Controlled Chitosan Molecular Weight Reduction by Mechanochemical and Aging-Based Phosphoric Acid Hydrolysis

Chitosan is typically produced by the deacetylation of the chitin biopolymer. Its molecular weight (Mw) is a function of the chitin source and the deacetylation conditions. It remains a challenge to both control the Mw of chitosan and obtain good monodispersity, which are essential for optimal function of chitosan in different applications. This study explores the use of mechanochemistry and aging as effective methods toward the controlled reduction of the Mw of commercial high Mw chitosan (HMwChs) with phosphoric acid, where Mw was measured by gel permeation chromatography (GPC). In comparison to conventional solution-based methods, this new mechanochemical method features improved process mass intensity in comparison to conventional techniques and affords low Mw chitosan (LMwChs) samples in a range of 200 to 19.5 kDa, with a polydispersity down to1.8.

Automated summary

This study explores the use of mechanochemistry and aging as effective methods to control the molecular weight of commercial high molecular weight chitosan. Compared to conventional solution-based methods, this new mechanochemical method has improved process mass intensity and produces low molecular weight chitosan samples with a range of 200 to 19.5 kDa and a polydispersity of 1.8.