates. Further specific transformations of chiral pyrazoline-based spiro-compounds to spirocyclopropane derivatives were also disclosed in the study.

SCIENCE CHINA-CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Mn- and Co-Catalyzed Aminocyclizations of Unsaturated Hydrazones Providing a Broad Range of Functionalized Pyrazolines

Moritz Balkenhohl et al.

Summary: Manganese- and cobalt-catalyzed aminocyclization reactions of unsaturated hydrazones have been reported, allowing for selective formation of different products. Various functional groups were introduced, and a progesterone receptor antagonist was successfully prepared using the amino-cyclization protocol.

JACS AU (2021)

Article Chemistry, Organic

One-Pot and Two-Pot Synthesis of Chalcone Based Mono and Bis-Pyrazolines

Saba Farooq et al.

TETRAHEDRON LETTERS (2020)

Article Chemistry, Applied

Synthesis of Tetrahydropyridazines via Pd-Catalyzed Carboamination of Alkenyl Hydrazones

Yajing Guo et al.

ADVANCED SYNTHESIS & CATALYSIS (2020)

Article Chemistry, Multidisciplinary

Enantioselective Synthesis of Isoxazolines Enabled by Palladium-Catalyzed Carboetherification of Alkenyl Oximes

Lei Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Chemistry, Multidisciplinary

When Light Meets Nitrogen-Centered Radicals: From Reagents to Catalysts

Xiao-Ye Yu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

Review Biochemistry & Molecular Biology

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

Dimitris Matiadis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Chemistry, Multidisciplinary

One-Pot Catalytic Enantioselective Synthesis of 2-Pyrazolines

Connor J. Thomson et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Chemistry, Organic

Synthesis of acyloxyl pyrazolines by copper-mediated aminoacyloxylation of unsaturated ketohydrazones

Manman Chen et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2018)

Article Chemistry, Organic

Copper-Catalyzed Diamination of Alkenes of Unsaturated Ketohydrazones with Amines

Manman Chen et al.

ORGANIC LETTERS (2018)

Review Chemistry, Organic

Recent Developments in Pd0-Catalyzed Alkene-Carboheterofunctionalization Reactions

Zachary J. Garlets et al.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2017)

Review Chemistry, Multidisciplinary

Exploration of Visible-Light Photocatalysis in Heterocycle Synthesis and Functionalization: Reaction Design and Beyond

Jia-Rong Chen et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

Article Chemistry, Multidisciplinary

One-Pot Three-Component Synthesis of Vicinal Diamines via In Situ Aminal Formation and Carboamination

Ugo Orcel et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Chemistry, Multidisciplinary

Synthesis of Chiral 1,4-Benzodioxanes and Chromans by Enantioselective Palladium-Catalyzed Alkene Aryloxyarylation Reactions

Naifu Hu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Chemistry, Multidisciplinary

Asymmetric Palladium-Catalyzed Alkene Carboamination Reactions for the Synthesis of Cyclic Sulfamides

Zachary J. Garlets et al.

CHEMISTRY-A EUROPEAN JOURNAL (2016)

Article Chemistry, Multidisciplinary

Organophotocatalytic Generation of N- and O-Centred Radicals Enables Aerobic Oxyamination and Dioxygenation of Alkenes

Xiao-Qiang Hu et al.

CHEMISTRY-A EUROPEAN JOURNAL (2016)

Review Chemistry, Medicinal

Pharmacological Activity of 4,5-Dihydropyrazole Derivatives (Review)

D. D. Korablina et al.

PHARMACEUTICAL CHEMISTRY JOURNAL (2016)

Article Chemistry, Multidisciplinary

Transition from p Radicals to s Radicals: Substituent-Tuned Cyclization of Hydrazonyl Radicals

Xiao-Yong Duan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Chemistry, Multidisciplinary

Photocatalytic Generation of N-Centered Hydrazonyl Radicals: A Strategy for Hydroamination of β,γ-Unsaturated Hydrazones

Xiao-Qiang Hu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Review Biochemistry & Molecular Biology

4,5-Dihydro-1H-pyrazole: an indispensable scaffold

Jimi Marin Alex et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2014)

Article Chemistry, Organic

Catalytic Enantioselective Iodoaminocyclization of Hydrazones

Chandra Bhushan Tripathi et al.

ORGANIC LETTERS (2014)

Review Plant Sciences

Natural Products Containing a Nitrogen-Nitrogen Bond

Lachlan M. Blair et al.

JOURNAL OF NATURAL PRODUCTS (2013)

Review Chemistry, Medicinal

Pyrazolines: A Biological Review

Akranth Marella et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2013)

Article Chemistry, Multidisciplinary

Synthesis of Enantiomerically Enriched Imidazolidin-2-Ones through Asymmetric Palladium-Catalyzed Alkene Carboamination Reactions

Brett A. Hopkins et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Article Chemistry, Multidisciplinary

Enantioselective Synthesis of Dihydropyrazoles by Formal [4+1] Cycloaddition of in Situ-Derived Azoalkenes and Sulfur Ylides

Jia-Rong Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Review Chemistry, Medicinal

Synthesis and Biological Activity of Chiral Dihydropyrazole: Potential Lead for Drug Design

X. -H. Liu et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2011)

Article Chemistry, Multidisciplinary

Enantioselective Phase-Transfer Catalysis: Synthesis of Pyrazolines

Olivier Mahe et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

Article Chemistry, Medicinal

Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors

Rossella Fioravanti et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Chemistry, Multidisciplinary

A Catalytic Asymmetric 6 pi Electrocyclization: Enantioselective Synthesis of 2-Pyrazolines

Steffen Mueller et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Article Chemistry, Organic

Mechanistic approaches to palladium-catalyzed alkene difunctionalization reactions

Katrina H. Jensen et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2008)

Review Chemistry, Multidisciplinary

Intramolecular aminopalladation of alkenes as a key step to pyrrolidines and related heterocycles

Ana Minatti et al.

CHEMICAL SOCIETY REVIEWS (2007)

Article Chemistry, Multidisciplinary

An entry to a chiral dihydropyrazole scaffold: Enantioselective [3+2] cycloaddition of nitrile imines

MP Sibi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)