Causal association of cardiovascular disease with erectile dysfunction: a two-sample bidirectional Mendelian randomization analysis

Article Andrology

Genetically predicted insomnia causally increases the risk of erectile dysfunction

Yang Xiong et al.

Summary: This study provides causal evidence that genetically predicted insomnia increases the risk of erectile dysfunction (ED), while sleep duration and chronotype do not.

ASIAN JOURNAL OF ANDROLOGY (2023)

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Article Andrology

Type 2 diabetes mellitus increases risk of erectile dysfunction independent of obesity and dyslipidemia: A Mendelian randomization study

Chi Yuan et al.

Summary: The study found a direct causal effect between type 2 diabetes mellitus and erectile dysfunction, independent of obesity and dyslipidemia. However, there was limited evidence to confirm the causal effect of body mass index on erectile dysfunction. Systolic blood pressure and lipid components did not show a significant causal effect on erectile dysfunction.

ANDROLOGY (2022)

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Article Endocrinology & Metabolism

Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction

Yang Xiong et al.

Summary: This study provides genetic evidence supporting the causal role of snoring in erectile dysfunction (ED).

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Andrology

Genetic susceptibility to COVID-19 may increase the risk of erectile dysfunction: A two-sample Mendelian randomization study

Kun Zhang et al.

Summary: This study using Mendelian randomization (MR) analysis found a causal relationship between genetic susceptibility to COVID-19 and an increased risk of erectile dysfunction (ED). This suggests that preventing COVID-19 could help reduce the risk of ED in the European population.

ANDROLOGIA (2022)

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Article Chemistry, Medicinal

Mechanism of Huoxue Tongluo Decoction in treatment of erectile dysfunction caused by ischemic stroke based on network pharmacology

Ji-sheng Wang et al.

Summary: The study investigated the therapeutic effect of Huoxue Tongluo Decoction on erectile dysfunction caused by ischemic stroke through network pharmacology and experimental studies. The results showed that the decoction improved erectile function by regulating the expression levels of TNF, eNOS, and VEGF, as well as enhancing the structural integrity of the cavernous tissue.

CHINESE HERBAL MEDICINES (2021)

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Article Psychiatry

Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders A Multivariable Mendelian Randomization Analysis

Daniel B. Rosoff et al.

Summary: The mendelian randomization analysis suggests potential causal associations between genetic liability for increased prescription opioid use and the risk for major depressive disorder and anxiety and stress-related disorders. Further replication studies are needed to guide prevention and intervention strategies for the opioid epidemic and depression.

JAMA PSYCHIATRY (2021)

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Article Medicine, General & Internal

Kidney damage causally affects the brain cortical structure: A Mendelian randomization study

Xiong Chen et al.

Summary: The study utilized Mendelian randomization to demonstrate a causal relationship between kidney damage and brain cortical structure, indicating the presence of a kidney-brain axis.

EBIOMEDICINE (2021)

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Review Clinical Neurology

Significant Increase of Erectile Dysfunction in Men With Post-stroke: A Comprehensive Review

Shankun Zhao et al.

Summary: This study found that stroke patients have a significantly higher risk of erectile dysfunction (ED) compared to the general population, and rehabilitative interventions are recommended to improve erectile function for stroke survivors with ED. The prevalence of ED in stroke patients was significantly higher than that of the general population.

FRONTIERS IN NEUROLOGY (2021)

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Article Medicine, General & Internal

The Prevalence of Erectile Dysfunction and Its Association with Cardiovascular Risk Factors in Patients after Myocardial Infarction

Egidija Rinkuniene et al.

Summary: This study found a high prevalence of erectile dysfunction (62%) in patients after a myocardial infarction, with severity increasing with age. Arterial hypertension was the most common cardiovascular risk factor associated with erectile dysfunction in these patients.

MEDICINA-LITHUANIA (2021)

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Article Medicine, Research & Experimental