期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 51, 期 1, 页码 131-138出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2022.2149542
关键词
alpha-Lipoic acid; hollow gold nanoparticles; antioxidant; ROS; osteoporosis
Osteoporosis, a common disease in the ageing society, is caused by oxidative stress due to excessive accumulation of reactive oxygen species (ROS). Alpha-lipoic acid (ALA) is an antioxidant that can eliminate excess ROS and inhibit oxidative stress. In this study, PEGylated hollow gold nanoparticles (HGNPs) loaded with ALA were designed to treat osteoporosis. The results showed that mPEG@HGNPs-ALA had good biocompatibility and the ability to reduce oxidative stress.
Osteoporosis is a common disease among the ageing society. Oxidative stress caused by excessive accumulation of reactive oxygen species (ROS) is the aetiology of osteoporosis. alpha-Lipoic acid (ALA) is an antioxidant in the body, which can eliminate excess ROS in the body and inhibits levels of oxidative stress in cells. Herein, we designed PEGylated hollow gold nanoparticles (HGNPs) loaded with ALA (mPEG@HGNPs-ALA) to remove ROS in the treatment of osteoporosis. First, mPEG@HGNPs with a particle size of & SIM;63 nm has been successfully synthesized. By comparing the drug loading of mPEG@HGNPs, it was concluded that the optimal mass ratio of mPEG@HGNPs (calculated by the amount of gold) to ALA was & SIM;1:2. ABTS antioxidant assay showed that free radical removal ability. In vitro results revealed that the preparation had good biocompatibility. At the gold concentration of 1-150 mu g/mL, the cell viability of mPEG@HGNPs was more than 100%, which indicated that it could promote the proliferation of osteoblasts. What's more, mPEG@HGNPs-ALA could effectively remove the ROS caused by H2O2 injury and improve the cell viability. According to these results, it can be considered that mPEG@HGNPs-ALA has the potential to treat osteoporosis.
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